Preliminary results on long-term follow-up of systemic sclerosis patients under extracorporeal photopheresis

Gambichler, Thilo; Özsoy, Olcay; Bui, Duyen; Scheel, Christiane H.; Susok, Laura

doi:10.1080/09546634.2021.1925078

Cited by 10 publications

(21 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, we identified 18 completed nonrandomized studies (19 references), all of which had a case‐only design 28–46 . Of those 19 references, one article 44 reported follow‐up data from previously published cases 31 .…”

Section: Resultsmentioning

confidence: 99%

“…In addition, we identified 18 completed nonrandomized studies (19 references), all of which had a case-only design. [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] Of those 19 references, one article 44 reported follow-up data from previously published cases. 31 In addition, we identified one ongoing case-only study retrieved from ClinicalTrials.gov.…”

Section: Search Resultsmentioning

confidence: 99%

“…Recently, Gambichler 34 reported survival data on SSc patients treated by ECP. Of 59 participants, 51 (86.4%) survived and eight (13.6%) died within a 20‐year follow‐up period.…”

Section: Discussionmentioning

confidence: 99%

“…Without a control for the effects of time, any changes may have occurred anyway. We identified 18 studies with a case‐only and a before‐and‐after design 28–46 . Even though some of the studies reported beneficial ECP effects in SSc patients, those studies cannot provide definitive information on ECP efficacy or adverse treatment effects.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Extracorporeal photopheresis for systemic sclerosis: A meta‐analysis of randomized clinical trials

Delbrück

Gambichler

Susok

et al. 2022

Dermatologic Therapy

Self Cite

View full text Add to dashboard Cite

Systemic sclerosis (scleroderma) (SSc) is a rare autoimmune disorder characterized by excessive production of collagen. Extracorporeal photopheresis (photochemotherapy, phototherapy) (ECP) involves repeated exposure of peripheral blood lymphocytes to ultraviolet A (UVA) radiation. The rationale for treating patients with SSc by ECP lies in its presumed immunomodulatory effects, though, rigorous data on the specific effects of ECP are limited, particularly in patients with SSc. The objective was to evaluate the effects of extracorporeal photopheresis as a treatment modality for patients with SSc. We searched the databases CENTRAL and MEDLINE on 13 March 2022 and included randomized clinical trials (RCTs) on patients diagnosed with SSc and treated with ECP. Primary outcome was the change of skin scores. We applied independent extraction and judgment by multiple observers. We conducted a meta‐analysis applying the inverse variance method and the random effects model; the main outcome measure was standard mean difference of skin scores. We identified three relevant RCTs including 162 randomized (132 analyzed) people who received ECP in a simple parallel design. Pooled data of the three studies were indifferent. We estimated a standard mean difference from baseline of −0.11 (95% confidence interval −0.45 to 0.23), p = 0.54, I2 = 0%. We did not identify serious treatment‐related adverse events. The evidence base for extracorporeal photopheresis on skin scores in patients with systemic sclerosis was not high enough to support a superior effect when compared to no treatment, sham photopheresis, or D‐penicillamine.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Search Resultsmentioning

confidence: 99%

“…Recently, Gambichler 34 reported survival data on SSc patients treated by ECP. Of 59 participants, 51 (86.4%) survived and eight (13.6%) died within a 20‐year follow‐up period.…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Extracorporeal photopheresis for systemic sclerosis: A meta‐analysis of randomized clinical trials

Delbrück

Gambichler

Susok

et al. 2022

Dermatologic Therapy

Self Cite

View full text Add to dashboard Cite

show abstract

“…Im Verlauf einer langfristigen Photopherese-Therapie zur Behandlung der systemischen Sklerose konnte nicht nur nachgewiesen werden, dass es zu einer Stabilisierung oder sogar Verbesserung des Krankheitsverlaufs bezüglich der Hautveränderungen kommt [4], sondern auch zu einer signifikanten Verlängerung der Überlebenszeit [38]. Im Gegensatz zu den Hautmanifestationen konnten viszerale Manifestationen selbst durch lang andauernde Behandlungen kaum beeinflusst werden.…”

Section: Systemische Skleroseunclassified

Update zur Extrakorporalen Photopherese

Knobler

Valero

Just

2021

hautnah

View full text Add to dashboard Cite

ZusammenfassungVor über 30 Jahren wurde ein von der PUVA abgeleitetes Therapiekonzept zur Behandlung von therapierefraktären kutanen T‑Zell-Lymphomen (CTCL), insbesondere dem Sézary-Syndrom, entwickelt. R. Edelson hat Leukapherese mit Photochemotherapie verbunden, wodurch Zellen des peripheren Blutes extrakorporal nach Photosensibilisierung mittels Psoralen mit UVA-Licht bestrahlt und anschließend rückinfundiert werden. Im Jahr 1987 wurde dieses neue Behandlungskonzept mit dem Namen extrakorporale Photopherese (ECP) erstmals publiziert. Nach den ersten positiven Erfahrungen mit CTCL wurde diese Behandlung bei weiteren Indikationen erfolgreich angewendet, darunter Erkrankungen wie akute und chronische Graft-versus-Host-Reaktion (GvHD), Sklerodermie sowie atopische Dermatitis (AD). Eine zunehmende Anwendung hat die ECP in den letzten Jahren in der Behandlung von akuten und chronischen Abstoßungsreaktionen nach Organtransplantation, insbesondere Herz- und Lungentransplantation, erhalten. Im Jahr 2021 gibt es über 200 Zentren weltweit, welche die ECP erfolgreich einsetzen.

show abstract

Systemic Sclerosis

Orteu,

Denton

2024

Rook's Textbook of Dermatology

View full text Add to dashboard Cite

Preliminary results on long-term follow-up of systemic sclerosis patients under extracorporeal photopheresis

Cited by 10 publications

References 17 publications

Extracorporeal photopheresis for systemic sclerosis: A meta‐analysis of randomized clinical trials

Extracorporeal photopheresis for systemic sclerosis: A meta‐analysis of randomized clinical trials

Update zur Extrakorporalen Photopherese

Systemic Sclerosis

Contact Info

Product

Resources

About