Preliminary Report on the Origin of Rat Mast Cells

Thiede, A; Hk, Müller-Hermelink; Hg, Sonntag; Müller-Ruchholtz, W; Ld, Leder

doi:10.1007/bf01485001

Cited by 13 publications

(5 citation statements)

References 7 publications

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“…It has recently been shown that mast cells can develop from blood-borne precursors derived from hemopoietic pluripotential stem cells (Kitamura et al, 1981). Differentiation of mature mast cells from precur-sor cells that have become recognizable through the acquisition of some characteristic granules has been reported to take 7 days in the fetal rat (Combs et al, 1965) and 5 days in the adult rat (Thiede et al, 1971). Fawcett (1955) reported that new mast cells were found in the vicinity of blood vessels 8-12 days after the disruption of peritoneal mast cells in the adult rat.…”

Section: Discussionmentioning

confidence: 99%

Changes in uterine mast cells during the estrous cycle in the Syrian hamster

Brandon

Evans

1983

Am. J. Anat.

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Adult virgin female Syrian hamsters were killed at known stages of the estrous cycle, and mast cells were counted in the myometrium, endometrium, and mesometrial-triangle region of the uterus and in the pinna. Tissues were fixed in Helly's solution, and mast cells were stained using 0.06% toluidine blue in 0.12 M Michaelis' veronal acetate-hydrochloric acid buffer, pH 4.5. The number of mast cells in the myometrium and endometrium was found to vary with the estrous cycle, whereas the number in the mesometrial-triangle region and the pinna showed no such variation. The number of mast cells in the myometrium and endometrium was lowest on day 4 of the cycle (the day before the night during which ovulation would occur) and increased approximately twofold to maximal levels found on days 1 and 2. Intermediate levels were seen on day 3. The origin of the increase in mast cell numbers from day 4 to day 1 was investigated using a combined alcian blue--safranin stain to differentiate between immature and mature mast-cell granules. The results obtained did not support the hypothesis that the increase was due to de novo differentiation of mast cells from precursors, but, equally, no evidence was obtained to refute this hypothesis.

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Section: Discussionmentioning

confidence: 99%

Changes in uterine mast cells during the estrous cycle in the Syrian hamster

Brandon

Evans

1983

Am. J. Anat.

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“…A mesenchymal origin was also suggested by Burton [1963] in the case of the stem cell of skin MCs. More specifically, Csaba et al [1970], observ ing MC development in mouse spleen and thymus, thought that the mesenchymal cell is lymphoid, where as, Desaga et al [1971] and Thiede et al [1971] believed that it was a monocytic cell from which rat peritoneal MCs regenerated after damage. Regarding the perivas cular MCs of the CNS, only one study has suggested a source for these cells, namely the mesenchymally de rived pericyte [Flood and Kruger, 1970], The present findings cannot confirm this however since pericytes, being nongranular cells, did not resemble maturing MCs.…”

Section: Discussionmentioning

confidence: 99%

“…Also, because of this peculiar glycogen content, as well as characteristic morphology, it seems rather unlikely that the leptomeningeal cells could bear any direct ancestral relationship to any of the cellular elements of this study. Furthermore, it has been shown that leptomeningeal cells arise from neural crest material [Langman, 1975], whereas MCs and macro phages are connective tissue cells of mesenchymal origin [Csaba et al, 1970;Desaga et al, 1971;Thiede et al, 1971;Oehmichen, 1973;Ling, 1978]; pigment cells, if related to melanocytes, would be of neural crest origin as well.…”

Section: Discussionmentioning

confidence: 99%

The Mast Cells of the Mammalian Central Nervous System

Ibrahim¹

1985

Cells Tissues Organs

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There are four potentially granular or frankly granular cells within the connective tissue compartment of the mammalian central nervous system, whether this is part of the surface leptomeninges or the leptomeningeal sleeves around parenchymal blood vessels larger than capillaries. These are: (1) Cells that behave like macrophages, part of the mononuclear phagocyte system of the body; they are granular to varying degrees (containing lysosomes). (2) Brown-pigmented granular cells which are mainly located on the surface but are also seen for varying distances along blood vessels as they pass inside the CNS of pigmented animals. (3) Mast cells (MCs) which are granular and located especially prominently in surface leptomeninges of young mammals, and, in adults, are restricted to special parts of the CNS. (4) Granular cells, referred to by me as neurolipomastocytoid cells (NLMs), are numerous, ubiquitously distributed, and seem to have morphological features in common with those of both MCs and macrophages. The exact identiy of these NLMs still needs to established. One approach was to study the development of all three non – pigmented cells in the immature brain of the albino rat, especially at the ultrastructural level. This communication represents the findings regarding the MCs. The MCs appear to arise from a small mononuclear cell and to go through maturation stages identical to those described by others for MCs outside the CNS. The greatly flattened adjacent leptomeningeal cells are an easily identifiable entity especially’due to their peculiar glycogen content in the young.

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“…Ginsburg [26] stated that "one cannot ignore the possibility that the cells of the body known as mast cells may form a heterogeneous collection of cells, which have nothing more in common than that they contain materials that have the property of staining metachromatically." Thied et al [100] produced evidence of the immunologic identity of rat thymus mast cells and macrophages. Csaba and Hodinka [13] concluded that rat mast cells developed in the thymus from T-lymphocytes and reached full development in the peritoneal cavity.…”

Section: Mast Cellsmentioning

confidence: 99%

Endogenous Heparin

Jaques¹

2008

Semin Thromb Hemost

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Since the drug, heparin, is prepared from mammalian tissue, there is a widespread assumption that its presence in tissue (as endogenous heparin) normally plays an important role in the prevention of coagulation and thrombosis [24,101] This assumption in turn is based on the further assumptions that significant amounts of heparin are present normally in primate tissue and that mast cells and heparin are synonymous. Such conclusions are derived from evidence that defines heparin as an anticoagulant, a releaser of lipoprotein lipase, a metachromatic mucopolysaccharide, or as the metachromatic component of mast cells and basophilic leukocytes. DEFINITIONS USED FOR HEPARIN IN BLOOD OR TISSUESListed below are operational definitions for endogenous heparin which are widely used. Other substances satisfying each definition are given in parentheses.(1) Anticoagulant activity which (a) appears in plasma (fibrinogen split products, antibodies to coagulation factors, etc); (b) is heat stable (inorganic salts, organic acids, amino acids and polyaminoacids, lipid inhibitors, other mucopolysaccharides); (c) occurs in tissues (lipids, other mucopolysaccharides, peptones, peptides, inorganic salts); (d) inhibited by protamine or toluidine blue (fibrinogen, fibrin split products, nucleic acids, chondroitins [sulfate] A,B,C,D & E,heparitins [sulfate] A,B,C,D).(2) Activity in releasing lipoprotein lipase, etc., which is blocked by protamine, etc. (other sulfated mucopolysaccharides).(3) Mucopolysaccharide characterized by (a)carbazole color reaction (chondroitins, heparitins, uronic acids [detoxication products]); (b)not eluted from adsorbents by

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Preliminary Report on the Origin of Rat Mast Cells

Cited by 13 publications

References 7 publications

Changes in uterine mast cells during the estrous cycle in the Syrian hamster

Changes in uterine mast cells during the estrous cycle in the Syrian hamster

The Mast Cells of the Mammalian Central Nervous System

Endogenous Heparin

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