Cigarette smoke is probably the most significant source of Background: exposure to toxic chemicals for humans, involving health-damaging components, such as nicotine, hydrogen cyanide and formaldehyde. The aim of the present study was to assess the influence of chronic heavy smoking on color discrimination (CD).All subjects were free of any Methods: neuropsychiatric disorder, identifiable ocular disease and had normal acuity. No abnormalities were detected in the fundoscopic examination and in the optical coherence tomography exam. We assessed color vision for healthy heavy smokers ( = 15; age range, 20-45 years), deprived smokers ( = 15, n n age range 20-45 years) and healthy non-smokers ( = 15; age range, 20-45 n years), using the psychophysical forced-choice method. All groups were matched for gender and education level. In this paradigm, the volunteers had to choose the pseudoisochromatic stimulus containing a test frequency at four directions (e.g., up, down, right and left) in the subtest of Cambridge Colour Test (CCT): Trivector.Performance on CCT differed between groups, Results: and the observed pattern was that smokers had lower discrimination compared to non-smokers. In addition, deprived smokers presented lower discrimination to smokers and non-smokers. Contrary to expectation, the largest differences were observed for medium and long wavelengths.These results
Conclusions:suggests that cigarette smoke and chronic exposure to nicotine, or withdrawal from nicotine, affects CD. This highlights the importance of understanding the diffuse effects of nicotine either attentional bias on color vision.
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