Preliminary experience with the use of an autologous platelet-rich fibrin membrane for urethroplasty coverage in distal hypospadias surgery

Protective effect of platelet‐rich plasma on urethral injury model of male rats

“…PRP treatment is an accepted treatment method in a wide range of medical fields, including orthopedics, plastic surgery, and dermatology . Its use in urology has been reported to be beneficial in hypospadias surgery, but its application in the treatment of UI and prevention for US has not been reported previously. PRP, which has a critical effect on wound healing and has been used in fibrotic diseases, comprises a concentration of numerous protein growth factors, such as vascular endothelial growth factor (VEGF), insulin‐like growth factor (IGF), TGF‐β, and fibroblast growth factor (FGF).…”

“…PRP is widely used in orthopedic and dermatological procedures and has been reported to be beneficial in hypospadias surgery, as well . However, there are no reports of its use in a urethral injury (UI) model thus far.…”

Autologous platelet‐rich plasma covering urethroplasty versus dartos flap in distal hypospadias repair: A prospective randomized study

“…found that the PRF patch seems to be a safe and efficient covering technique. This procedure is an additional approach to coverage for hypospadias surgery …”

“…This procedure is an additional approach to coverage for hypospadias surgery. 21 El-Galley et al showed that the concentration of epidermal growth factor is significantly lower in the foreskins of boys with hypospadias than in boys with a normal penis. 22 The rate of complications in group A with PRP coverage was less than group B with a significant difference (P = 0.040), also it was comparable with those reported in the literature for distal hypospadias repair, [11][12][13][14][15][16][17][18][19][20][21][22][23][24] indicating that this technique had no adverse effects.…”

Effective factors for success in hypospadias surgery

“…Bu amaçla penis dorsalinden ya da anterior kısmından hazırlanacak bir flep (Resim 8a, 8b, 8c) kullanılabile-ceği gibi posterior yerleşimli olgularda skrotal dartos tabakası ya da tunika vaginalis flebi de kullanılabilir. Ayrıca fibrin yapıştırıcı kullanılması da önerilen teknikler arasındadır (23) . Dhua ve ark.…”