Preliminary Evidence for Hepatitis Delta Virus Exposure in Patients Who Are Apparently Not Infected With Hepatitis B Virus

Chemin, Isabelle; Pujol, Flor H.; Scholtès, Caroline; Loureiro, Carmen L.; Amirache, Fouzia; Levrero, Massimo; Zoulim, Fabien; Pérez‐Vargas, Jimena; Cosset, François‐Loïc

doi:10.1002/hep.31453

Cited by 31 publications

(36 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, there was not a single patient in whom HDV antibodies were detected and in whom anti‐HBc was negative (n = 225; Fisher's exact test P < .0001, see Figure 1). Interestingly, at the time of revising this manuscript a new study did show for the first time HDV/HCV coinfection in 2/160 HCV‐RNA–positive patients from Venezuela 8 . To summarize our findings, we cannot exclude that patients had transient production with recombinant HCV/HDV particles, but while we are awaiting additional studies in endemic regions for HCV and HDV like Turkey or Mongolia, we conclude that the risk of HDV infection in HCV mono‐infected patients in Germany is distinctly remote.…”

Section: Resultsmentioning

confidence: 96%

Hepatitis delta virus propagation enabled by hepatitis C virus—Scientifically intriguing, but is it relevant to clinical practice?

Pflüger

Wiesch

Polywka

et al. 2020

Journal of Viral Hepatitis

View full text Add to dashboard Cite

In vitro cell culture experiments and animal models have demonstrated that hepatitis delta virus (HDV) can theoretically propagate being enveloped by human pathogenic viruses other than hepatitis B virus (HBV), namely hepatitis C virus (HCV) and dengue virus. However, the clinical relevance of these findings and whether HDV replication occurs in real‐world hepatitis B surface antigen (HBsAg)–negative HCV patient cohorts remain unknown. To this aim, we analysed 323 HCV‐RNA–positive and HBsAg‐negative sera for the presence of HDV‐RNA and anti‐HDV antibodies (anti‐HDV). All 323 (100%) samples were negative for HDV‐RNA. Interestingly, 8/316 samples tested positive for anti‐HDV. The HBV serology of these eight patients showed a positive result for HBV core antibodies (anti‐HBc) indicating a seroconversion of an acute HBV infection in the past. None of the anti‐HBc–negative patients were positive for anti‐HDV. Our results indicate a distinctly low probability of replicative HDV infection in HCV mono‐infected patients in Germany. Current German clinical guidelines rightly recommend performing HDV screening only in HBsAg‐positive patients. However, larger studies on this subject should be performed in regions that are endemic for chronic HBV/HDV as well as HCV infections.

show abstract

Section: Resultsmentioning

confidence: 96%

Hepatitis delta virus propagation enabled by hepatitis C virus—Scientifically intriguing, but is it relevant to clinical practice?

Pflüger

Wiesch

Polywka

et al. 2020

Journal of Viral Hepatitis

View full text Add to dashboard Cite

show abstract

“…Another study showed that HDV RNP could be packaged into the envelope proteins of vesiculo-, flavi-, and hepaciviruses in vitro, allowing the egress of HDV RNPs from cells and subsequent entry into cell lines expressing the respective receptors [ 87 ]. It is controversial whether HDV is able to use the envelopes of non-hepadnaviruses for dissemination in patients [ 88 , 89 , 90 ]. HBV envelope-independent spread may play a yet-unknown role in HDV persistence in CHD patients and challenge the effect of drugs interfering with HD virion production or de novo virus entry.…”

Section: Hdv Structure Replication and Persistencementioning

confidence: 99%

Interplay between Hepatitis D Virus and the Interferon Response

Zhang

Urban

2020

Viruses

View full text Add to dashboard Cite

Chronic hepatitis D (CHD) is the most severe form of viral hepatitis, with rapid progression of liver-related diseases and high rates of development of hepatocellular carcinoma. The causative agent, hepatitis D virus (HDV), contains a small (approximately 1.7 kb) highly self-pairing single-strand circular RNA genome that assembles with the HDV antigen to form a ribonucleoprotein (RNP) complex. HDV depends on hepatitis B virus (HBV) envelope proteins for envelopment and de novo hepatocyte entry; however, its intracellular RNA replication is autonomous. In addition, HDV can amplify HBV independently through cell division. Cellular innate immune responses, mainly interferon (IFN) response, are crucial for controlling invading viruses, while viruses counteract these responses to favor their propagation. In contrast to HBV, HDV activates profound IFN response through the melanoma differentiation antigen 5 (MDA5) pathway. This cellular response efficiently suppresses cell-division-mediated HDV spread and, to some extent, early stages of HDV de novo infection, but only marginally impairs RNA replication in resting hepatocytes. In this review, we summarize the current knowledge on HDV structure, replication, and persistence and subsequently focus on the interplay between HDV and IFN response, including IFN activation, sensing, antiviral effects, and viral countermeasures. Finally, we discuss crosstalk with HBV.

show abstract

“…was found positive in of 160 HCV patients without detectable HBV markers. 73 However, two other studies didn't find any HBV-independent HCV/HDV co-infection in more than 2000 HCV individuals. 74,75 Larger studies on this subject are needed in regions with high prevalence of chronic HBV/HDV and HCV and regions where parental infection routes have been studied and are known.…”

Section: Hdv Induced Liver Damagementioning

confidence: 97%

New insights into HDV persistence: The role of interferon response and implications for upcoming novel therapies

Zhang

Urban

2021

Journal of Hepatology

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Preliminary Evidence for Hepatitis Delta Virus Exposure in Patients Who Are Apparently Not Infected With Hepatitis B Virus

Cited by 31 publications

References 5 publications

Hepatitis delta virus propagation enabled by hepatitis C virus—Scientifically intriguing, but is it relevant to clinical practice?

Hepatitis delta virus propagation enabled by hepatitis C virus—Scientifically intriguing, but is it relevant to clinical practice?

Interplay between Hepatitis D Virus and the Interferon Response

New insights into HDV persistence: The role of interferon response and implications for upcoming novel therapies

Contact Info

Product

Resources

About