Preliminary Investigation of Pain-Related Changes in Cerebral Blood Volume in Patients With Phantom Limb Pain

Seo, Cheong Hoon; Park, Chang-Hyun; Jung, Myung Hun; Jang, Soyeon; Joo, So Young; Kang, Yoonkyeong; Ohn, Suk Hoon

doi:10.1016/j.apmr.2017.03.010

Cited by 9 publications

(14 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The patterns of increased diffusivity, and the correlation between diffusivity and pain intensity, were very similar with a previous CBV study [11]. We observed increased CBV in the ACC and OFC of both hemispheres regardless of the amputation side, which are regions associated with emotion in the cerebral pain network.…”

Section: Discussionsupporting

confidence: 89%

“…To our knowledge, this study is the first to show white matter alterations in the pain network induced by phantom limb pain. Moreover, this analysis of structural connectivity by DTI complements our previous study, proving that CBV change was associated with the emotional domain of the pain network in these patients [11].…”

Section: Discussionsupporting

confidence: 79%

“…This was an exploratory case-control study. We used the DTI data acquired at the time of CBV MRI in our previous study [11]. Thus, ten patients with phantom limb pain (43.8 ± 3.4 yr, range: 37–48 yr, 1 woman) and sixteen age- and sex-matched healthy controls (41.7 ± 2.2 yr, range: 39–46 yr, 7 women) participated.…”

Section: Methodsmentioning

confidence: 99%

“…The emotional domain of the pain network is responsible for reacting to pain with negative emotional events and memories and involves the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), amygdala, and insula [10]. We also noted that increased cerebral blood volume (CBV) in the ACC and the OFC reflected a functional reorganization of the emotion-related pain network in patients with phantom limb pain [11].…”

Section: Introductionmentioning

confidence: 99%

“…We hypothesized that patients with phantom limb pain after amputation would have changes not only in the gray matter but also in the white matter. In the present study, we therefore aimed to analyze DTI data to identify the white matter link to the pain network in the same subjects who participated in our previous CBV study [11].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Increased white matter diffusivity associated with phantom limb pain

et al. 2019

Self Cite

View full text Add to dashboard Cite

BackgroundWe utilized diffusion tensor imaging (DTI) to evaluate the cerebral white matter changes that are associated with phantom limb pain in patients with unilateral arm amputation. It was anticipated that this would complement previous research in which we had shown that changes in cerebral blood volume were associated with the cerebral pain network.MethodsTen patients with phantom limb pain due to unilateral arm amputation and sixteen healthy age-matched controls were enrolled. The intensity of phantom limb pain was measured by the visual analogue scale (VAS) and depressive mood was assessed by the Hamilton depression rating scale. Diffusion tensor-derived parameters, including fractional anisotropy, mean diffusivity, axial diffusivity (AD), and radial diffusivity (RD), were computed from the DTI.ResultsCompared with controls, the cases had alterations in the cerebral white matter as a consequence of phantom limb pain, manifesting a higher AD of white matter in both hemispheres symmetrically after adjusting for individual depressive moods. In addition, there were associations between the RD of white matter and VAS scores primarily in the hemispheres related to the missing hand and in the corpus callosum.ConclusionsThe phantom limb pain after unilateral arm amputation induced plasticity in the white matter. We conclude that loss of white matter integrity, particularly in the hemisphere connected with the missing hand, is significantly correlated with phantom limb pain.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 79%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Increased white matter diffusivity associated with phantom limb pain

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

Does the presence of chronic pain affect scores on cognitive screening tests/brief cognitive measures for dementia? A systematic review and meta-analysis

Fradera,

McLaren,

Gadon

et al. 2024

The Clinical Neuropsychologist

View full text Add to dashboard Cite

Thermographic Evaluation, Residual Limb Skin Sensitivity, and Adaptation to the Prosthesis of Individuals with Lower-Limb Amputation with Prosthesis Provided by the Universal Health System

et al. 2023

View full text Add to dashboard Cite

Introduction Prosthesis fixation is considered the central point for functionality, which promotes social reintegration of the individual with amputation. The deficits in the making of the prosthetic socket may trigger excessive friction on the residual limb and socket discomfort, possibly leading to a poor adaptation and consequent reduction of activity. Thermography is an evaluation and diagnostic method that may aid in the verification of the functionality of the prosthesis. The objective of the study was to analyze the superficial thermal distribution characteristics, the skin sensitivity of the residual limb, and the adaptation to the prosthesis of individuals with lower-limb amputation with prostheses provided by the Universal Health System. Materials and Methods Sixteen individuals of both genders with unilateral lower-limb amputation with ages between 18 and 64 years were recruited. The data collection protocol was composed of completing the physiotherapeutic evaluation form, assessment of residual limb skin sensitivity, application of the Prosthesis Evaluation Questionnaire (PEQ), treadmill walk for 10 minutes, thermographic evaluation immediately after the removal of the prosthesis, and lastly postacclimatization thermographic assessment. Results Before the acclimatization, the region of the L3 dermatome of those who had altered sensitivity, the maximum (31.43°C), mean (28.97°C), and minimum (28.27°C) temperatures were significantly lower compared with those who had normal sensitivity (32.81°C, 29.68°C, and 28.91°C, respectively) (P < 0.05). Regarding the period after the acclimatization, there was no significant difference in the comparison performed between temperature and sensitivity. The individuals with transtibial amputation obtained results above the overall median for the PEQ items, whereas the individuals with transfemoral amputation obtained results above the overall median for the “total score.” There is a strong negative relationship between the mean temperature of the residual limb extremity with item “utility” in the preacclimatization moment and a strong negative relationship between the mean and minimum temperatures at the residual limb extremity with the “residual limb health” item at the moment after the acclimatization. There is no association between the PEQ items and residual limb sensitivity. Conclusions One may conclude that high temperatures at the postacclimatization moment indicate areas of friction that trigger a poor adaptation of the residual limb with the prosthetic socket, in which case the development of new strategies for improving the quality of the prostheses supplied is suggested. Clinical Relevance Thermography helps in evaluating the residual limb and adapting the prosthesis, as it is a noninvasive clinical assessment tool. Thermography aids health professionals for management of the patient with amputation in the preprosthesis and postprosthesis phases.

show abstract

Preliminary Investigation of Pain-Related Changes in Cerebral Blood Volume in Patients With Phantom Limb Pain

Cited by 9 publications

References 29 publications

Increased white matter diffusivity associated with phantom limb pain

Increased white matter diffusivity associated with phantom limb pain

Does the presence of chronic pain affect scores on cognitive screening tests/brief cognitive measures for dementia? A systematic review and meta-analysis

Thermographic Evaluation, Residual Limb Skin Sensitivity, and Adaptation to the Prosthesis of Individuals with Lower-Limb Amputation with Prosthesis Provided by the Universal Health System

Contact Info

Product

Resources

About