Preliminary Screening of Selected Plant Extracts for Anti Tyrosinase Activity

Abstract

Tyrosinase inhibition is an important approach towards controlling hyper pigmentation. We aimed to screen alcoholic extracts of 11 plants extract for their tyrosinase inhibitory activity. These plants have been used traditionally in the treatment of skin ailments and for the improvement of skin complexion. The extracts were quantified for total phenols, alkaloids and tannins. In vitro tyrosinase inhibition was performed with kojic acid as the positive control. Cell viability was tested on B16 F0 melanoma cells. The extracts of Rosa berberifolia, Punica granatum and Casiia angustifolia showed more than 80% inhibition at 500 mg/ml concentration. Nine of the extracts were also shown to have a high phenolic content greater than 200 mg/g of the plant material. The tyrosinase inhibitory activity of the extracts of Cassia angustifolia, Punica granatum and Rosa berberifolia were comparable with that of the control, kojic acid. The three extracts also showed lesser than 50% cytotoxicity at the concentrations tested. From the screening assays, it is seen that three plants have appreciable tyrosinase inhibitory activity. Hence, these plants may be further evaluated for their use in cosmetics and hyper pigmentation. Preliminary Screening of Selected PlantExtracts for Anti Tyrosinase Activity JOURNAL OF NATURAL REMEDIES AbstractIpomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

Porous Organic Polymer with Free Carboxylic Acids (Carboxy‐POP) for Heterogeneous Catalytic One‐Pot Synthesis of Xanthenes and Acridines

“…The analogous acridines with nitrogen-containing six-membered ring are generally found in plant tissues. [43,44] The core structure of xanthenes is responsible for an array of physicochemical and medicinal properties such as antiviral, [45] antiinflammatory, [45] analgesic, [45] anticancer, [46] antibacterial, [47] antioxidant, [48] etc. In the same vein, acridines also are known to exhibit a number of biological activities, e. g., antitumor, antiasthmatic, antiallergic, antiplatelet, etc.…”

<i>Siddha</i> Therapeutic Approach to Diabetic Nephropathy – A Review

“…It also reduces joint pain, swelling, muscle pain, and headache. In addition, NK also treats infertility, irregular periods, and white discharge 39 . Siddha practitioners use Nilavembu kudineer as a supplementary drug for the effective management of diabetic Nephropathy owing to its antidiabetic and antioxidant properties; it was seen that NK reduces blood urea and serum creatinine in diabetic nephropathy patients.…”

Microwave Hydrodiffusion and Gravity (MHG) Extraction from Different Raw Materials with Cosmetic Applications

“…This cosmetic ingredient offers antioxidant, antimicrobial and anti-tyrosinase activities [13,14]. Brassica rapa tap root extracts also have a potential cosmetic use since its tyrosinase enzymatic inhibition promotes the skin depigmentation [15,16]. For this reason, the authors consider the evaluation of the Brassica rapa var.…”