Preliminary studies of Mammea americana L. (Guttiferae) bark/latex extract point to an effective antiulcer effect on gastric ulcer models in mice

Toma, Walber; Hiruma-Lima, Clélia Akiko; Guerrero, Ricardo O; Brito, Alba Regina Monteiro Souza

doi:10.1016/j.phymed.2003.06.009

Cited by 53 publications

(32 citation statements)

References 18 publications

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“…This exposure can result in gastric ulcer, which is the most prevalent intestinal disorder [1,2]. Different factors such as the infection of stomach by Helicobacter pylori, alcohol, cigarette smoking and frequent use of non-steroidal antiinflammatory drugs can lead to the formation of gastric ulcers [3,4].…”

Section: Introductionmentioning

confidence: 99%

Ulcer protective effect of Byrsocarpus coccineus leaf extract in different experimental animal models

Christian¹,

Monday²,

Linus³

et al. 2015

J Coast Life Med

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Section: Introductionmentioning

confidence: 99%

Ulcer protective effect of Byrsocarpus coccineus leaf extract in different experimental animal models

Christian¹,

Monday²,

Linus³

et al. 2015

J Coast Life Med

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“…Therefore, a useful method for prevention of recurrence is needed. Food and other natural resources have been attracting attention as a preventive method, and many studies have been performed (Ch et al, 2004;Toma et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models

Mahesh¹,

Jeyachandran²,

Rao³

et al. 2012

Rev. bras. farmacogn.

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Abstract:In the present study, the ethanolic root extract of Desmodium gangeticum (L.) DC., Fabaceae, (EDG), have been studied in various acute and chronic ulcer mouse models. Oral administration of root extract, signifi cantly decrease the ulcer index and lesion number in a dose dependent manner against ethanol induced acute gastric ulcer in mice. In gastric ulcerated animal that received high dose of 150 mg/kg EDG, the mucosa showed no ulceration with slight focal congestion and the glands appeared normal. Pylorus ligated mice, pretreated with EDG showed signifi cant decrease in ulcerous activity under chronic condition. The highest dose (150 mg/kg) of the extract provoked a marked increase in protein and glutathione levels, when compare to control. Furthermore, gastric juice, free acidity and total acid output were inhibited in a dose-dependent manner at p<0.05 level. Our results indicate that the EDG possess gastroprotective activity and increasing regeneration of damaged gastric mucosa and thus safe for human use.

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“…The gastric mucosa is continuously exposed to potentially injurious agents such as acid, pepsin, bile acids, food ingredients, bacterial products (Helicobacter pylori) and drugs. These agents have been implicated in the pathogenesis of gastric ulcer, including enhanced gastric acid and pepsin secretion, inhibition of prostaglandin synthesis and cell proliferation growth, diminished gastric blood flow and gastric motility 1 .…”

Section: Introductionmentioning

confidence: 99%

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2011

IJPSR

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The objective of present study is to evaluate the anti ulcer activity of ethanol extract of leaves of Heliotropium indicum. The ethanol extract of H. indicum was investigated for its anti ulcer activity against Aspirin plus pylorus ligation induced gastric ulcer in rats, HCl-Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats. The antiulcer activity was assessed by determining and comparing gastric volume, free acidity and ulcer inhibition in aspirin plus pylorus ligation induced gastric ulcer model. The number of lesions in HCI-Ethanol induced peptic ulcer model and mean score value of ulcer inhibition in water immersion stress induced ulcer model. A significant antiulcer activity of plant extract was observed in all the models. Pylorus ligation model showed significant reduction in gastric volume, free acidity and ulcer index as compared to control. Also extract showed significant ulcer inhibition in HCl-Ethanol induced ulcer and ulcer protection index in stress induced ulcer. This present study indicates that Heliotropium indicum leaves extract have potential anti ulcer activity in the three models tested.

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Preliminary studies of Mammea americana L. (Guttiferae) bark/latex extract point to an effective antiulcer effect on gastric ulcer models in mice

Cited by 53 publications

References 18 publications

Ulcer protective effect of Byrsocarpus coccineus leaf extract in different experimental animal models

Ulcer protective effect of Byrsocarpus coccineus leaf extract in different experimental animal models

Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models

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