Preliminary Results From the US Zika Pregnancy Registry

Muller, William J.

doi:10.1001/jama.2016.18632

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…Even with asymptomatic infection, pregnant women have congenital anomalies in a similar rate as symptomatic women. The rate of birth defects in the cohort in the United States was 6% among women with or without ZIKV symptoms [23,26]. The rate of infection among the United States territories' cohorts was 7% among symptomatic women and 8% among asymptomatic women [22].…”

Section: Transmission Risks By Maternal Symptomatologymentioning

confidence: 96%

Zika Virus Infection in Pregnancy: Maternal, Fetal, and Neonatal Considerations

Zorrilla

García

Fragoso

et al. 2017

The Journal of Infectious Diseases

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An infection with the Zika virus (ZIKV) is usually mild, with nonspecific symptoms and most often asymptomatic. However, because of its causal relationship with severe congenital malformations, the ZIKV epidemic became an imperative for mobilization, renewed strategies for vector control, and biomedical research. A congenital Zika syndrome (CZS) has been characterized with 5 distinctive features that focus on brain development abnormalities (including microcephaly and brain calcifications), retinal manifestations, and defects on extremities including congenital contractures and hypertonia. The CZS could be just "the tip of the iceberg", pending the documentation of a spectrum of disease that could manifest later in life, from mild dysfunction to severe disease. It will be a matter of time for neurodevelopmental abnormalities, learning disabilities, and other unknown but yet-to-be-described outcomes to be associated with intrauterine ZIKV infection. In addition, ZIKV infection during pregnancy has been associated with other adverse outcomes. Reports mostly include ZIKV-affected pregnancies, and it will be difficult to clearly establish causality without appropriate control groups. We are summarizing some of the known or reported consequences of such infection during pregnancy. Women of reproductive age and particularly pregnant women are the most vulnerable to the adverse consequences of the ZIKV epidemic. Vector control programs need to be expanded to curtail new infections. Research is needed to develop safe and effective treatments, a preventive or therapeutic vaccine, and specific and sensitive tests and to diagnose and identify correlates of long-term immunity. Vaccines and treatments should be safe to be used in pregnancy. To do nothing would allow thousands of pregnant women to expose their fetuses to an infection that causes birth defects and other problems. Prenatal diagnosis technology development is necessary to be able to predict or diagnose adverse fetal outcomes related to ZIKV. Moreover, these tests should be used in a manner similar to the testing/screening method for neural tube defects and common chromosomal anomalies during prenatal care.

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Section: Transmission Risks By Maternal Symptomatologymentioning

confidence: 96%

Zika Virus Infection in Pregnancy: Maternal, Fetal, and Neonatal Considerations

Zorrilla

García

Fragoso

et al. 2017

The Journal of Infectious Diseases

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“…As described above, ZIKV infection can result in neurodegenerative disorders, GBS, fetal abnormalities, and fetal microcephaly following infection of pregnant women (Faria et al, 2016; Driggers et al, 2016; Tang et al, 2016; Dang et al, 2016; Garcez et al, 2016; Muller and Miller, 2016). There are currently >3000 pregnant American women with laboratory signs of ZIKV infection (https://www.cdc.gov/zika/geo/pregwomen-uscases.html).…”

Section: Current Status Of Antiviral Therapeutics (Raymond F Schimentioning

confidence: 97%

Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

et al. 2017

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In response to the outbreak of Zika virus (ZIKV) infection in the Western Hemisphere and the recognition of a causal association with fetal malformations, the Global Virus Network (GVN) assembled an international taskforce of virologists to promote basic research, recommend public health measures and encourage the rapid development of vaccines, antiviral therapies and new diagnostic tests. In this article, taskforce members and other experts review what has been learned about ZIKV-induced disease in humans, its modes of transmission and the cause and nature of associated congenital manifestations. After describing the make-up of the taskforce, we summarize the emergence of ZIKV in the Americas, Africa and Asia, its spread by mosquitoes, and current control measures. We then review the spectrum of primary ZIKV-induced disease in adults and children, sites of persistent infection and sexual transmission, then examine what has been learned about maternal-fetal transmission and the congenital Zika syndrome, including knowledge obtained from studies in laboratory animals. Subsequent sections focus on vaccine development, antiviral therapeutics and new diagnostic tests. After reviewing current understanding of the mechanisms of emergence of Zika virus, we consider the likely future of the pandemic.

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“…Whereas testing of symptomatic individuals provides helpful information for health practitioners to identify cases and for public health agencies to alert communities and strengthen surveillance systems, the need for ZIKV detection is not limited to symptomatic infections. A high proportion of individuals infected with ZIKV are asymptomatic, and due to the risk of congenital abnormalities associated with ZIKV infection [9][10][11][12][13][14], prolonged viremia in pregnant women [15], and documented sexual transmission [6,8,[16][17][18][19] testing algorithms must also account for large groups of asymptomatic individuals. Current guidelines from the Centers for Disease Control and Prevention (CDC) recommend the testing of pregnant women with possible exposure to the ZIKV during the first 12 weeks after travel and all persons with clinical illness and suspected exposure [20].…”

mentioning

confidence: 99%

Diagnosis of Zika Virus Infections: Challenges and Opportunities

Muñoz‐Jordán

2017

The Journal of Infectious Diseases

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Accurate diagnosis of Zika virus (ZIKV) infections has become a pressing need for the effective prevention and control of the epidemic. The findings that ZIKV infections are associated with birth defects and neurologic disease, and that the virus can be sexually transmitted, accentuate the need for accurate diagnostic testing for different applications new to the arbovirus field. Antibody response to related flaviviruses has long been known to be cross-reactive, and antibody detection of ZIKV is nonspecific in populations previously exposed to any of the four dengue viruses or West Nile virus, or vaccinated against yellow fever virus. Therefore, the diagnosis of ZIKV infections has increasingly depended on detection by nucleic acid tests. During the recent epidemic, tests authorized for emergency use have been utilized by public health laboratories and the commercial sector, but a more dependable and responsive diagnostic testing has yet to be developed.

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Preliminary Results From the US Zika Pregnancy Registry

Cited by 4 publications

References 14 publications

Zika Virus Infection in Pregnancy: Maternal, Fetal, and Neonatal Considerations

Zika Virus Infection in Pregnancy: Maternal, Fetal, and Neonatal Considerations

Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

Diagnosis of Zika Virus Infections: Challenges and Opportunities

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