Preliminary Evidence of the Short Allele of the Serotonin Transporter Gene Predicting Poor Response to Cognitive Behavior Therapy in Posttraumatic Stress Disorder

Bryant, Richard A.; Felmingham, Kim L.; Falconer, Erin; Benito, Laarnie Pe; Dobson‐Stone, Carol; Pierce, Kerrie D.; Schofield, Peter R.

doi:10.1016/j.biopsych.2010.03.016

Cited by 103 publications

(89 citation statements)

References 19 publications

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“…As we hypothesized, the beneficial adaptive responses to positive stimuli may be used to offset the maladaptive responses to negative stimuli. 3 Bryant and colleagues 6 recently showed that 5-HTTLPR s-allele carriers with PTSD displayed more severe PTSD 6 months after exposure therapy than other patients. Based on the biological susceptibility model, we predict that s-allele carriers with PTSD will benefit from a "distraction" therapy, in which the presentation of positive stimuli draws attention away from fear-eliciting stimuli.…”

Section: Introductionmentioning

confidence: 99%

Behavioural therapy based on distraction alleviates impaired fear extinction in male serotonin transporter knockout rats

Nonkes

Pooter

Homberg

2012

jpn

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Section: Introductionmentioning

confidence: 99%

Behavioural therapy based on distraction alleviates impaired fear extinction in male serotonin transporter knockout rats

Nonkes

Pooter

Homberg

2012

jpn

View full text Add to dashboard Cite

“…Seven publications on 5 studies assessed if pretreatment biological and genetic variables could predict treatment outcome (table 3) [38,39,40,41,42,43,44]. One reported that genotyping was used [39], 3 reported neuroimaging [40,41,42], 1 reported endocrine measures [38] and 2 reported the use of psychophysiological measures [43,44].…”

Section: Resultsmentioning

confidence: 99%

“…One reported that genotyping was used [39], 3 reported neuroimaging [40,41,42], 1 reported endocrine measures [38] and 2 reported the use of psychophysiological measures [43,44]. …”

Section: Resultsmentioning

confidence: 99%

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Using Neurobiological Measures to Predict and Assess Treatment Outcome of Psychotherapy in Posttraumatic Stress Disorder: Systematic Review

Zantvoord¹,

Diehle²,

Lindauer³

2013

Psychother Psychosom

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Background: Trauma-focused cognitive-behavioral therapy (TF-CBT) and eye movement desensitization and reprocessing (EMDR) are effective treatments for posttraumatic stress disorder. However, little is known about their neurobiological effects. The usefulness of neurobiological measures to predict the treatment outcome of psychotherapy also has yet to be determined. Methods: Systematic review of randomized controlled trials (RCTs) focused on neurobiological treatment effects of TF-CBT or EMDR and trials with neurobiological measures as predictors of treatment response. Results: We included 23 publications reporting on 16 separate trials. TF-CBT was compared with a waitlist in most trials. TF-CBT was associated with a decrease in heart rate and blood pressure and changes in activity but not in volume of frontal brain structures and the amygdala. Neurobiological changes correlated with changes in symptom severity. EMDR was only tested against other active treatments in included trials. We did not find a difference in neurobiological treatment effects between EMDR and other treatments. Publications on neurobiological predictors of treatment response showed ambiguous results. Conclusion: TF-CBT was associated with a reduction of physiological reactivity. There is some preliminary evidence that TF-CBT influences brain regions involved in fear conditioning, extinction learning and possibly working memory and attention regulation; however, these effects could be nonspecific psychotherapeutic effects. Future trials should use paradigms aimed specifically at these brain regions and physiological reactivity. There are concerns regarding the risk of bias in some of the RCTs, indicating that methodologically more rigorous trials are required. Trials with neurobiological measures as predictors of treatment outcome render insufficient results to be useful in clinical practice.

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“…Furthermore, according to Bryant et al (2010), the lack of response to CBT intervention is strongly influenced by the feelings of fear or anxiety that existed before the intervention, because the fear affects the amygdala work becomes excessive so that a person with severe anxiety will have difficulty managing his anxiety.…”

Section: Discussionmentioning

confidence: 99%

Comparative Effectiveness of Cognitive Behavioral Therapy 5 Sessions and 12 Sessions Toward to Post Traumatic Stress Disorder on Post Flood Disaster Adolescent

Hayati

Sari²,

Mardhiyah³

2018

J Kep Padjadjaran

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Flood disaster conduced 2375 refugees and traumatic in adolescent with symptoms of Post Traumatic Stress Disorder as many as 15 people in Garut regency. The impact of PTSD on adolescents reduced brain volume, behavioral changed and short-term memory lost. The psychotherapy that proved to be effective overcome PTSD was Cognitive Behavioral Therapy (CBT) 12 sessions but the empirical evidence in Indonesia, the 12 session of CBT intervention was too long, tedious, and caused doubts to the therapist so that 5 session CBT intervention was considered more flexible and efficient. The purpose of this study was compare the effectiveness of PTSD scores pre and post intervention of CBT 5 sessions and 12 sessions toward of PTSD on post flood disaster in adolescent. This research used Quasi Experiment Design with Pre test and Post test approach Two Group Design. The first group was given CBT 5 sessions and the second group was given CBT 12 sessions with the total number of adolescent respondents were 38 people (aged 12-18). The sample was chosen by used Consecutive Sampling at two evacuation sites in Cilawu and Tarogong Kidul subdistrict, Garut regency, West Java, Indonesia. The results of this study pre and post intervention in both groups decreased of PTSD score which difference of median value of 6.00 on CBT 5 session and average difference of 7.58 on CBT 12 session with significancy (p-value < 0.01) and the result analysis test on the effectiveness of both interventions (p-value > 0.05) with significancy number 0.648. The conclusion was no significant difference between the effectiveness of the CBT group of 5 sessions and the CBT group of 12 sessions. There needs comparison of more than 5 sessions and less than 12 sessions for next research.

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Preliminary Evidence of the Short Allele of the Serotonin Transporter Gene Predicting Poor Response to Cognitive Behavior Therapy in Posttraumatic Stress Disorder

Cited by 103 publications

References 19 publications

Behavioural therapy based on distraction alleviates impaired fear extinction in male serotonin transporter knockout rats

Behavioural therapy based on distraction alleviates impaired fear extinction in male serotonin transporter knockout rats

Using Neurobiological Measures to Predict and Assess Treatment Outcome of Psychotherapy in Posttraumatic Stress Disorder: Systematic Review

Comparative Effectiveness of Cognitive Behavioral Therapy 5 Sessions and 12 Sessions Toward to Post Traumatic Stress Disorder on Post Flood Disaster Adolescent

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