Preliminary observations of serum carbamazepine concentration in epileptic patients

Effect of single- and multiple-dose carbamazepine on the pharmacokinetics of diphenylhydantoin

“…Pretreatment for 1 week with CBZ 200 mg t. d. s. decreased the AUC, of phenytoin by 43 %. The results are in accordance with those of several clinical studies [6][7][8][9].…”

“…In contrast, reports of the effect of CBZ on the disposition of phenytoin are controversial. While some authors have reported that CBZ induced a fall in the plasma phenytoin level [6][7][8][9], others found that the serum phenytoin level was elevated during co-medication with CBZ [10-131. There are several possible explanations for the controversy; phenytoin is highly bound to serum proteins, and CBZ may displace phenytoin from the binding sites; CBZ may also inhibit phenytoin metabolism, or, as is well known as an enzyme inducer after chronic use, phenytoin metabolism may be induced by CBZ co-administered. It is also possible that the absorption of phenytoin may somehow be affected by CBZ.…”

Carbamazepine: An Attempt to Correlate Serum Levels with Anti-Epileptic and Side Effects

“…Blood was drawn from 75 institutionalized and 94 patients from the hospital for seizure disorders "Mara I" under chronic carbamazepine medication, once in the morning fasting and a second time 3 hrs after the morning medication at the (nearby) peak serum level (see Cereghino et al, 1973). Eight of these patients received carbamazepine as the only medication; in the others a multi-drug regimen including phenytoin, phenobarbitone, barbexaclone (propylhexedrine-phenobarbitone, Maliasin®), primidone, succinimides or various other drugs was present.…”

Evaluation of albutoin as an antiepileptic drug

“…Daily ward sheets 4 were maintained by specially trained ward clerks and mailed to the Section on Epilepsy, National Institute of Neurological Diseases and Stroke, for data verification and tabulation.…”