Preliminary results of a magnetic resonance imaging (MRI) study of the pig brain placed in stereotaxic conditions

Marcilloux, J.C.; Felix, Marie-Bernadette; Rampin, Olivier; Stoffels, C.; Iba-Zizen, M. T.; Ea, Cabanis; Laplace, J.P.; Albé-Fessard, D

doi:10.1016/0304-3940(93)90452-q

Cited by 7 publications

(5 citation statements)

References 4 publications

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“…One of the first studies that used MRI in pigs was conducted in 1993. In that study, investigators acquired structural images from pigs and then compared the images to postmortem histological sections (33). This work was further expanded upon and refined in 2000 to map histological data onto the MR images (34).…”

Section: Using Mri To Assess Brain Development In Pigletsmentioning

confidence: 99%

The Domestic Piglet: An Important Model for Investigating the Neurodevelopmental Consequences of Early Life Insults

Conrad

Johnson

2015

Annu. Rev. Anim. Biosci.

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Insults in the prenatal and early postnatal period increase the risk for behavioral problems later in life. One hypothesis is that pre- and postnatal stressors influence structural and functional brain plasticity. Understanding the mechanisms is important, but progress has lagged because certain studies in human infants are impossible, while others are extremely difficult. Furthermore, results from popular rodent models are difficult to translate to human infants owing to the substantial differences in brain development and morphology. Because it overcomes some of these obstacles, the domestic piglet has emerged as an important model. Piglets have a gyrencephalic brain that develops similar to the human brain and that can be assessed in vivo by using clinical-grade neuroimaging instruments. Furthermore, owing to their precocial nature, piglets can be weaned at birth and used in behavioral testing paradigms to assess cognitive behavior at an early age. Thus, the domestic piglet represents an important translational model for investigating the neurodevelopmental consequences of early life insults.

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Section: Using Mri To Assess Brain Development In Pigletsmentioning

confidence: 99%

The Domestic Piglet: An Important Model for Investigating the Neurodevelopmental Consequences of Early Life Insults

Conrad

Johnson

2015

Annu. Rev. Anim. Biosci.

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“…This led the neurobiology group of Laplace to initiate, as from 1986, the preparation of a specific stereotaxic atlas of the whole brain [62]. To secure the technical conditions of this intricate work and to allow an accurate approach to the integrative processes occurring in various central nervous structures, a specific stereotaxic technique was developed for the pig [126] and preliminary studies were conducted with magnetic resonance imaging [127].…”

Section: Central and Peripheral Control Of Food Intake And Digestive mentioning

confidence: 99%

Forty years of achievement in french research on digestive physiology in the pig

Laplace¹,

Aumaı̂tre²,

Rérat³

2001

Reprod. Nutr. Dev.

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-The contribution of the research group set up by Rérat in the early 1960s in Jouy-en-Josas, and then expanded to Rennes, is summarised. As digestive processes are a major key to the nutritional status of monogastric animals, original methodologies based on advanced experimental surgery were developed in the pig to quantify the digestion and absorption yield, to know their factors of variation, and to understand their physiological and nutritional consequences. The group also extended its expertise to the control of food intake, the role of the nervous system and regulatory peptides, and several biomedical gut-related topics. pig / digestion / absorption / neurohumoral regulation / adaptationRésumé -Réalisations et succès de la recherche française : quarante ans de physiologie digestive chez le porc. Dès le début des années 60, un groupe de recherches a été constitué à l'initiative de A. Rérat à Jouy-en-Josas pour étudier divers aspects de la physiologie digestive chez le porc. Leur exploration a fourni des clés essentielles pour la maîtrise du statut nutritionnel chez cette espèce monogastrique, et un instrument d'amélioration de la production porcine. Ce groupe s'est élargi au fil des années et a même essaimé dans les années 80, notamment à Rennes. Il a apporté une contribution essentielle par le développement de méthodologies nouvelles généralement basées sur une chirurgie expérimentale très élaborée. Ces approches ont fourni de nombreux travaux originaux qui ont permis de décrire les processus de digestion (motricité, transit, sécrétions, hydrolyses enzymatiques

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“…Hence it is also an appropriate model for traumatic injury of the developing brain frequently ex- amined by MRI [4,7,8] . All these studies, including those on un-lesioned pig brains [9,10] , have been performed in anesthetized animals. In contrast, there is remarkable scarcity in information on functional MRI (fMRI) responses in conscious pigs, allowing to relate structure to function [11] .…”

Section: Introductionmentioning

confidence: 99%

Postnatal Changes in Functional Activities of the Pig’s Brain: A Combined Functional Magnetic Resonance Imaging and Immunohistochemical Study

Fang

Lorke²,

Li³

et al. 2005

Neurosignals

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Developmental changes in brain activation after pain stimulation and after passive movement of the hind paw were assessed by functional magnetic resonance imaging (fMRI) in pigs of postnatal ages 2, 4 and 6 months. Response patterns were correlated with histological maturation parameters. At 2 months, fMRI failed to detect brain activation after pain stimulation and revealed weak, but widespread activation after passive movement. At 4 months, strong reaction of numerous cortical areas on the contralateral side was seen after pain stimulation. Following passive movement, activation was weaker but more widespread, and the brainstem was also involved. By 6 months, cortical activation became more restricted to the contralateral sensory cortex and brainstem after pain stimulation and to the contralateral sensory and ipsilateral premotor and motor cortices after passive movement. Neocortical synaptophysin immunoreaction increased significantly between 2 and 4 months and slightly decreased by 6 months. The density of GABA-immunoreactive neurons and fibers significantly increased, reaching a maximum at 6 months. Our studies indicate that remodeling of synapses and development of inhibitory GABA neurons last until 6 months postnatally, when the fMRI response of the pig’s brain also attains its mature adult pattern.

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Preliminary results of a magnetic resonance imaging (MRI) study of the pig brain placed in stereotaxic conditions

Cited by 7 publications

References 4 publications

The Domestic Piglet: An Important Model for Investigating the Neurodevelopmental Consequences of Early Life Insults

The Domestic Piglet: An Important Model for Investigating the Neurodevelopmental Consequences of Early Life Insults

Forty years of achievement in french research on digestive physiology in the pig

Postnatal Changes in Functional Activities of the Pig’s Brain: A Combined Functional Magnetic Resonance Imaging and Immunohistochemical Study

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