Preliminary Phytochemical Screening and in Vitro Antioxidant Activity of Ethiopian Indigenous Medicinal Plants, Ocimum Lamiifolium Hochst. Ex Benth and Ocimum Basilicum L.

Nair, Suresh Kumar P.; Ganesan, Kumar; Azalewor, Henok Gulilat; Letha, Neethu; Gani, Sharmila Banu

doi:10.25004/ijpsdr.2016.080105

Cited by 10 publications

(9 citation statements)

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“…Anti-inflammatory agents like non-steroidal anti-inflammatory drugs (NSAIDs) prevent diarrhea through inhibition of prostaglandin synthesis. Similarly, the leaf extract of O. lamiifolium showed antioxidant activity [ 29 ]. Therefore, antidiarrheal activity of the extract of the leaf might be through inhibition of prostaglandin synthesis.…”

Section: Discussionmentioning

confidence: 99%

“…It is also used for the treatment of cold, measles, eye infections [ 21 ], and used as mosquito repellent [ 16 , 22 ]. Additionally, in vivo and in vitro studies with positive results were obtained for antimalarial, insecticidal, analgesic, anti-inflammatory, hepatoprotective, antipyretic, and antioxidant activities [ 23 – 29 ]. Furthermore, the methanol extract of the leaf of the plant was safe at 2000 mg/kg in Swiss albino mice [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…The presence of chemical compounds including alkaloids, sterols, carbohydrates, glycosides, tannins, flavonoids, bornyl acetate, p -cymene, camphene, a -pinene, and sabinene was also reported from the essential oil analysis of O. lamiifolium [ 29 – 32 ]. These chemical components have antimicrobial, antibacterial, and antifungal properties [ 16 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Antidiarrheal Effect of 80% Methanol Extract and Fractions of the Leaves of Ocimum lamiifolium in Swiss Albino Mice

Alemu

Andargie

Sisay

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Introduction. Worldwide, in children of under five years of age, diarrhea is responsible for more than 760,000 annual deaths. It is treated with both modern drugs and traditional medicinal plants, including O. lamiifolium. But the use of this plant as an antidiarrheal agent is not scientifically validated. Therefore, this study was aimed to evaluate antidiarrheal efficacy of the plant. Method. The leaf powder was macerated by 80% methanol and then fractionated using n-hexane, n-butanol, and distilled water. Antidiarrheal activity was evaluated through different models (castor oil-induced diarrhea, enteropooling, and motility) using onset, number of wet feces, fluid content, weight and volume of intestinal content, and motility as test parameters by administering treatment doses to groups of mice. Group I received 10 mL/kg of the dissolving vehicle, Group II received either loperamide or atropine, and Groups III-V received extract doses of 100, 200, and 400 mg/kg, respectively. One-way ANOVA was used to analyze the data, followed by Tukey’s post-hoc test. Results. The crude extract exhibited a significant effect on the fluid content of feces at all tested doses. Additionally, the n-butanol and distilled water fractions revealed significant effects on onset of diarrhea at 400 mg/kg ( p < 0.05 ), while the n-hexane fraction showed significant effects on number of wet feces, onset, and fluid content of feces at all tried doses. The crude extract and all the fractions (at 200 and 400 mg/kg) decreased the weight and volume of intestinal content significantly. Similarly, both the crude extract and distilled water fraction at 400 mg/kg as well as n-butanol and n-hexane fractions at 200 and 400 mg/kg showed meaningful differences on peristaltic index as compared to the negative control. Conclusion. The results revealed that the leaf extract of O. lamiifolium has an antidiarrheal activity, which supports the traditional medical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antidiarrheal Effect of 80% Methanol Extract and Fractions of the Leaves of Ocimum lamiifolium in Swiss Albino Mice

Alemu

Andargie

Sisay

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…The hydromethanolic extract of T. brownii was qualitatively screened for the presence or absence of bioactive phytochemicals such as alkaloids, polyphenols, flavonoids, tannins, saponins, terpenoids, and steroids. 37…”

Section: Preliminary Phytochemical Screeningmentioning

confidence: 99%

<p>Antidiabetic Activity of Extracts of <em>Terminalia brownii</em> Fresen. Stem Bark in Mice</p>

