2006
DOI: 10.2176/nmc.46.387
|View full text |Cite
|
Sign up to set email alerts
|

Preliminary Individualized Chemotherapy for Malignant Astrocytomas Based on O6-Methylguanine-Deoxyribonucleic Acid Methyltransferase Methylation Analysis

Abstract: O 6 -methylguanine-deoxyribonucleic acid methyltransferase gene (MGMT) methylation is apparently correlated with responsiveness to nitrosourea chemotherapy, suggesting this alkylating agent should be effective against MGMT-methylated tumors. MGMT appears not to be linked to platinum resistance, so platinum chemotherapy should be used for MGMT-unmethylated tumors. This study was a preliminary trial of individualized chemotherapy based on MGMT methylation status in a total of 20 patients with newly diagnosed mal… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
8
0

Year Published

2008
2008
2018
2018

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 10 publications
(9 citation statements)
references
References 22 publications
1
8
0
Order By: Relevance
“…Studies investigating the relationship between MGMT activity status in canine lymphoma and response to LPP may be warranted. In humans with malignant astrocytoma, MGMT‐methylation may be associated with increased response to PAV (procarbazine, nimustine, vincristine) …”
Section: Discussionmentioning
confidence: 99%
“…Studies investigating the relationship between MGMT activity status in canine lymphoma and response to LPP may be warranted. In humans with malignant astrocytoma, MGMT‐methylation may be associated with increased response to PAV (procarbazine, nimustine, vincristine) …”
Section: Discussionmentioning
confidence: 99%
“…Promoter hypermethylation of the MGMT gene was determined by the methylationspecific polymerase chain reaction (MS-PCR) (16). The PCR was performed with primers specific for either methylated or modified unmethylated DNA, as described previously (17)(18)(19).…”
Section: Methodsmentioning
confidence: 99%
“…The primer sequences of MGMT for the methylated and unmethylated reactions were as reported previously (22). The PCR was carried out as described previously (48,49). Amplified products were electrophoresed on 3% agarose gels and were visualized with ethidium bromide.…”
Section: Methodsmentioning
confidence: 99%