Preliminary results on transmission of <scp>SARS‐CoV</scp>‐2 antibodies to the fetus and serum neutralizing activity

Houhou‐Fidouh, Nadhira; Bucau, Margot; Bertine, Mélanie; Minh, Thu Nguyen Thi; Picone, Olivier; Salakos, Eleonora; Luton, Dominique

doi:10.1002/ijgo.14185

Cited by 2 publications

(2 citation statements)

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“…Evidence of efficient placental SARS-CoV-2 antibodies transfer had been previously demonstrated 25 , 28 , but uncertainties remained regarding the impact of maternal disease severity and the delay required to obtain efficient transfer. Similarly to others, we observed that the placental antibody transfer was proportional to time elapsed since maternal infection 27 – 31 , 36 – 38 . Indeed, Brebant et al .…”

Section: Discussionsupporting

confidence: 88%

“…Although, Flannery et al . 26 detected specific IgG in 86.7% (72/83) of exposed fetuses, information regarding the potential impact of the delay between maternal infection and delivery regarding materno-fetal antibody transfer is still being explored 27 – 31 . Due to the significant protection offered by passive immunization acquired through maternal antibodies to the vulnerable newborn and its potential impact on vaccination campaigns, comparing the efficiency of placental antibody transfer in the first, second, and third trimester of infection with SARS-CoV-2 needs to continue to be explored.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of the transplacental transmission of SARS CoV-2 virus and antibody transfer according to the gestational age at maternal infection

Lucot-Royer,

Nallet,

Vouga

et al. 2024

Sci Rep

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To quantify transplacental transmission of SARS-CoV-2 virus and antibody transfer in pregnant women and their newborns according to the gestational age at maternal infection. A prospective observational multicenter study including pregnant women with a positive RT-PCR or a positive serology for SARS-CoV-2 and compatible symptoms, from April to December 2020, in 11 French maternities. The study was designed to obtain a systematic collection of mother-infant dyad’s samples at birth. SARS-CoV-2 viral load was measured by RT-PCR. IgG and IgM antibodies against the SARS-CoV-2 spike protein were measured by enzyme-linked immunosorbent assay. Antibody concentrations and transplacental transfer ratios were analyzed according to the gestational age at maternal infection. The primary outcome was the rate of SARS CoV-2 materno-fetal transmission at birth. The secondary outcome was the quantification of materno-fetal antibody transfer. Maternal and neonatal outcomes at birth were additionally assessed. Among 165 dyads enrolled, one congenital infection was confirmed {n = 1 (0.63%) IC95% [0.02%; 3.48%]}. The average placental IgG antibody transfer ratio was 1.27 (IC 95% [0.69–2.89]). The transfer ratio increased with increasing time between the onset of maternal infection and delivery (P Value = 0.0001). Maternal and neonatal outcomes were reassuring. We confirmed the very low rate of SARS-CoV-2 transplacental transmission (< 1%). Maternal antibody transfer to the fetus was more efficient when the infection occurred during the first and second trimester of pregnancy.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Analysis of the transplacental transmission of SARS CoV-2 virus and antibody transfer according to the gestational age at maternal infection

Lucot-Royer,

Nallet,

Vouga

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

Transplacental transfer of anti-SARS-CoV-2 neutralizing antibodies in comparison to other pathogens total antibodies

Couffignal

Manchon

Duquesne

et al. 2023

Journal of Clinical Virology

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Preliminary results on transmission of SARS‐CoV‐2 antibodies to the fetus and serum neutralizing activity

Abstract: During pregnancy early third trimester immunization against SARS‐CoV‐2 confers optimal immunity to the neonate.

Cited by 2 publications

References 4 publications

Analysis of the transplacental transmission of SARS CoV-2 virus and antibody transfer according to the gestational age at maternal infection

Analysis of the transplacental transmission of SARS CoV-2 virus and antibody transfer according to the gestational age at maternal infection

Transplacental transfer of anti-SARS-CoV-2 neutralizing antibodies in comparison to other pathogens total antibodies

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