Preliminary results of MR imaging with superparamagnetic iron oxide in pancreatic and retroperitoneal disorders.

Torres, Gladys M.; Erquiaga, Eugenio; Ros, Pablo R.; Burton, Sharon S.; Barreda, R.; Langmo, L. S.; Kennedy, Stuart

doi:10.1148/radiographics.11.5.1947314

Cited by 8 publications

(2 citation statements)

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“…Lip-Gd@AuNPs are the first MRI contrast agents of any type, either paramagnetic or superparamagnetic, to effectively image the pancreas. Targeting to the pancreas is a significant challenge because the organ is hypovascular and surrounded by abundant fibrous stroma and fatty tissue. , Other CA formulations utilizing iron oxide, , manganese, , or gadolinium , for MR imaging of the pancreas have been unconvincing. In this context, the efficacy of Lip-Gd@AuNPs for pancreatic MRI is compelling, but several features of this platform need further exploration.…”

Section: Discussionmentioning

confidence: 99%

Gd(III)-Dithiolane Gold Nanoparticles for T₁-Weighted Magnetic Resonance Imaging of the Pancreas

et al. 2016

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Pancreatic adenocarcinoma has a 5 year survival of approximately 3% and median survival of 6 months and is among the most dismal of prognoses in all of medicine. This poor prognosis is largely due to delayed diagnosis where patients remain asymptomatic until advanced disease is present. Therefore, techniques to allow early detection of pancreatic adenocarcinoma are desperately needed. Imaging of pancreatic tissue is notoriously difficult, and the development of new imaging techniques would impact our understanding of organ physiology and pathology with applications in disease diagnosis, staging, and longitudinal response to therapy in vivo. Magnetic resonance imaging (MRI) provides numerous advantages for these types of investigations; however, it is unable to delineate the pancreas due to low inherent contrast within this tissue type. To overcome this limitation, we have prepared a new Gd(III) contrast agent that accumulates in the pancreas and provides significant contrast enhancement by MR imaging. We describe the synthesis and characterization of a new dithiolane-Gd(III) complex and a straightforward and scalable approach for conjugation to a gold nanoparticle. We present data that show the nanoconjugates exhibit very high per particle values of r1 relaxivity at both low and high magnetic field strengths due to the high Gd(III) payload. We provide evidence of pancreatic tissue labeling that includes MR images, post-mortem biodistribution analysis, and pancreatic tissue evaluation of particle localization. Significant contrast enhancement was observed allowing clear identification of the pancreas with contrast-to-noise ratios exceeding 35:1.

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Section: Discussionmentioning

confidence: 99%

Gd(III)-Dithiolane Gold Nanoparticles for T₁-Weighted Magnetic Resonance Imaging of the Pancreas

et al. 2016

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“…Die CT, mö glichst als Spiral-CT, mit der Applikation von Kontrastmittel ist v. a. aufgrund der hö heren Verfü gbarkeit immer noch das Standarduntersuchungsverfahren in der bildgebenden Diagnostik primä rer retro-peritonealer Tumoren [13,23,32]. B. ein myxoider Tumor mit der gleichen Densitä t oder Signalintensitä t wie eine Cyste darstellen kann und erst nach Kontrastverstä rkung reticulä re Verä nderungen in den myxoiden Komponenten zu sehen sind [20] Weichteiltumoren konnte hierdurch aber nicht erreicht werden [33]. B. an den Extremitä ten, ist die MRT der CT an Darstellung und Abgrenzung des Tumors zum umgebenden Gewebe ü berlegen und gibt mehr Informationen ü ber eine mö gliche Organ-, Gefäßoder Nerveninfiltration [29].…”

Section: Bildgebende Diagnostikunclassified

Chirurgische Relevanz bildgebender Diagnostik bei abdominellen Tumoren – Entscheidungswege beim Retroperitoneum

Schildberg

Löhe

Berger

1997

Chirurg

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The indication for surgical treatment of tumors of the retroperitoneum should not depend on findings of radiological examinations, because all radiographic procedures lack tissue specificity. Instead, it can only be determined histologically after an open biopsy or resection of the tumor, which should always be attempted. With the help of appropriate radiological examinations, a retroperitoneal mass will not only be detected, but the relationship to the adjacent anatomical structures will also be delineated. Therefore, valid information for planning the operation and estimating the morbidity and mortality can be provided for the surgeon.

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Liquid oral magnetic particles as a gastrointestinal contrast agent for MR imaging: Efficacy in vivo

Rubin

Muller

Sidhu

et al. 1993

Magnetic Resonance Imaging

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Recent in vitro studies suggested there is an optimal range of concentration and viscosity for a liquid formulation of oral magnetic particles (WIN 39996) for magnetic resonance (MR) imaging of the gastrointestinal (GI) tract. To determine whether this formulation is also effective in vivo and whether differing viscosity and administration regimen affect GI distribution of the contrast agent, a range of concentrations of iron (75, 150, and 200 micrograms/mL) and viscosities (1, 150, and 600 cp) were imaged in dogs at 1.5 T with conventional spin-echo and fat-saturation pulse sequences. The effects of dose regimen (single vs divided dose) and subject position (supine vs right lateral decubitus) were also studied. The 75 and 200 micrograms/mL concentrations were unacceptable for MR imaging, while 150 micrograms/mL was effective. The GI distribution of the contrast agent was affected jointly by viscosity, subject position, and dose regimen. The 150 micrograms/mL formulation produced excellent GI contrast enhancement in vivo for both 150- and 600-cp viscosities. The choice of optimal viscosity may depend on the preferred administration regimen.

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Preliminary results of MR imaging with superparamagnetic iron oxide in pancreatic and retroperitoneal disorders.

Cited by 8 publications

References 0 publications

Gd(III)-Dithiolane Gold Nanoparticles for T₁-Weighted Magnetic Resonance Imaging of the Pancreas

Gd(III)-Dithiolane Gold Nanoparticles for T₁-Weighted Magnetic Resonance Imaging of the Pancreas

Chirurgische Relevanz bildgebender Diagnostik bei abdominellen Tumoren – Entscheidungswege beim Retroperitoneum

Liquid oral magnetic particles as a gastrointestinal contrast agent for MR imaging: Efficacy in vivo

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Preliminary results of MR imaging with superparamagnetic iron oxide in pancreatic and retroperitoneal disorders.

Cited by 8 publications

References 0 publications

Gd(III)-Dithiolane Gold Nanoparticles for T1-Weighted Magnetic Resonance Imaging of the Pancreas

Gd(III)-Dithiolane Gold Nanoparticles for T1-Weighted Magnetic Resonance Imaging of the Pancreas

Chirurgische Relevanz bildgebender Diagnostik bei abdominellen Tumoren – Entscheidungswege beim Retroperitoneum

Liquid oral magnetic particles as a gastrointestinal contrast agent for MR imaging: Efficacy in vivo

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Gd(III)-Dithiolane Gold Nanoparticles for T₁-Weighted Magnetic Resonance Imaging of the Pancreas

Gd(III)-Dithiolane Gold Nanoparticles for T₁-Weighted Magnetic Resonance Imaging of the Pancreas