2023
DOI: 10.3390/diagnostics13061175
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Preliminary Findings of the Role of FAPi in Prostate Cancer Theranostics

Abstract: Prostate cancer (PCa) is the most frequently diagnosed cancer worldwide and the second most common cause of cancer-related deaths among men. Progress in molecular imaging has magnified its clinical management; however, an unmet clinical need involves the identification of new imaging biomarkers that complement the gold standard of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) in cases of clinically significant PCa that do not express PSMA. Fibroblast activation protein (FAP) is a… Show more

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Cited by 8 publications
(3 citation statements)
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“…PCa often demonstrates varying levels of aggressiveness across different regions of the tumor due to its inherent heterogeneity [29]. To quantify this variation, a grading system is used to assign grades to the two primary areas of cancerous tissue under examination, and the sum of these grades determines the overall Gleason score (GS).…”
Section: Gleason Scorementioning
confidence: 99%
“…PCa often demonstrates varying levels of aggressiveness across different regions of the tumor due to its inherent heterogeneity [29]. To quantify this variation, a grading system is used to assign grades to the two primary areas of cancerous tissue under examination, and the sum of these grades determines the overall Gleason score (GS).…”
Section: Gleason Scorementioning
confidence: 99%
“…CAFs, also known as reactive fibroblasts or myofibroblasts, are found in a variety of malignant tumours, including head and neck malignancies other than TC ( 20 , 21 ). FAP expression may also variate according to the solid tumours’ grading, such as in prostate cancer ( 22 , 23 ). Despite CAFs being stromal cells, which are part and parcel of neoplastic lesions, they do not express epithelial, endothelial, or leukocyte markers and are notably devoid of oncogene mutations ( 24 ).…”
Section: Introductionmentioning
confidence: 99%
“…On the other side, labeling FAPI with 18 F, that has a longer half-life and lower positron energy than 68 Ga (half-life of 110 and positron energy of 0.65 MeV vs. 68 and 1.9 MeV), would reduce the costs of production and facilitate its distribution together with improved spatial resolution [26]. Furthermore, besides the use of radiolabelled FAPI tracers for diagnostic purposes, DOTA chelator in the molecular structure allows the coupling of FAPI molecules with either alpha-or beta-emitting radioisotopes (i.e., Lutetium-177, Yttrium-90, Actinium-225), exploiting their potential role as a new anti-cancer radioligand therapy (RLT) in a theranostic perspective [23,24,27]. Like [ 18 F]FDG, wound healing, fibrosis and inflammation can be visualized using FAPI-based tracers PET imaging [25].…”
Section: Introductionmentioning
confidence: 99%