Preliminary Phytochemical Investigation and <i>In Vitro</i> Anti Bacterial Studies of <i>Polycarpaea aurea</i> Wight and Arn (Caryophyllaceae) Emulgel

D, Jamal Basha; Br, Srinivas Murthy; Prakash, Prem; Kc, Anuradha

doi:10.5958/2231-5691.2018.00027.8

Cited by 9 publications

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“…The polyherbal emulgel formulation showed significant anti-inflammatory activity in the presence of cow ghee as permeation enhancer and this activity was better than that of commercial diclofenac gel (Shrikhande, 2013) Lantana camara/Leaves Carbopol 934, Na CMC, HPMC, HPMC K15M, and HEC Formulations prepared with Na CMC showed optimal physicochemical properties and significant improvement in wound contraction (Sultana et al, 2016) Combination of Curcuma longa and Tinospora cordifolia/Rhizome, leaves respectively Carbopol 940 Optimized emulgel formulation produced sustained anti-arthritic activity for up to 18 h (Thakur et al, 2016) Cardiospermum halicacabum/Leaves Na CMC Emulgel formulation demonstrated appreciable diffusion through animal skin and its anti-arthritic activity was comparable to that of commercially available diclofenac gel (Suganya et al, 2017) Strawberry/Fruit Carbopol 940 Formulation decreased skin melanin, improved skin hydration, and promoted skin whitening in healthy female human participants (Kausar and Akhtar, 2017) Terminalia arjuna/Bark Carbopol 934 Emulgel formulation for topical delivery of the extract was found be stable and possessed good release profile (Gaikwad and Jadhav, 2018) Combination of Ocimum tenuiflorum and Mentha arvensis/Both leaves Na CMC The formulation exhibited significant and accelerated activity against acne (Susmitha and Devi, 2018) Polycarpaea aurea/Whole plant Carbopol 934 Formulation showed greater broad spectrum activity against the formulation of Ofloxacin (Jamal et al, 2018) Coriandrum sativum/Seeds Carbopol 940 Emulgel of the seed oil showed significant antiinflammatory activity (Mohite and Salunkhe, 2019) Coccinia grandis/Leaves Carbopol 940, Carbopol 934 Formulation prepared with Carbopol 934 and liquid paraffin exhibited good antibacterial activity (Guntupalli et al, 2019) Zingiber officinale/Roots Na CMC Formulation prepared with 1.5 % Na CMC showed highest release, better stability and significant inhibition of bacteria growth than formulations with less concentration of Na CMC (Desai and Mhaskar , 2019) Combination of Phyllanthus emblica, Centella asiatica, Wedelia calendulacea, Cucurbita pepo/Fresh fruits, both leaves, seeds respectively Carbopol 934…”

Section: Carbopol 940mentioning

confidence: 99%

Emulgel: A Promising Technology for Topical Delivery of Herbal Extracts

Olayemi

David

2023

British Journal of Pharmacy

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Topicaldrug delivery is a remarkable but arduous task due to the inherent barriersystem of the skin. More so, only a narrow range of drugs are available fortopical use because most drugs are hydrophobic in nature and this restrictstheir permeation and absorption into the skin. Herbal remedies have been usedin the treatment of various diseases including skin diseases for centuries and aregradually becoming acceptable as treatment options however, they are mostlyhydrophobic. Growing interests in combating these issues have led formulatingscientists to develop drug delivery systems like emulgels which are goodcarriers of hydrophobic drug molecules. Emulgels are a mixture of an emulsion anda gel, where drugs are incorporated into globules and solubilized, enhancingdrug absorption from the skin. They are easily spread over the skin, easilyremoved from the skin, possess emollient properties, are non-greasy, cosmeticallyappealing and have good penetrating abilities. This review highlights theimportance of emulgels in the delivery of herbal extracts/constituents, the methodsof formulations and an overview of herbal emulgel formulations that have beenexploited by different researchers. Emulgels have proven to be good prospectsin enhancing the topical delivery of herbals and improving the treatment of skininfections. 

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Section: Carbopol 940mentioning

confidence: 99%

Emulgel: A Promising Technology for Topical Delivery of Herbal Extracts

Olayemi

David

2023

British Journal of Pharmacy

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Effect of combination of some Polymers with Carbopol 940 on Pregabalin Release Rate from Emulgels

Haddad

Hasian

2022

RJPT

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Topical Emulgels of Pregabalin were formulated using Carbopol 940 in combination with (PVP k90, PEG 200, PEG 1000, HPMC K15M) to obtain the optimal formula in terms of drug release rate. Physical appearance, pH, viscosity, stability, drug content, In-vitro drug release, Differential scanning calorimetry and Fourier transform infrared spectroscopy, were tested in all formulas and evaluated to determine the best one. All formulations had good physical properties and stability, F2 which contains Carbopol 940 0.4% and HPMC K15M 0.4% gave the best drug release rate: (30% in 20 min and 93% in 360 min). But F3 which contains Carbopol 940 0.4% and PEG 200 10% showed the less release rate at 360 min: (64%). F2 showed Korsmeyer–Peppas model Kinetic release. So F2 was the best formula because it released drug since 10 min and still to 360 min (6 hours), thus F2 can be used to obtain rapid analgesic effect and avoid CNS-mediated side effects of Pregabalin.

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Antifungal activity of Terminalia chebula extract against wilt fungi Fusarium oxysporum an important plant pathogen

S.B

2023

RJPT

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Terminalia chebula, a deciduous plant, endogenous to India has medicinal value. Its fruits are known for its cure to many ailments in human beings. This study is to test the biological activity of these compounds tested against plant pathogenic fungi Fusarium oxysporum which cause wilt in economically important crops. Wilt is a devastating disease which destroys the infected plant and cause economic loss to farmers. Panama disease in bananas is a type of wilt disease which is very prevalent in India. This fungi has broad host range from tomato, cotton etc. Outbreak reported in many parts of India. Standard culture of Fusarium oxysporum ITCC -6246, Fusarium oxysporum f. sp. ciceri ITCC 3636 and Fusarium oxysporum f. sp. lycopersici MTCC 10270 were used to detect the potential chemical compound in dried fruit by macro-dilution. Each organic solvent (Water, Ethanol, Chloroform, Benzene) has different extraction capacity based on the polarity of chemical compound in plants. These chemical compounds extensively studied for their antioxidant property and preliminary screening of chemical compound constituents in all extract. Mycelium growth inhibition tested on solid medium and zone of inhibition measured in mm diameter. Spores of Fusarium sp. present in soil for many months in dormant form. Under suitable climatic conditions this will germinate and cause infection in plants. Rate of spore germination inhibition in liquid medium measured and calculated for every solvent extract. Rate of inhibition was calculated and analysed statistically by t test. The efficient solvent extract determined for bulk extraction of biologically active compound from seeds.

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Preliminary Phytochemical Investigation and In Vitro Anti Bacterial Studies of Polycarpaea aurea Wight and Arn (Caryophyllaceae) Emulgel

Cited by 9 publications

References 0 publications

Emulgel: A Promising Technology for Topical Delivery of Herbal Extracts

Emulgel: A Promising Technology for Topical Delivery of Herbal Extracts

Effect of combination of some Polymers with Carbopol 940 on Pregabalin Release Rate from Emulgels

Antifungal activity of Terminalia chebula extract against wilt fungi Fusarium oxysporum an important plant pathogen

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