Preliminary in vitro hemocompatibility assessment of biopolymeric hydrogels for versatile biomedical applications

Multifunctional Molybdenum-Based Nanoclusters Engineered Gelatin Methacryloyl as In Situ Photo-Cross-Linkable Hybrid Hydrogel Dressings for Enhanced Wound Healing

“…It is, therefore, crucial to ensure that these materials are hemocompatible to prevent undesirable reactions such as clot formation, platelet activation, and immune responses, all of which can hinder the healing process . Hemocompatible hydrogels play a key role in facilitating healing by fostering an environment conducive to cell proliferation and tissue regeneration while avoiding cytotoxic effects or systemic toxicity resulting from hemolysis . The clinical application of various hybrid hydrogels is typically limited by the challenges associated with incorporating nanomaterials into the hydrogels .…”

“…These nanomaterials are not readily eliminable from the animal body and their administration in larger quantities is hence unfeasible. The hemolysis assay specifically measures the degree to which a hydrogel causes the destruction of RBC, leading to the release of hemoglobin into the plasma . Hemolysis percentages less than 5% are generally acceptable for biomedical applications, while higher percentages may require further investigation and optimization of the hydrogel .…”