Sustainability is a key factor in petroleum industry development, determining whether an enterprise has the ability to maintain high-quality safety management in the long term. In order to reduce occupational injuries and accidents, and to improve safety in the petroleum industry, this study proposes a hybrid approach based on the fuzzy analytical hierarchy process (FAHP), human factors, and the fuzzy comprehensive evaluation (FCE) method in order to assess safety performance in a petroleum enterprise. This paper is comprised of four stages. In the first stage, a model is constructed for assessing the safety of the petroleum industry based on a literature review. In the second stage, we use the FAHP to determine the weights of five factors and 19 sub-factors. In the third stage, employees are the subjects of a questionnaire on the safety performance of the petroleum enterprise. According to the analysis of the assessment results, we focus on improving employees’ safety behaviors and mental health. A second round of questionnaires is distributed to the employees, and a second set of assessment results obtained. Finally, the results of the two evaluations are compared, and the effectiveness of the combination of FAHP, human factors, and FCE is verified.