Preliminary experience with precipitating hydrophobic injectable liquid in brain arteriovenous malformations

Koçer, Naci; Hanımoğlu, Hakan; Batur, Şebnem; Kandemirli, Sedat Giray; Kızılkılıç, Osman; Sanus, Zihni; Öz, Büğe; Işlak, Civan; Kaynar, Mehmet Yaşar

doi:10.5152/dir.2015.15283

Cited by 43 publications

(45 citation statements)

References 16 publications

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“…Three concentrations are available: 25%, 30%, and 35% (concentration of polymer by weight). Preliminary clinical data is available for PHIL ™ used in treatment of cerebral AVMs and cranial and spinal dural arteriovenous fistulas [81,80,82]. The study by Kocer et al .…”

Section: Commercially Available Materialsmentioning

confidence: 99%

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Polymeric materials for embolic and chemoembolic applications

Poursaid

Jensen

Huo

et al. 2016

Journal of Controlled Release

117

103

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Percutaneous transcatheter embolization procedures involve the selective occlusion of blood vessels. Occlusive agents, referred to as embolics, vary in material characteristics including chemical composition, mechanical properties, and the ability to concurrently deliver drugs. Commercially available polymeric embolics range from gelatin foam to synthetic polymers such as poly(vinyl alcohol). Current systems under investigation include tunable, bioresorbable microspheres composed of chitosan or poly(ethylene glycol) derivatives, in situ gelling liquid embolics with improved safety profiles, and radiopaque embolics that are trackable in vivo. This article reviews commercially available materials used for embolization as well as polymeric materials that are under investigation.

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Section: Commercially Available Materialsmentioning

confidence: 99%

“…The study by Kocer et al . compared AVMs first treated with a liquid embolic followed by resection [81]. Either PHIL ™ was used alone or in combination with Onyx ® .…”

Section: Commercially Available Materialsmentioning

confidence: 99%

Polymeric materials for embolic and chemoembolic applications

Poursaid

Jensen

Huo

et al. 2016

Journal of Controlled Release

117

103

View full text Add to dashboard Cite

show abstract

“…Precipitating hydrophobic injectable liquid (PHIL; MicroVention, Tustin, California, USA) is a novel permanent liquid embolic agent which may allow better intravascular penetration than ethylene vinyl alcohol copolymer (Onyx; ev3 Neurovascular, Irvine, California, USA). [2] However, the literature regarding the use of PHIL for the treatment of intracranial vascular malformations is presently very limited. [234] We describe a case of a patient with a complex posterior fossa DAVF which was successfully embolized with PHIL.…”

mentioning

confidence: 99%

“…[2] However, the literature regarding the use of PHIL for the treatment of intracranial vascular malformations is presently very limited. [234] We describe a case of a patient with a complex posterior fossa DAVF which was successfully embolized with PHIL.…”

mentioning

confidence: 99%

Embolization of a Complex Posterior Fossa Dural Arteriovenous Fistula with Precipitating Hydrophobic Injectable Liquid

Ding

McGuinness

Brew

2016

Journal of Neurosciences in Rural Practice

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“…Onyx causes susceptibility artifacts on gradient and susceptibility-weighted images, which are not seen with PHIL. 2 Plug formation with PHIL is faster than with Onyx due to fewer layering effects, resulting in reduced fluoroscopy time and consequent radiation dose. 2 There is minimal wastage with PHIL because it comes in a prefilled syringe in contrast to Onyx.…”

mentioning

confidence: 99%