Preliminary investigation comparing a detomidine continuous rate infusion combined with either morphine or buprenorphine for standing sedation in horses

Potter, Joanna J; MacFarlane, Paul; Love, Edgar J.; Tremaine, Henry; Taylor, Polly; Murrell, Joanna C

doi:10.1111/vaa.12316

Cited by 25 publications

(22 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Detomidine CRIs have been used under clinical conditions after loading doses of 7.5-15 lg/kg bwt in prospective studies [8][9][10][11], and of 7.5 AE 1.87 lg/kg bwt (mean AE s.d.) in a retrospective study with 51 horses [12].…”

Section: Introductionmentioning

confidence: 99%

Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses

Gozalo-Marcilla

Oliveira

Fonseca

et al. 2018

Equine Veterinary Journal

View full text Add to dashboard Cite

Summary Background Standing surgery avoids the risks of general anaesthesia in horses. Objectives To assess sedation, antinociception and gastrointestinal motility in standing horses after a detomidine loading dose and 2‐h constant rate intravenous (i.v.) infusion, with or without methadone. Study design Blinded, randomised, crossover with seven healthy adult cross‐bred horses, three geldings and four females (404 ± 22 kg). Methods Five i.v. treatments were administered to all horses with 1‐week washout period: saline (SAL), detomidine low (2.5 μg/kg bwt + 6.25 μg/kg bwt/h) (DL) and high doses (5 μg/kg bwt + 12.5 μg/kg bwt/h) (DH) alone or combined with methadone (0.2 mg/kg bwt + 0.05 mg/kg bwt/h), (DLM) and (DHM), respectively. Height of head above the ground (HHAG), electrical (ET), thermal (TT) and mechanical (MT) nociceptive thresholds and gastrointestinal motility were evaluated at predetermined times between 5 and 240 min. A mixed effect model and Kruskal–Wallis test were used to analyse normally and non‐normally distributed data, respectively. Results Sedation (<50% basal HHAG) was achieved for the duration of the infusion, and for an additional 15 min in DH and DHM groups. Nociceptive thresholds were higher than baseline, to the greatest degree and the longest duration, with DHM (ET and TT for 135 min and MT for 150 min). After DH, TT was significantly higher than baseline from 30 to 120 min and MT from 15 to 135 min. After DLM, ET was increased at 90 min, TT at 30 min and MT for 120 min. Gastrointestinal motility was reduced for up to 135 min after DL, 150 min after DLM and 210 min after DH and DHM. Main limitations Nociceptive thresholds are not equivalent to surgical stimuli. Conclusion Methadone with the highest detomidine dose (DHM) may provide sufficient sedation and analgesia for standing surgical procedures and warrants further investigation.

show abstract

Section: Introductionmentioning

confidence: 99%

Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses

Gozalo-Marcilla

Oliveira

Fonseca

et al. 2018

Equine Veterinary Journal

View full text Add to dashboard Cite

show abstract

“…), with horses that received 0.1 mg/kg bwt morphine for sedation for standing surgery showing no intraoperative ataxia or locomotor activity (Potter et al . ).…”

Section: Systemic Analgesicsmentioning

confidence: 97%

“…The use of buprenorphine in combination with a detomidine CRI and local anaesthetic blocks for standing surgery resulted in more complications in the post‐operative period than the use of morphine (Potter et al . ). All horses that received buprenorphine, box‐walked and had muscle tremors or shivered and half of the horses were hypersensitive to noise.…”

Section: Systemic Analgesicsmentioning

confidence: 97%

Perioperative pain management in horses

McFadzean

Love

2018

Equine Veterinary Education

View full text Add to dashboard Cite

Summary The inability to talk does not diminish an animal's ability to experience pain, although it may hinder its recognition and therefore lead to the under‐treatment of pain. Pain assessment and treatment in horses has advanced considerably with the recent publication of numerous research papers in this area. This review will summarise these research findings and suggest how advances in knowledge of perioperative pain management can be implemented in equine clinical practice.

show abstract

“…Studies reporting unwanted side effects are generally from pain‐free horses undergoing research; the more ‘clinical’ studies usually show beneficial effects (Potter et al . ; Mircica et al . ; Senior et al .…”

Section: Multimodal Analgesiamentioning

confidence: 99%

Update in advances in pain management for the equine practitioner

Taylor¹,

Senior

2018

Equine Veterinary Education

View full text Add to dashboard Cite

Preliminary investigation comparing a detomidine continuous rate infusion combined with either morphine or buprenorphine for standing sedation in horses

Abstract: At the doses used, buprenorphine produced greater sedation but more post-operative complications than morphine. However, Type I or Type II errors cannot be excluded and larger studies are required to confirm these findings.

Cited by 25 publications

References 10 publications

Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses

Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses

Perioperative pain management in horses

Update in advances in pain management for the equine practitioner

Contact Info

Product

Resources

About