Preliminary investigation of anticancer activity by determining the DNA binding and antioxidant potency of new ferrocene incorporated N,N′,N″-trisubstituted phenylguanidines

Antioxidant and Anticancer Properties of Functionalized Ferrocene with Hydroxycinnamate Derivatives—An Integrated Experimental and Theoretical Study

“…Besides the complexes of transition metals such as Pt, Ru, Os, and Ir known for anti-cancer activity, bis­(η 5 -cyclopentadienyl)­iron (Fc, ferrocene) is a widely used structure in biomedicinal chemistry. − Chemical modification of ferrocene by substitution on the cyclopentadienyl rings causes significant changes in the chemical properties; such as solubility, hydrophobicity or lipophilicity, and air/water stability; or biological properties, such as toxicity and antioxidant activity. The ferroquine and its analogue compounds were discovered to be effective to treat malaria disease since the 1990s. − Moreover, ferrocifen, ferrociphenols, , and ferrocene-functionalized Ru­(II)-arene complexe, among others − showed the inhibiting of proliferation of cancer growth toward different cancer cell lines. It is noteworthy that the oxidation of ferrocene to ferrocenium cations and the reversible reduction process are reported to be feasible in biological systems and are very useful in the free radical scavenging processes as they can eliminate several harmful free radicals such as HO • and O 2 •– .…”

“…For example, Mu and co-worker reported that the ferrocene-functionalized Ru complex enhanced antioxidant activity in DPPH • scavenging activity and showed good cytotoxicity against HT19 human colon cancer cells while the parent molecules were inactive . DPPH • scavenging activity by ferrocene-based thioureas and ferrocene-based guanidine was also reported to be directly related to the anticancer properties of subjective compounds. In our view, the functionalization of ferrocene with a natural antioxidant is a promising approach toward metallodrugs, as it combines the stability and the biochemical versatility of ferrocene with the readily antioxidant activity of natural compounds.…”

The DNA threat probing of some chromophores using UV/VIS spectroscopy

“…The chromophoric dye molecules interact with biologically important macromolecules like protein and DNA, and investigating their interactive mode is important both from toxic and beneficial point of view of these chromophoric molecules. The literature study shows that small molecules interact with DNA through non covalent mode of interactions like electrostatic, groove binding and intercalative causing structural and functional changes in DNA molecule (Rehman et al, 2015) and the DNA binding constant was calculated according to the following Host Guest equation 1 (Gul et al, 2014). The binding of chromophores with DNA were found as faction of pH, in other words we can say that different binding patterns and binding abilities were generated with change in pH.…”

Anticancer and biological properties of new axially disubstituted silicon phthalocyanines

“…The percentage G–C base pair content differs in living species. 41 However, plant and animal DNA models differ in the size of major and minor grooves and chain lengths. 42 Pesticides are important compounds that combat different pests.…”