Preliminary investigation for wound healing and anti-inflammatory effects of Bambusa vulgaris leaves in rats

Abstract

BackgroundBambusa vulgaris (Family: Poaceae) used in Ayurveda for paralytic complaints, inflammatory disorders and externally to skin disorders. It has various medicinal uses with good nutritional composition and a rich source of vitamins, proteins, amino acid, beta-carotene and phenolic compounds.ObjectiveThe present study was aimed to evaluate wound healing and anti-inflammatory potential of ethanol extract of B. vulgaris leaves in rats.Materials and methodsThe B. vulgaris leaves were evaluated for wound healing on incision and excision wound methods. Anti-inflammatory effect was evaluated by measurement of paw edema in carrageenan-induced inflammation in rats. Ethyl acetate (BVL-A) and aqueous (BVL-B) fractions from the ethanol extract of leaves were screened for wound healing effects by measuring tensile strength and biochemical parameters in incision wound method. The wound contraction area, antioxidant status and histopathological studies were done in excision wound method.ResultsTensile strength and hydroxyproline level of 5% w/w ointment of BVL-A and BVL-B treated groups were found significantly (P < 0.01) higher and comparable to the reference group. The histopathological study showed the proliferation of collagen, fibrous tissue, and capillaries with epidermal covering at the margin of the wound. The percent inhibition of paw edema was significantly decrease by increasing concentration of BVL-A and BVL-B fractions. In addition, it was found that B. vulgaris possesses antioxidant properties, by its ability to increase antioxidants level.ConclusionsThe results obtained in the present study were indicated that ethyl acetate fraction of B. vulgaris leaves inhibits paw edema and accelerates cutaneous wound healing.

Phyotochemical Properties of Acalypha indica (L), and its Antimicrobial Potential against Human Pathogens

“…Among five solvents used, the maximum extract was obtained in ethanol (0.56g) followed by acetone (0.26g) ( Table 1). Similarly, ethanol solvent is optimum for maximum extract in Dodonaea viscosa (Khurram et al, 2009), Boerhavia diffusa (Apu et al, 2012), Pavatta indica (Gupta et al, 2013) and Bambusa vulgaris (Lodhi et al, (2016). On the other hand, Ujwal et al, (2007) reported good extract yield in Pongamia pinnata using petroleum ether and ethyl acetate.…”

“…On the other hand, Bargah et al, (2015) revealed ethanol and aqueous extracts of Moringa pterygosperma contained various phytochemicals such as alkaloid, flavonoid, glycoside, phenol, saponin, steroid and tannin further, these extract used as antioxidants, antifungal, antibacterial, anti abortifacient. Ethanol extract from Bambusa vulgaris, found terpenoid, flavonoid, carbohydrate, protein, tannin, and glycoside with wound healing and anti inflammatory properties (Lodhi et al, 2016). These results suggested different phytochemicals presence depends on the plant nature and their solvent system used.…”

NED416, a novel synthetic Sirt1 activator, promotes cutaneous wound healing via the MAPK/Rho pathway

“…Sirt1 activators, including NEd416, regulate wound healing mainly in the later phases. However, extracts from Aloe vera and Vitis vinifera regulate the overall process of wound healing (38,39).…”

Evaluation of the Wound Healing Potential of Teucrioside

“…Because they have low viability and various detrimental side effects. 5,6 Therefore, plant derived drugs is under great demand due to common belief that they are safe, reliable and effective. Agents with wound healing potential, which are obtained from natural and synthetic bioactive materials have the antioxidant, chelation and antimicrobial activities; and may act by one or more of these mechanisms.…”