Preliminary observations of anaesthesia ventilators use for prolonged mechanical ventilation in intensive care unit patients during the COVID-19 pandemic

Gouel-Cheron, Aurélie; Couffignal, Camille; Elmaleh, Yoann; Kantor, Elie; Montravers, Philippe

doi:10.1016/j.accpm.2020.04.009

Cited by 10 publications

(10 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To the best of our knowledge, this is the first study reporting characteristics of and outcomes from COVID-19 for patients requiring ICU admission in Egypt. Similar to previous studies from European [ 2 , 3 , 5 , 8 , 10 , 12 , [15] , [16] , [17] , [18] , 21 , 31 , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] ], North American [ 4 , 6 , 7 , [24] , [25] , [26] ], and Asian [ 11 , 19 , 20 , 23 , [27] , [28] , [29] , [30] , 44 ] ICUs, more than two-thirds of our patients were male, with a high prevalence of preexisting comorbid conditions. Nonetheless, 23% of patients in our cohort did not have known comorbid conditions, suggesting that severe SARS-Cov-2 infections with a fatal outcome may also occur in otherwise healthy individuals.…”

Section: Discussionsupporting

confidence: 91%

Outcomes and risk factors for death in patients with coronavirus disease-2019 (COVID-19) pneumonia admitted to the intensive care units of an Egyptian University Hospital. A retrospective cohort study

Nassar

Mokhtar

Elhadidy

et al. 2021

Journal of Infection and Public Health

View full text Add to dashboard Cite

Background The characteristics, outcomes, and risk factors for in-hospital death of critically ill intensive care unit (ICU) patients with coronavirus disease-2019 (COVID-19) have been described in patients from Europe, North America and China, but there are few data from COVID-19 patients in Middle Eastern countries. The aim of this study was to investigate the characteristics, outcomes, and risk factors for in-hospital death of critically ill patients with COVID-19 pneumonia admitted to the ICUs of a University Hospital in Egypt. Methods Retrospective analysis of patients with COVID-19 pneumonia admitted between April 28 and July 29, 2020 to two ICUs dedicated to the isolation and treatment of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in Cairo University Hospitals. Diagnosis was confirmed in all patients using real-time reverse transcription polymerase chain reaction on respiratory samples and radiologic evidence of pneumonia. Results Of the 177 patients admitted to the ICUs during the study period, 160 patients had COVID-19 pneumonia and were included in the analysis (mean age: 60 ± 14 years, 67.5% males); 23% of patients had no known comorbidities. The overall ICU and hospital mortality rates were both 24.4%. The ICU and hospital lengths of stay were 7 (25–75% interquartile range: 4–10) and 10 (25–75% interquartile range: 7–14) days, respectively. In a multivariable analysis with in-hospital death as the dependent variable, ischemic heart disease, history of smoking, and secondary bacterial pneumonia were independently associated with a higher risk of in-hospital death, whereas greater PaO 2 /FiO 2 ratio on admission to the ICU was associated with a lower risk. Conclusion In this cohort of critically ill patients with COVID-19 pneumonia, ischemic heart disease, history of smoking, and secondary bacterial pneumonia were independently associated with a higher risk of in-hospital death.

show abstract

Section: Discussionsupporting

confidence: 91%

Outcomes and risk factors for death in patients with coronavirus disease-2019 (COVID-19) pneumonia admitted to the intensive care units of an Egyptian University Hospital. A retrospective cohort study

Nassar

Mokhtar

Elhadidy

et al. 2021

Journal of Infection and Public Health

View full text Add to dashboard Cite

show abstract

“…Anesthesia machines are being repurposed as critical care ventilators during the COVID-19 pandemic. 18,[24][25][26]28,29 Their use should be overseen by an anesthesia provider; however, respiratory therapists will be involved in their monitoring and use. Anesthesia machines are fundamentally different than critical care ventilators, and respiratory therapists should be familiar with these differences.…”

Section: Discussionmentioning

confidence: 99%

Using Anesthesia Machines as Critical Care Ventilators During the COVID-19 Pandemic

Austin

Branson

2021

Respir Care

View full text Add to dashboard Cite

Somewhere between 30% and 89% of patients with COVID-19 admitted to a critical care unit require invasive mechanical ventilation. Concern over the lack of adequate numbers of critical care ventilators to meet this demand led the U.S. Food and Drug Administration to authorize the use of anesthesia machines as critical care ventilators. The use of anesthesia machines for ventilating patients with COVID-19 is overseen by an anesthesia provider, but respiratory therapists may encounter their use. This article reviews the fundamental differences between anesthesia machines and critical care ventilators, as well as some common problems encountered when using an anesthesia machine to ventilate a patient with COVID-19 and steps to mitigate these problems.

show abstract

“…Whereas the SARS epidemic in 2003 was effectively brought under control in eight months, the number of new cases and new deaths caused by COVID-19 have continued to soar with over 2.8 million new cases and 39,712 new deaths reported in the week ending on 25 October 2020 [ 7 ]. The health care system of a nation can be stretched to capacity and even overwhelmed when there is a rapid rise in COVID-19 cases due to the need for dedicated wards, medical personnel, and substantial use of limited ICU resources [ 8 ]. This makes the availability of accurate diagnostic tools for the timely detection of SARS-CoV-2 extremely important so that the isolation of cases, delivery of appropriate patient care and tracing of close contacts can be executed in parallel with the implementation of other non-pharmacological preventive measures to suppress and mitigate the spread of this disease [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Nucleic Acid-Based Diagnostic Tests for the Detection SARS-CoV-2: An Update

Chan

Yean

et al. 2021

Diagnostics

View full text Add to dashboard Cite

The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began as a cluster of pneumonia cases in Wuhan, China before spreading to over 200 countries and territories on six continents in less than six months. Despite rigorous global containment and quarantine efforts to limit the transmission of the virus, COVID-19 cases and deaths have continued to increase, leaving devastating impacts on the lives of many with far-reaching effects on the global society, economy and healthcare system. With over 43 million cases and 1.1 million deaths recorded worldwide, accurate and rapid diagnosis continues to be a cornerstone of pandemic control. In this review, we aim to present an objective overview of the latest nucleic acid-based diagnostic tests for the detection of SARS-CoV-2 that have been authorized by the Food and Drug Administration (FDA) under emergency use authorization (EUA) as of 31 October 2020. We systematically summarize and compare the principles, technologies, protocols and performance characteristics of amplification- and sequencing-based tests that have become alternatives to the CDC 2019-nCoV Real-Time RT-PCR Diagnostic Panel. We highlight the notable features of the tests including authorized settings, along with the advantages and disadvantages of the tests. We conclude with a brief discussion on the current challenges and future perspectives of COVID-19 diagnostics.

show abstract

Preliminary observations of anaesthesia ventilators use for prolonged mechanical ventilation in intensive care unit patients during the COVID-19 pandemic

Cited by 10 publications

References 2 publications

Outcomes and risk factors for death in patients with coronavirus disease-2019 (COVID-19) pneumonia admitted to the intensive care units of an Egyptian University Hospital. A retrospective cohort study

Outcomes and risk factors for death in patients with coronavirus disease-2019 (COVID-19) pneumonia admitted to the intensive care units of an Egyptian University Hospital. A retrospective cohort study

Using Anesthesia Machines as Critical Care Ventilators During the COVID-19 Pandemic

Nucleic Acid-Based Diagnostic Tests for the Detection SARS-CoV-2: An Update

Contact Info

Product

Resources

About