Preliminary investigation of the influence of CREB1 gene polymorphisms on cognitive dysfunction in Chinese patients with major depression

Guo, Junhui; Liu, Zhongchun; Dai, Hong; Zhu, Zhanyong; Wang, Huiling; Yang, Chaowu; Xiao, Ling; Huang, Yonglan; Wang, Gaohua

doi:10.3109/00207454.2013.816956

Cited by 9 publications

(5 citation statements)

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“…CREB-BDNF pathway is closely related to many neurobiological processes, including synapse and neural plasticity, which may be a potential mechanism for the occurrence and development of depression [ 8 ]. Our present findings are consistent with the findings of previous studies, and verifying the correlation between CREB1 and depression in Chinese people [ 7 , 27 ].…”

Section: Discussionsupporting

confidence: 94%

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Correlation between variants of the CREB1 and GRM7 genes and risk of depression

et al. 2023

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The pathogenesis of depression involves cAMP-response element binding protein1 (CREB1) and metabotropic glutamate receptor 7 (GRM7), and their genetic polymorphisms may affect susceptibility to depression. The purpose of this study was to investigate whether the CREB1 polymorphisms rs2253206 and rs10932201 and the GRM7 polymorphism rs162209 are associated with the risk of depression. Using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing, we analyzed the rs2253206, rs10932201, and rs162209 frequencies in 479 patients with depression and 329 normal controls. The results showed that the rs2253206 and rs10932201 polymorphisms were significantly associated with an increased risk of depression. However, no association was found between rs162209 and depression risk. When the data were stratified for several disease-related variables, none of the three polymorphisms were found to be correlated to onset, disease severity, family history, or suicidal tendency. Thus, the present findings indicate that the CREB1 polymorphisms rs2253206 and rs10932201 may be related to the occurrence of depression.

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Section: Discussionsupporting

confidence: 94%

“…Previous work has shown that the rs2253206 and rs10932201 in CREB1 and rs162209 in GRM7 may light on the pathogenesis of depression [ 7 , 26 , 27 ]. However, there are few reports on the genetic susceptibility of CREB1 SNPs rs2253206 and rs10932201 and GRM7 SNPs rs162209 involved in depression.…”

Section: Introductionmentioning

confidence: 99%

Correlation between variants of the CREB1 and GRM7 genes and risk of depression

et al. 2023

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“…SNPs in the CREB1 gene, including rs2253206, have previously been significantly associated with traits linked to cognitive vulnerability. Guo et al (2014) investigated the effect of CREB1 gene polymorphisms on cognitive dysfunction in Chinese patients with major depression and their results suggest the CREB1 gene is a promising marker for cognitive function in major depression patients. Juhasz et al (2011) investigated risk factors for depression, and while studying the neuroplastic pathway, they demonstrated a significant association between the CREB1 rs2253206 polymorphism with rumination and severe depression, reporting that minor allele carriers are less likely to ruminate.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies focusing on depression, schizophrenia, rumination, and negative emotionally related memory impairments have found significant associations with CREB regulation (Kawanishi et al, 1999; Barrot et al, 2002; Lazary et al, 2011; Guo et al, 2014). Genetic polymorphisms can influence the expression of linked loci.…”

Section: Introductionmentioning

confidence: 99%

A CREB1 Gene Polymorphism (rs2253206) Is Associated with Prospective Memory in a Healthy Cohort

Avgan

Sutherland

Lea

et al. 2017

Front. Behav. Neurosci.

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Prospective memory (PM) is generally defined as remembering to perform intended actions in the future and is important for functioning in daily life. Cyclic adenosine monophosphate (cAMP) responsive element binding protein 1 (CREB1) plays an important role in cognitive functions. In this study, we hypothesized that genetic variation in the CREB1 gene is associated with PM. We genotyped a CREB1 promoter polymorphism rs2253206 and tested it for association with PM in 619 healthy subjects. PM performance was measured using the Prospective and Retrospective Memory Questionnaire (PRMQ), the Comprehensive Assessment of Prospective Memory (CAPM), and the Memory for Intentions Screening Test (MIST). Generalized linear model analysis was conducted for each PM test independently using different inheritance models to identify any associations (p < 0.05). After multiple testing adjustments, a significant association was found between the rs2253206 genotype and PM performance for CAPM instrumental activities of daily living measure (p = 0.016). These results suggest that the rs2253206 polymorphism in the CREB1 gene locus is associated with PM in healthy individuals and contributes to knowledge on the genetics of this particular type of memory.

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“…[15][16][17][18] Moreover, cognitive impairment is thought to be an intrinsic characteristic of MDD that may take precedence over depressive symptoms. [19][20][21][22] Despite such extensive studies, the pathological mechanisms of cognitive deficits in MDD remain uncertain.…”

Section: Introductionmentioning

confidence: 99%

<p>Impact of Expression and Genetic Variation of microRNA-34b/c on Cognitive Dysfunction in Patients with Major Depressive Disorder</p>

Sun¹,

Yang²,

He³

et al. 2020

NDT

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Background: Patients suffering from major depressive disorder (MDD) commonly demonstrate lower performance across multiple cognitive domains. Cognitive impairment is an intrinsic characteristic of MDD status and is often influenced by genetic factors. microRNAs (miRNAs or miRs) have been shown to have important implications in the etiology of MDD. Therefore, we aimed to identify and analyze the impact of expression and genetic variation of miR-34b/c on cognitive dysfunction in MDD. Methods: First, we analyzed miR-34c-5p expression in 48 cases of MDD and 54 healthy controls in a Chinese population using qRT-PCR. We assessed the relationship between the level of miR-34c-5p expression and cognitive performance by Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Trail Making Test (TMT). Second, in order to characterize allelic effects of miR-34b/c on cognitive performance in MDD patients, we performed genetic association analysis of single-nucleotide polymorphism (SNP) loci of the MIR34B/C genes with cognitive function in a second group consisting of 531 MDD patients and 267 healthy controls. Results: We found a significant negative correlation between the level of miR-34c-5p expression and both the language and delayed memory index scores in patients with MDD. We also found a significant positive correlation between the level of miR-34c-5p expression and the time required to complete tests A and B of the TMT. The interaction between the rs2187473 genotype and the disease was significant for both immediate memory and delayed memory. In the patient group, the rs2187473 CC genotype was significantly associated with higher performance on immediate memory (F = 6.683, p < 0.05) and delayed memory tasks (F = 4.221, p < 0.05). Conclusion:Our findings suggest that changes in miR-34c expression level have important impacts on cognitive function in patients with MDD. In particular, the polymorphism rs2187473 is a potential genetic risk factor for cognitive function in MDD, which may be of clinical use.

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Preliminary investigation of the influence of CREB1 gene polymorphisms on cognitive dysfunction in Chinese patients with major depression

Cited by 9 publications

References 61 publications

Correlation between variants of the CREB1 and GRM7 genes and risk of depression

Correlation between variants of the CREB1 and GRM7 genes and risk of depression

A CREB1 Gene Polymorphism (rs2253206) Is Associated with Prospective Memory in a Healthy Cohort

<p>Impact of Expression and Genetic Variation of microRNA-34b/c on Cognitive Dysfunction in Patients with Major Depressive Disorder</p>

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