Preliminary Studies of the Caries Inhibiting Potential and Acute Toxicity of Sodium Monoflltorophosphate

Acute Oral Toxicity of Sodium Fluoride and Monofluorophosphate Separately or in Combination in Rats

“…The major finding from the present studies, which is at variance with two previous reports [Shourie et al, 1950;Lim et al, 1978], was the lack of a significant difference between the acute toxic potentials of fluo ride from NaF and MFP. The current results are in ac cord, both qualitatively and quantitatively, with those reported by Gruninger et al [1988], who conducted their studies at the American Dental Association Health Foundation Research Institute.…”

“…Al though it seems unlikely, there might be differences among the various strains of rats that could affect the gastrointestinal absorption of fluoride from MFP, but nothing is known about this subject as yet. In this re gard, Shourie et al [1950] identified their rats only as 'albino', Lim et al [1978] used 'white Rochester' rats while Gruninger et al [1988] and the present studies used Sprague-Dawley rats.…”

“…The rats used by Shourie et al [1950] had body weights in the 200-to 300-gram range. Thus, they would have been considerably older than those of the current studies (152-202 g) and those used by Gruninger et al [1988] (175-200 g).…”

“…In their study with rats, Shourie et al [1950] reported 24-hour LD5" val ues of 36 and 75 mg F/kg, respectively. Lim et al [1978], whose study involved mice, reported values of 44 and 94 mg F/kg, respectively.…”

The Reaction of Monofluorophosphate with Apatite

“…During investigations into the anticaries activity of fluorine compounds it was found that sodium monofluorophosphate was effective in hamsters [Shourie et al, 1950] and in rats [Zipkin and McClure, 1951], A topical application to children's teeth also gave positive results [Hawes et al, 1954]. This was followed by other clinical studies, e.g.…”