Preliminary results and evidence of early regeneration in inferior alveolar nerve fibers

Libersa, Philippe; Roze, David; Libersa, Jean-Claude; Courtand, G.; Picquet, Florence

doi:10.1007/s00276-002-0068-8

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…[30][31][32] Now, with evidence that redundant or convoluted geometry of grafts in the rodent model does not preclude or otherwise affect nerve regeneration, a more diverse array of experimental models to study subtypes of nerve may be developed for preclinical investigation. Urologists have particular interest in cavernous nerve regeneration, [33][34][35] dentists in inferior alveolar nerve regeneration, [36][37][38] and otolaryngologists in facial and other cranial nerve regeneration. [39][40][41] Considerations of graft geometry could also potentially inform decisions on nerve reconstruction.…”

Section: Discussionmentioning

confidence: 99%

Regeneration through Nerve Isografts is Independent of Nerve Geometry

Kawamura

Hadlock

Fox

et al. 2005

J reconstr Microsurg

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Investigators have theorized that tortuosity in nerve grafts may adversely affect nerve regeneration. This study investigated the effect of graft configuration and redundancy on regeneration across 2.5-cm rat sciatic nerve isografts. Thirty-two Lewis rats were randomized to four nerve grafting groups defined by gap distance and isograft conformation. In Group 1, grafts were interposed into a 2-cm gap, resulting in mild graft redundancy. In Groups 2 and 3, grafts were tacked in sinusoidal or omega-shaped configurations, respectively, to bridge a 0.5-cm gap. In Group 4, grafts were interposed after 1 cm of native sciatic nerve was resected, resulting in no graft redundancy and an interstump distance of 2.5 cm. At 6 weeks, nerve tissue was harvested; subsequent histomorphometric analysis revealed no significant differences in regeneration between groups. These data suggest that regeneration through isografts is independent of the graft geometry and redundancy.

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