Preliminary Results on the Off-Label Use of Duloxetine for the Treatment of Stress Incontinence after Radical Prostatectomy or Cystectomy

Schlenker, Boris; Gratzke, Christian; Reich, Oliver; Schorsch, I.; Seitz, Michael; Stief, Christian G.

doi:10.1016/j.eururo.2006.01.038

Cited by 77 publications

(39 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7 Similarly, two additional studies found an approximate 50% reduction in pad usage with patients taking duloxetine to manage post-prostatectomy SUI. 5,8 Zarariou and colleagues reported minimal urodynamic improvements, but a significant reduction in clinical pad use after a 3-month course of duloxetine. 9 A Spanish study evaluated the efficacy of duloxetine in 68 patients with post-prostatectomy SUI at least 1 year post-prostatectomy.…”

Section: Discussionmentioning

confidence: 99%

“…19 Several clinical studies investigating the role of duloxetine in post-prostatectomy SUI have been published. 5,[7][8][9][10] Filocamo and colleagues reported duloxetine and pelvic floor physical therapy may allow for earlier return to continence as compared to physical therapy alone following catheter removal in the immediate postoperative period. 7 Similarly, two additional studies found an approximate 50% reduction in pad usage with patients taking duloxetine to manage post-prostatectomy SUI.…”

Section: Discussionmentioning

confidence: 99%

“…6 The use of duloxetine in men is an active area of investigation and represents a potential nonsurgical therapy for post-prostatectomy SUI. 5,[7][8][9][10] The goal of our investigation is to evaluate the efficacy and reported side effects in patients with mild to moderate post-prostatectomy SUI treated with duloxetine.…”

Section: Introductionmentioning

confidence: 99%

“…4 Duloxetine, a selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor, has been shown to decrease SUI by increasing urethral sphincter contractility. 5 The drug inhibits the pre-synaptic reuptake of 5-HT and NE at Onuf's nucleus in the sacral spinal cord. The result is an increase in rhabdosphincter activity due to increased post-synaptic receptor stimulation.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Duloxetine for the treatment of post-prostatectomy stress urinary incontinence

Neff

Guise

Guralnick

et al. 2013

CUAJ

View full text Add to dashboard Cite

E260 research researchCite as: Can Urol Assoc J 2013;7(5-6):e260-2. http://dx.doi.org/10.5489/cuaj.318 Published online May 13, 2013. AbstractObjectives: Stress urinary incontinence (SUI) is a known complication following prostatectomy. Duloxetine, a combined serotonin/ norepinephrine reuptake inhibitor, can decrease SUI by increasing urethral sphincter contractility. We examined the outcomes of patients with mild to moderate post-prostatectomy SUI treated with duloxetine. Methods: We conducted a retrospective review of men treated with duloxetine to manage mild to moderate post-prostatectomy SUI from 2006 to 2012. All patients received oral duloxetine 30 mg once a week, then 60 mg thereafter. Patients were seen one month later to determine drug efficacy and side effects. Results: In total, 94 men were included in the study. Daily pad usage decreased from 2.9 (range: 1-5) to 1.6 (range: 0-4) (p < 0.05). Incontinence Impact Questionnaire (IIQ-7) scores decreased from 13.0 (range: 6-18) to 7.9 (range: 2-16) (p < 0.05). Linear satisfaction scores improved from 0.8 (range: 0-2) to 2.0 (range: 1-3) (p < 0.05). Following a 1-month duloxetine trial, 33/94 (35%) men reported satisfactory SUI improvement and requested to continue the medication. The drug was discontinued in 61/94 (65%) patients due to poor efficacy in 32/94 (34%), intolerable side effects in 14/94 (15%) or both in 15/94 (16%). Reported side effects included fatigue, light-headedness, insomnia, nausea and dry mouth. Conclusions: Duloxetine improved post-prostatectomy SUI in 47/94 (50%) men following a 1-month trial. However, only 33/94 (35%) patients were able to tolerate the drug. Duloxetine may be considered a treatment option for men with mild to moderate post-prostatectomy SUI.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Duloxetine for the treatment of post-prostatectomy stress urinary incontinence

Neff

Guise

Guralnick

et al. 2013

CUAJ

View full text Add to dashboard Cite

show abstract

“…This has to be counterbalanced against the risk of significant side-effects such as nausea, fatigue and insomnia. 8 Alpha-adrenergic blockers have been shown to be useful in very minor degrees of incontinence, while anticholinergic medications have a role if detrusor overactivity is demonstrated.…”

Section: Pharmacotherapymentioning

confidence: 99%