Preliminary Results of a Phase I/II Study of Simultaneous Boost Irradiation Radiotherapy for Locally Advanced Nasopharyngeal Carcinoma

Abstract

7%) showing partial remission.The most frequently observed acute toxicities during the concurrent chemoradiotherapy were mucositis and leucopenia. Four patients (6.9%) had RTOG grade 3 mucositis, whereas four patients (6.9%) had grade 3 leucopenia. No patient had grade 4 acute toxicity. Three (5.17%) of the patients exhibited injury to the brain on routine MRI examination, with a median observation of 32 months (range, 25-42months). All of them were RTOG grade 0. The 3-year overall, regional-free and distant metastasis-free survival rates were 85%, 94% and 91%, respectively. Conclusion: Simultaneous boost irradiation radiotherapy is feasible in patients with locally advanced nasopharyngeal carcinoma. The results showed excellent local control and overall survival, with no significant increase the incidence of radiation brain injury or the extent of damage. A larger population of patients and a longer follow-up period are needed to evaluate ultimate tumor control and late toxicity.

Whole-liver Radiotherapy Concurrent with Chemotherapy as a Palliative Treatment for Colorectal Patients with Massive and Multiple Liver Metastases: a Retrospective Study

“…We found that conventional fraction intense-modulated radiotherapy reduced liver damage and encouraged more normal cell regeneration than hyperfractioned radiotherapy, according to radiation biology (Dimri et al, 2013). The use of IMRT may improve the ability to deliver high doses to the planned target volume while preserving the integrity of the surrounding normal tissues (Xiang et al, 2013). 5-Fu drugs can enhance radiosensitivity without increasing liver damage, according to many studies (Zeng et al, 2004).…”

Reirradiation with Robotic Stereotactic Body Radiotherapy for Recurrent Nasopharyngeal Carcinoma

“…However, dose escalation has been found relevant with improved survival in previous studies (Wang, 1987). The use of IMRT has shown encouraging results with a survival rate of 60-62% at 5 years (Low et al, 2006;Seo et al, 2009;Koutcher et al, 2010;Chee Ee Phua et al, 2013;Phua Chee Ee et al, 2013;Xiang et al, 2013;).…”

Glycididazole Sodium Combined with Radiochemotherapy for Locally Advanced Nasopharyngeal Carcinoma

“…But 5-year survival rate is only 40% and the recurrence rate could reach as high as 42% if only radiotherapy is considered because most patients with nasopharyngeal carcinoma are diagnosed with advanced disease ( . In recent years, studies have shown that most of local recurrence after radiotherapy of nasopharyngeal carcinoma (NPC) occurred within the field of radiation, and it is estimated that recurrence within the radiation field accounting for 60% of the total number of recurrence (Sun et al, 2013;Xiang et al, 2013;Xie et al, 2013;Abbasi et al, 2014;Cai et al, 2014;Cheah et al, 2014;Chen et al, 2014;Deng et al, 2014;. The existence of hypoxic cells may be one of the main factors that cause the failure of radiotherapy.…”