Preliminary evidence that obese patients with obstructive sleep apnea/hypopnea syndrome are refractory to the acute beneficial metabolic effects of a very low calorie diet

Giordani, Ilaria; Malandrucco, Ilaria; Picconi, Fabiana; Longo, Susanna; Flaviani, Alessandra Di; Chioma, Laura; Moscatelli, Barbara; Donno, Silvia; Frontoni, Simona

doi:10.1007/s00592-013-0487-5

Cited by 4 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…OSAHS patients with MS presented higher levels of glucose than patients without MS, but the association between aldosterone and glucose levels failed to reach statistical significance. Experimental and clinical evidence support a pathophysiologic link between OSAHS, beta cell function and glucose metabolism [3],[38]. Moreover, several cross-sectional studies have reported direct correlations between aldosterone and insulin resistance [27],[30].…”

Section: Discussionmentioning

confidence: 97%

“…Elevated aldosterone levels have been pointed to lead not only to sodium retention and volume expansion, but also to increased inflammation and oxidative stress, which in turn promote insulin resistance, impaired pancreatic β cell function, endothelial dysfunction and hypertension [35],[36]. There is also evidence that aldosterone may worsen preexisting alterations in glucose and lipid metabolism [37],[38]. In addition, a recent study demonstrated that in patients with hypertension, plasma aldosterone levels were higher in the group with MS in spite of no differences in plasma renin activity between the groups with or without MS [10].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between Aldosterone and the Metabolic Syndrome in Patients with Obstructive Sleep Apnea Hypopnea Syndrome: Effect of Continuous Positive Airway Pressure Treatment

et al. 2014

View full text Add to dashboard Cite

BackgroundMetabolic syndrome (MS) occurs frequently in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). We hypothesized that aldosterone levels are elevated in OSAHS and associated with the presence of MS.MethodsWe studied 66 patients with OSAHS (33 with MS and 33 without MS) and 35 controls. The occurrence of the MS was analyzed according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) clinical criteria. Measurements of plasma renin activity (PRA), aldosterone, aldosterone:PRA ratio, creatinine, glucose, triglycerides, cholesterol and HDL cholesterol were obtained at baseline and after CPAP treatment.ResultsAldosterone levels were associated with the severity of OSAHS and higher than controls (p = 0.046). Significant differences in aldosterone levels were detected between OSAHS patients with and without MS (p = 0.041). A significant reduction was observed in the aldosterone levels in patients under CPAP treatment (p = 0.012).ConclusionThis study shows that aldosterone levels are elevated in OSAHS in comparison to controls, and that CPAP therapy reduces aldosterone levels. It also shows that aldosterone levels are associated with the presence of metabolic syndrome, suggesting that aldosterone excess might predispose or aggravate the metabolic and cardiovascular complications of OSAHS.Trial registrationThe study is not a randomized controlled trial and was not registered.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Relationship between Aldosterone and the Metabolic Syndrome in Patients with Obstructive Sleep Apnea Hypopnea Syndrome: Effect of Continuous Positive Airway Pressure Treatment

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The very low-calorie diet (VLCD) contains between 400 to 800 kcal/day and is indicated for individuals with a BMI >40 kg/m 2 who need to control their comorbidities 9,10. Its impact on the change in body composition in morbidly obese 11 and its benefits during the perioperative period of bariatric surgery have been shown in several studies 3,6,12,13. At our institution, patients with BMI>50 kg/m 2 had a weight loss approximately of 10% in 7.7 weeks with a VLCD 14.…”

Section: Introductionmentioning

confidence: 99%

Very low-calorie diet in candidates for bariatric surgery: change in body composition during rapid weight loss

Serafim¹,

Santo²,

Gadducci³

et al. 2019

Clinics

View full text Add to dashboard Cite

OBJECTIVE: To analyze the changes in the body composition of morbidly obese patients induced by a very low-calorie diet. METHODS: We evaluated 120 patients selected from a university hospital. Body composition was assessed before and after the diet provided during hospitalization, and changes in weight, body mass index, and neck, waist and hip circumferences were analyzed. Bioimpedance was used to obtain body fat and fat-free mass values. The data were categorized by gender, age, body mass index and diabetes diagnosis. RESULTS: The patients consumed the diet for 8 days. They presented a 5% weight loss (without significant difference among groups), which represented an 85% reduction in body fat. All changes in body circumference were statistically significant. There was greater weight loss and a greater reduction of body fat in men, but the elderly showed a significantly higher percentage of weight loss and greater reductions in body fat and fat-free mass. Greater reductions in body fat and fat-free mass were also observed in superobese patients. The changes in the diabetic participants did not differ significantly from those of the non-diabetic participants. CONCLUSIONS: The use of a VLCD before bariatric surgery led to a loss of weight at the expense of body fat over a short period, with no significant differences in the alteration of body composition according to gender, age, body mass index and diabetes status.

show abstract

“…OSAHS has severe effects on cognitive function, growth and development, and behavior of children (3). In addition, life quality also significantly decreases (4).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of minimally invasive tonsil surgery for treatment of obstructive sleep apnea-hypopnea syndrome in children

Zhang

Wang

Zhou

et al. 2017

Braz J Med Biol Res

View full text Add to dashboard Cite

This study aimed to investigate the efficacy of minimally invasive tonsil surgery for the treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS) in children. Tonsil ablation or turbinate reduction was performed on 49 pediatric patients with OSAHS by minimally invasive tonsil surgery. In order to evaluate the efficacy of surgery, a comparison was conducted between pre-operation and post-operation data in terms of the symptoms, signs and polysomnography test. Total effectiveness rate of the surgery was 83.7%. Subgroup analysis was also performed based on the severity of their conditions: mild, moderate, and severe groups had an effectiveness rate of 90.0, 88.9, and 66.7%, respectively (Hc=6.665, P<0.05). Postoperatively, the apnea-hypopnea index, the minimum oxygen saturation (SaO2), and corresponding symptoms improved compared to pre-operation conditions (P<0.05). Minimally invasive tonsil surgery was a safe and effective method for treating OSAHS in children.

show abstract

Preliminary evidence that obese patients with obstructive sleep apnea/hypopnea syndrome are refractory to the acute beneficial metabolic effects of a very low calorie diet

Cited by 4 publications

References 31 publications

Relationship between Aldosterone and the Metabolic Syndrome in Patients with Obstructive Sleep Apnea Hypopnea Syndrome: Effect of Continuous Positive Airway Pressure Treatment

Relationship between Aldosterone and the Metabolic Syndrome in Patients with Obstructive Sleep Apnea Hypopnea Syndrome: Effect of Continuous Positive Airway Pressure Treatment

Very low-calorie diet in candidates for bariatric surgery: change in body composition during rapid weight loss

Efficacy of minimally invasive tonsil surgery for treatment of obstructive sleep apnea-hypopnea syndrome in children

Contact Info

Product

Resources

About