Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells

Ji, Haiyu; Lou, Xiaowei; Jiao, Jian-shuang; Li, Yang; Dai, Kesheng; Jia, Xiaoyu

doi:10.3390/molecules28041561

Cited by 16 publications

(9 citation statements)

References 44 publications

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“…As shown, the cell percentages in the G0/G1 phase and apoptotic rates in solid tumors of CPG-treated mice were obviously increased (p < 0.05) compared with the model group, whereas the proportions in the S phase were remarkably reduced (p < 0.05), which indicated that the growth of S180 tumor cells in vivo was effectively inhibited by CPG-enhanced cellular immune response. These findings provided valuable insights into potential therapeutic strategies for cancer treatment [34].…”

Section: Cell Cycle Distributions and Apoptotic Rates In Tumorsmentioning

confidence: 92%

Systemic Immunomodulatory Effects of Codonopsis pilosula Glucofructan on S180 Solid-Tumor-Bearing Mice

Fan,

Long,

Gong

et al. 2023

IJMS

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The immune functions of the body are intricately intertwined with the onset and advancement of tumors, and immunotherapy mediated by bioactive compounds has exhibited initial effectiveness in overcoming chemotherapy resistance and inhibiting tumor growth. However, the comprehensive interpretation of the roles played by immunologic components in the process of combating tumors remains to be elucidated. In this study, the Codonopsis pilosula glucofructan (CPG) prepared in our previous research was employed as an immunopotentiator, and the impacts of CPG on both the humoral and cellular immunity of S180 tumor-bearing mice were investigated. Results showed that CPG administration of 100 mg/kg could effectively inhibit tumor growth in mice with an inhibitory ratio of 45.37% and significantly improve the expression of Interleukin-2 (IL-2), Interferon-γ (IFN-γ), and Tumor Necrosis Factor-α (TNF-α). Additionally, CPG clearly enhanced B-cell-mediated humoral immunity and immune-cell-mediated cellular immunity, and, finally, induced S180 cell apoptosis by arresting cells in the G0/G1 phase, which might result from the IL-17 signaling pathway. These data may help to improve comprehension surrounding the roles of humoral and cellular immunity in anti-tumor immune responses.

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Section: Cell Cycle Distributions and Apoptotic Rates In Tumorsmentioning

confidence: 92%

Systemic Immunomodulatory Effects of Codonopsis pilosula Glucofructan on S180 Solid-Tumor-Bearing Mice

Fan,

Long,

Gong

et al. 2023

IJMS

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“…Ji et al. prepared a novel functionalized nanocomposite using alcohol-soluble APS and selenium nanoparticles and found that it was effective in suppressing HepG2 proliferation and accelerating apoptosis by triggering S-phase arrest, thereby stimulating ΔΨm (mitochondrial membrane potential) depletion, increasing the Bax/Bcl-2 ratio, and promoting intracellular reactive oxygen species accumulation ( 127 ). Jiao et al.…”

Section: Anti-tumor Mechanism Of Apsmentioning

confidence: 99%

“…accumulation(127). Jiao et al developed selenium nanoparticles modified with macromolecular weight APS and observed positive results in hepatoma treatment, as indicated by the induction of apoptosis and inhibition of proliferation of HepG2 cells(128).…”

mentioning

confidence: 99%

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

Yang,

Meng,

Zhang

et al. 2024

Front. Oncol.

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The dry root of the soybean plant Astragalus membranaceus (Fisch) Bge. var. mongholicus (Bge) Hsiao or A. membranaceus (Fisch) Bge, Astragali Radix (AR) has a long medicinal history. Astragalus polysaccharide (APS), the natural macromolecule that exhibits immune regulatory, anti-inflammatory, anti-tumor, and other pharmacological activities, is an important active ingredient extracted from AR. Recently, APS has been increasingly used in cancer therapy owing to its anti-tumor ability as it prevents the progression of prostate, liver, cervical, ovarian, and non-small-cell lung cancer by suppressing tumor cell growth and invasion and enhancing apoptosis. In addition, APS enhances the sensitivity of tumors to antineoplastic agents and improves the body’s immunity. This macromolecule has prospects for broad application in tumor therapy through various pathways. In this article, we present the latest progress in the research on the anti-tumor effects of APS and its underlying mechanisms, aiming to provide novel theoretical support and reference for its use in cancer therapy.

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“…In addition, cytotoxicity against HepG2 is also shown for the SeNPs complex with alcohol-soluble astragalus polysaccharide (AASP) isolated from the stems or dried roots of Astragalus membranaceus , and having biologically active effects [ 99 ]. It is known that AASP can inhibit the growth of solid H22 tumors in mice by increasing the level of serum cytokines (TNF-α, IL-2, and IFN-γ) and the activity of immune cells (macrophages, lymphocytes, and NK cells), therefore inducing apoptosis of tumor cells [ 100 ].…”

Section: The Role Of Nanomedicine In the Treatment Of Liver Pathologi...mentioning

confidence: 99%

The Role of Selenium Nanoparticles in the Treatment of Liver Pathologies of Various Natures

Goltyaev

Varlamova

2023

IJMS

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The liver is the body’s largest gland, and regulates a wide variety of physiological processes. The work of the liver can be disrupted in a variety of pathologies, the number of which is several hundred. It is extremely important to monitor the health of the liver and develop approaches to combat liver diseases. In recent decades, nanomedicine has become increasingly popular in the treatment of various liver pathologies, in which nanosized biomaterials, which are inorganic, polymeric, liposomal, albumin, and other nanoparticles, play an important role. Given the need to develop environmentally safe, inexpensive, simple, and high-performance biomedical agents for theragnostic purposes and showing few side effects, special attention is being paid to nanoparticles based on the important trace element selenium (Se). It is known that the metabolism of the microelement Se occurs in the liver, and its deficiency leads to the development of several serious diseases in this organ. In addition, the liver is the depot for most selenoproteins, which can reduce oxidative stress, inhibit tumor growth, and prevent other liver damage. This review is devoted to the description of the results of recent years, revealing the important role of selenium nanoparticles in the therapy and diagnosis of several liver pathologies, depending on the dose and physicochemical properties. The possibilities of selenium nanoparticles in the treatment of liver diseases, disclosed in the review, will not only reveal the advantages of their hepatoprotective properties but also significantly supplement the data on the role of the trace element selenium in the regulation of these diseases.

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Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells

Cited by 16 publications

References 44 publications

Systemic Immunomodulatory Effects of Codonopsis pilosula Glucofructan on S180 Solid-Tumor-Bearing Mice

Systemic Immunomodulatory Effects of Codonopsis pilosula Glucofructan on S180 Solid-Tumor-Bearing Mice

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

The Role of Selenium Nanoparticles in the Treatment of Liver Pathologies of Various Natures

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