Preliminary evidence that age and sex affect exercise-induced hTERT expression

Cluckey, Travis G.; Nieto, Nathan C.; Rodoni, Bridger; Traustadóttir, Tinna

doi:10.1016/j.exger.2017.06.003

Cited by 16 publications

(15 citation statements)

References 42 publications

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“…This could be due to the differences in the measurements or dose (type, intensity, frequency and duration) of PA. PA can also stimulate telomerase, a reverse transcriptase enzyme, activity which is responsible for maintaining telomere length [24]. A recent study reported that one single session of high-intensity interval cycling increased hTERT gene expression in young and older men but not in women [25]. hTERT is a functional protein of telomerase that acts as a limiting factor in functional telomerase activity and can therefore be used as an index of telomerase function.…”

Section: Discussionmentioning

confidence: 99%

Physical Activity and Telomeres in Old Age: A Longitudinal 10-Year Follow-Up Study

et al. 2020

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Background: Telomeres are crucial parts of chromosomes that protect the genome. They shorten every time the cell replicates, and shorter telomeres have been associated with increasing age and with many health behaviours. There is inconclusive evidence on the association between physical activity (PA) and telomere length. Objectives: To examine how leisure-time PA (LTPA) is associated with telomere length and telomere attrition during 10 years of follow-up in elderly people. Design: This study is a 10-year prospective follow-up study. Method: For this prospective study, we ex

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Section: Discussionmentioning

confidence: 99%

Physical Activity and Telomeres in Old Age: A Longitudinal 10-Year Follow-Up Study

et al. 2020

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“…To test this hypothesis, age- and gender-related differences in telomerase and shelterin responses at 30, 60, and 90 min after a high intensity interval cycling exercise were determined in PBMC of 11 young (22 years) and 8 older (60 years) men and women. A larger increase in telomerase activity, as assessed by TERT mRNA levels, was found in the young compared to the older group after exercise [78]. The second main finding of that study was the higher TERT response to the acute endurance exercise in men compared to women, in whom the response was negligible, independently of age.…”

Section: Telomere Regulation By Physical Activitymentioning

confidence: 96%

“…Another study showed that a 30-min treadmill running session was long enough to increase PBMC telomerase activity in 22 young healthy subjects including 11 women and 11 men [79]. Altogether, those recent studies confirm that the increasing telomerase activity after a single bout of exercise could be one of the mechanisms by which physical activity protects against aging [73,78,79].…”

Section: Telomere Regulation By Physical Activitymentioning

confidence: 97%

“…A very recent study tested whether an acute bout of exercise would induce a different response on telomerase activity in older vs. young individuals and whether this response would be gender-specific [78]. To test this hypothesis, age- and gender-related differences in telomerase and shelterin responses at 30, 60, and 90 min after a high intensity interval cycling exercise were determined in PBMC of 11 young (22 years) and 8 older (60 years) men and women.…”

Section: Telomere Regulation By Physical Activitymentioning

confidence: 99%

“…The second main finding of that study was the higher TERT response to the acute endurance exercise in men compared to women, in whom the response was negligible, independently of age. Those results showed that aging is associated with reduced telomerase activation in response to high-intensity cycling exercise in men [78]. Another study showed that a 30-min treadmill running session was long enough to increase PBMC telomerase activity in 22 young healthy subjects including 11 women and 11 men [79].…”

Section: Telomere Regulation By Physical Activitymentioning

confidence: 99%

See 2 more Smart Citations

Physical Activity and Nutrition: Two Promising Strategies for Telomere Maintenance?

2018

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As the world demographic structure is getting older, highlighting strategies to counteract age-related diseases is a major public health concern. Telomeres are nucleoprotein structures that serve as guardians of genome stability by ensuring protection against both cell death and senescence. A hallmark of biological aging, telomere health is determined throughout the lifespan by a combination of both genetic and non-genetic influences. This review summarizes data from recently published studies looking at the effect of lifestyle variables such as nutrition and physical activity on telomere dynamics.

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Aging Processes Are Affected by Energy Balance: Focused on the Effects of Nutrition and Physical Activity on Telomere Length

Gürel,

Pak,

Tek

2024

Curr Nutr Rep

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Purpose of Review The number and proportion of individuals aged 60 and over are increasing globally. The increase in the elderly population has important social and economic effects. Telomere length is an important marker for healthy aging. Here, we review the relevance between telomere length and energy balance by determining the effects of physical activity, nutrients, dietary patterns, and foods on healthy aging and telomere length with related studies. Recent Findings Evidence emphasizes the importance of telomere length and integrity for healthy aging. It also focuses on the importance of potential interventions such as physical activity and a healthy diet to improve this process. Summary We suggest that ensuring energy balance with regular physical activity and healthy diets can contribute to the aging process by protecting telomere length. In addition, different methods in studies, short and inconsistent durations, different types of exercise, different diet patterns, and non-standard foods have led to conflicting results. More studies are needed to elucidate molecular-based mechanisms.

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Preliminary evidence that age and sex affect exercise-induced hTERT expression

Cited by 16 publications

References 42 publications

Physical Activity and Telomeres in Old Age: A Longitudinal 10-Year Follow-Up Study

Physical Activity and Telomeres in Old Age: A Longitudinal 10-Year Follow-Up Study

Physical Activity and Nutrition: Two Promising Strategies for Telomere Maintenance?

Aging Processes Are Affected by Energy Balance: Focused on the Effects of Nutrition and Physical Activity on Telomere Length

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