Preliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1α in SARS-Cov-2 infected patients

Uzunçakmak, Sevgi Karabulut; Naldan, Muhammet Emin; Dirican, Ebubekir; Kerget, Ferhan; Halıcı, Zekai

doi:10.1007/s11033-022-07710-9

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…C-reactive protein is used to follow many disease progressions as well as COVID-19 infections. 16 , 17 Increased CRP value was associated with disease and disease severity. Comorbid diseases also contribute to high CRP levels.…”

Section: Introductionmentioning

confidence: 96%

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SARS-CoV-2 Infection and Candidate Biomarkers

Uzunçakmak¹

2023

Eurasian J Med

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Severe acute respiratory syndrome coronavirus 2 is a virus that can still infect individuals and whose deadly effects continue despite the current vaccines and drugs. Since 2019, many studies on the pathogenesis of the disease have been completed and continue to be done. In addition to the diagnosis and treatment of the disease, many molecules that can be markers of the disease have been investigated. In the early stages of the pandemic, many nonspecific and infection-related laboratory findings and chest computed tomography were used to obtain information about the diagnosis of the disease. The more individual molecules became associated with the disease yet. The purpose of this review is to summarize the impact and role of many molecules associated with coronavirus disease-2019 infection that have been previously used and newly revealed. Numerous studies are summarized in this review. The obtained data show that previously used laboratory findings and new potential biomarkers are not specific to the disease. New potential biomarkers have been associated with the severity of the disease itself, as can be seen with lung imaging and even with routine laboratory findings. One of the important points that are seen frequently in studies is that the effectiveness of these molecules has been shown not only in coronavirus disease-2019 infection but also in many other diseases. This removes the pathogenesis of the disease from being a unique mechanism created by the Severe acute respiratory syndrome coronavirus 2 and provides a general perspective formed by viral or bacterial infections. However, there are still many molecular changes that need to be investigated. Future studies will continue to update themselves with the mutations of the virus.

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Section: Introductionmentioning

confidence: 96%

“…Higher HF-1α expression was determined in severe COVID-19 patients than healthy individuals. 16 This may be a sign of decreased oxygen supply in the lungs as well as a sign of course in COVID-19 infection.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 Infection and Candidate Biomarkers

Uzunçakmak¹

2023

Eurasian J Med

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“… 82 - 87 In addition, genetic studies have shown that PAPP-A, STC-2, and HIF-1α gene expression is higher in patients with a severe clinical course. 88 In a similar study examining CYP2E1 and caspase-3 gene expression in patients with COVID-19 infection, it was found that caspase-3 expression increased but CYP2E1 expression decreased in COVID-19 patients compared to healthy individuals. 89 …”

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confidence: 94%

Review of Medical Studies on COVID-19 During the Pandemic Period

Aksakal¹,

Kerget²

2023

Eurasian J Med

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Due to the COVID-19 pandemic, both the university hospital and the city hospital have faced a significant patient load in our city. During this period, academic articles were written that contributed significantly to the literature on both hospitals struggling with patient density. In our study, we aimed to compile medical articles about COVID-19 in our city using the Web of Science and PubMed database.

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Identification of key genes and biological pathways in chronic obstructive pulmonary disease using bioinformatics and next generation sequencing data analysis

Vastrad,

Vastrad

2024

Preprint

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Identification of accurate biomarkers is still particularly urgent for improving the poor survival of chronic obstructive pulmonary disease (COPD) patients. In this investigation, we aimed to identity the potential biomarkers in COPD via bioinformatics and next generation sequencing (NGS) data analysis. In this investigation, the differentially expressed genes (DEGs) in COPD were identified using NGS dataset (GSE239897) from Gene Expression Omnibus (GEO) database. Subsequently, gene ontology (GO) and pathway enrichment analysis was conducted to evaluate the underlying molecular mechanisms involved in progression of COPD. Protein-protein interaction (PPI), modules, miRNA-hub gene regulatory network and TF-hub gene regulatory network analysis were performed to determine the hub genes, miRNAs and TFs. The receiver operating characteristic (ROC) analysis was performed to determine the diagnostic value of hub genes. A total of 956 overlapping DEGs (478 up regulated and 478 down regulated genes) were identified in the NGS dataset. DEGs were mainly associated with GO functional terms and pathways in cellular response to stimulus. response to stimulus, immune system and neutrophil degranulation. There were 10 hub genes (MYC, LMNA, VCAM1, MAPK6, DDX3X, SHMT2, PHGDH, S100A9, FKBP5 and RPS6KA2) identified by PPI, modules, miRNA-hub gene regulatory network and TF-hub gene regulatory network analysis. In conclusion, the DEGs, relative GO terms, pathways and hub genes identified in the present investigation might aid in understanding of the molecular mechanisms underlying COPD progression and provide potential molecular targets and biomarkers for COPD.

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Preliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1α in SARS-Cov-2 infected patients

Cited by 3 publications

References 40 publications

SARS-CoV-2 Infection and Candidate Biomarkers

SARS-CoV-2 Infection and Candidate Biomarkers

Review of Medical Studies on COVID-19 During the Pandemic Period

Identification of key genes and biological pathways in chronic obstructive pulmonary disease using bioinformatics and next generation sequencing data analysis

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