Alema¹,

Periasamy²,

Sibhat³

et al. 2020

JEP

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Background: Diabetes mellitus is a chronic metabolic disorder that imposes a huge health and economic burden on societies. Because the currently available medications have many drawbacks, it is important to search for alternative therapies. Medicinal plants used in traditional medicines are ideal candidates. Hence, this study was undertaken to investigate the antidiabetic activity of crude extract and solvent fractions from the stem bark of Terminalia brownii Fresen. (Combretaceae) in mice. Materials and Methods: The in vitro α-amylase inhibition assay was performed using the chromogenic 3, 5-dinitrosalicylic acid (DNSA) method while the antihyperglycemic activity was assessed using three mouse models: streptozotocin-induced diabetic mice, normoglycemic mice, and oral glucose challenged mice. Experimental diabetes was induced by a single intraperitoneal injection of streptozotocin at a dose of 150 mg/kg and animals with fasting blood glucose level (BGL) >200 mg/dL were considered diabetic. Glibenclamide (5 mg/kg) was used as a standard drug. Fasting BGL and body weight were used to assess the antidiabetic activity. The result was analyzed using GraphPad Prism software version 8 and one-way ANOVA followed by Tukey's post hoc test with p<0.05 considered as statistically significant. Results: The crude extract of T. brownii at all tested dose levels (250, 500 and 750 mg/kg) showed a significant BGL reduction in all the three animal models. Moreover, the ethyl acetate and aqueous fractions (at 500 mg/kg) significantly (p<0.01) reduced the BGL in the streptozotocin induced diabetic model. The crude extract and different solvent fractions also showed a dose-dependent in vitro α-amylase inhibitory activity and improvement of body weight. Conclusion: T. brownii crude extract and its solvent fractions showed a significant antihyperglycemic activity in STZ induced diabetic mice, hypoglycemic activity and improvement of oral glucose tolerance in normal mice.

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“…Dietary phytochemicals are constituents of natural foods and dietary supplements that serve both basic human nutritional needs and provide changes in health status (Ganesan & Xu, 2017c, 2018b). These compounds are abundant in plants, and many have been used as primordial traditional medicines, including polyphenols, terpenoids, alkaloids, and phenolics (Mickymaray & Alturaiki, 2018; Mickymaray et al., 2016; Nair et al., 2016; Pandian et al., 2006; Sukalingam et al., 2017). The dietary phytochemicals most often presented to be effective against numerous diseases include apigenin (parsley), baicalein (Indian trumpet), curcumin (turmeric), diallyl sulfide (onion), ellagic acid (pomegranate), epigallocatechin‐3‐gallate (EGCG) (green tea), genistein (soybean), gingerol (ginger), isothiocyanates (cruciferous vegetables), lycopene (tomatoes), quercetin (leafy vegetables, broccoli), resveratrol (grapes), rosmarinic acid (rosemary), silymarin (milk thistle), sulforaphane (cruciferous vegetables), and catechins (green tea).…”

Section: Dietary Phytochemicalsmentioning

confidence: 99%

Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases

et al. 2021

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The intestinal epithelium acts as a key defensive barrier that protects internal organs from the detrimental gut environment. The homeostasis of the gut epithelium may be altered by environmental conditions and exogenous pathogens that can impair the integrity of the gut barrier, leading to immune response associated with low‐grade systemic inflammation, a known contributor to metabolic and inflammatory diseases. Autoimmune diseases (ADs) are a collection of abnormalities of the immune system, in which the immune system of an individual acts against healthy organs or systems, due to a failure in antigenic recognition. Hence, this review aims to focus on modulators of intestinal epithelial barrier dysfunction with effects on autoimmune disorders. All data on dietary phytochemicals and their impact on the modulation of the intestinal epithelium barrier and various ADs were collected from electronic searches of library databases (PubMed, Science Direct, and Google Scholar). An electronic search was conducted using PubMed, Science Direct, and Google Scholar by finding the keywords “phytochemicals” AND “bioactive compounds” AND “flavonoids” AND “polyphenols” OR “intestinal epithelium barrier” OR “autoimmune diseases” OR “inflammatory diseases” in “Title/Abstract/Keywords,” with the date from January 2011 to December 2020, to identify all published studies (in vitro, in vivo, clinical, and case‐control) that have investigated the connection between dietary phytochemicals and their various beneficial effects. Dietary phytochemicals are promising key modulators, stabilizing the integrity of the intestinal barrier and attenuating the progression of ADs. Health‐modulatory information was gathered and orchestrated in a suitable place in this review.

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Preliminary Phytochemical Screening and in Vitro Antioxidant Activity of Ethiopian Indigenous Medicinal Plants, Ocimum Lamiifolium Hochst. Ex Benth and Ocimum Basilicum L.

Cited by 10 publications

References 0 publications

Antidiarrheal Effect of 80% Methanol Extract and Fractions of the Leaves of Ocimum lamiifolium in Swiss Albino Mice

Antidiarrheal Effect of 80% Methanol Extract and Fractions of the Leaves of Ocimum lamiifolium in Swiss Albino Mice

<p>Antidiabetic Activity of Extracts of <em>Terminalia brownii</em> Fresen. Stem Bark in Mice</p>

Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases

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