Preliminary Pharmacokinetics of Streptozotocin, an Antineoplastic Antibiotic

Adolphe, Allen B; Glasofer, E.D.; Troetel, W. M.; Weiss, Arthur J.; Manthei, R. W.

doi:10.1002/j.1552-4604.1977.tb04620.x

Cited by 20 publications

(10 citation statements)

References 11 publications

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“…Although possible confounding effects of STZ cannot be excluded, the half-life of the drug is ∼15 minutes, and it is cleared from the organs within 4 hours [54]. Since the present study was conducted at such a late period after STZ treatment (8 weeks post-STZ injection), the results reported herein are likely related to the development of diabetes.…”

Section: Discussionmentioning

confidence: 91%

Alterations in the diabetic myocardial proteome coupled with increased myocardial oxidative stress underlies diabetic cardiomyopathy

Hamblin

Friedman

Hill

et al. 2007

Journal of Molecular and Cellular Cardiology

113

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Section: Discussionmentioning

confidence: 91%

Alterations in the diabetic myocardial proteome coupled with increased myocardial oxidative stress underlies diabetic cardiomyopathy

Hamblin

Friedman

Hill

et al. 2007

Journal of Molecular and Cellular Cardiology

113

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“…Although possible confounding effects of STZ cannot be excluded, the half-life of the drug is 15 minutes, and it is cleared from the organs within 4 hours (65). Since the present study was conducted at such a late period after STZ treatment (8 weeks post-STZ injection), the results reported herein are likely related to the development of diabetes.…”

Section: Discussionmentioning

confidence: 91%

Dietary Supplementation With Vitamin E Ameliorates Cardiac Failure in Type I Diabetic Cardiomyopathy by Suppressing Myocardial Generation of 8-iso-Prostaglandin F2α and Oxidized Glutathione

Hamblin

Smith

Hill

2007

Journal of Cardiac Failure

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Background-Diabetic cardiomyopathy has been documented as an underlying etiology of heart failure (HF) in diabetic patients. Although oxidative stress has been implicated in diabetic cardiomyopathy, much of the current evidence lacks specificity. Furthermore, studies investigating antioxidant protection with vitamin E in this unique cardiac phenomenon have yet to be performed. In the present study, we sought to determine whether vitamin E supplementation can confer cardioprotective effects against diabetic cardiomyopathy in relation to specific and quantitative markers of myocardial oxidative stress.

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“…Several studies have suggested that the compound is capable of causing direct renal injury, particularly to the proximal renal tubule [3,6.7]. Strepto zotocin accumulates in the liver and kidney tissue, and exhibits a half-life in these tissues which is significantly longer than its half-life in plasma [8,10,11]. In this way streptozo tocin resembles the aminoglycosides, a group of potentially nephrotoxic antibiotics [12].…”

Section: Discussionmentioning

confidence: 99%

“…Occluding the hilum of one kidney for 5 min during and following strcptozotocin administration, prolonged the half-life to 11.7 min reaffirming the fact that streptozotocin is rapidly removed by the kidney [11]. We chose to examine the AUC in protected and nonprotected kidneys in order to have a potentially more sensitive indicator of tissue kinetics than would be provided by either tissue concentrations or tissue half-life alone.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Streptozotocin and Streptozotocin-Induced Diabetes on the Kidney

Evan¹,

Mong²,

Gattone³

et al. 1984

Kidney Blood Press Res

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The study of diabetic nephropathy in experimental animals generally relies on the chemical induction of the diabetic state. Streptozotocin is commonly employed to that end; however, streptozotocin has an inherent nephrotoxic potential. We studied the effects of both streptozotocin, and diabetes on the kidneys of rats given streptozotocin 60 mg/kg, which was sufficient to induce severe diabetes. Our studies, which utilized both transmission and scanning electron microscopy, considered the pharmacokinetics of streptozotocin in renal tissue, as well as the effect of insulin treatment. Renal tissue kinetics were altered by occluding the renal hilum of one kidney during, and for 5 min after, the administration of streptozotocin. We found that, in contrast to alloxan, streptozotocin caused no detectable renal injury at the dose employed. Previously described renal epithelial papillomas were identified, and were not influenced by altering the renal tissue kinetics of the drug. We conclude that no ‘protection’ procedure is necessary for the kidney when the streptozotocin model of diabetes is employed. In this regard streptozotocin may have greater utility than alloxan.

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Preliminary Pharmacokinetics of Streptozotocin, an Antineoplastic Antibiotic

Cited by 20 publications

References 11 publications

Alterations in the diabetic myocardial proteome coupled with increased myocardial oxidative stress underlies diabetic cardiomyopathy

Alterations in the diabetic myocardial proteome coupled with increased myocardial oxidative stress underlies diabetic cardiomyopathy

Dietary Supplementation With Vitamin E Ameliorates Cardiac Failure in Type I Diabetic Cardiomyopathy by Suppressing Myocardial Generation of 8-iso-Prostaglandin F2α and Oxidized Glutathione

The Effect of Streptozotocin and Streptozotocin-Induced Diabetes on the Kidney

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