Preliminary Studies on Two Vegetable Oil Based Self Emulsifying Drug Delivery System (SEDDS) for the Delivery of Metronidazole, A Poorly Water Soluble Drug

Obitte, Nicholas C.; Ezeiruaku, H.; Onyishi, V.I.

doi:10.3923/jas.2008.1950.1955

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…The study showed that self-emulsification occurred within the GIT with the use of surfactant oil solutions such as Miglyol 812, thus allowing the use of soft gelation-encapsulated formulation for effective drug delivery. This study and many other similar studies [107,108] paved the road for self-emulsification drug delivery systems. The formulation of SEDDS, especially excipients, are not taken as a whole but rather in the form of FAs.…”

Section: Drug Delivery System Of a Lipid-based Formulation Using Psupporting

confidence: 60%

“…A SEDDS formulation involving metronidazole was tested using both PO and PKO. The result from the study showed quick drug release and both oils offered stable formulation when blended with metronidazole, resulting in the absence of precipitation [107]. Apart from that, palm oil FA in SEDDS formulation provides enhanced capacity and permeability.…”

Section: Drug Delivery System Of a Lipid-based Formulation Using Pmentioning

confidence: 99%

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Palm Oil in Lipid-Based Formulations and Drug Delivery Systems

Goon¹,

Kadir²,

Latip³

et al. 2019

Biomolecules

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Palm oil is natural oil packed with important compounds and fatty acids ready to be exploited in lipid-based formulations and drug delivery. Palm oil and palm kernel oil contain long-chain and medium-chain triglycerides, respectively, including phytonutrients such as tocotrienol, tocopherol and carotenes. The exploitation of these compounds in a lipid-based formulation would be able to address hydrophobicity, lipophilicity, poor bioavailability and low water-solubility of many current drugs. The utilisation of palm oil as part of the drug delivery system seemed to improve the bioavailability and solubility of the drug, stabilising emulsification of formulation between emulsifier and surfactant, promoting enhanced drug permeability and performance, as well as extending the shelf-life of the drug. Despite the complexity in designing lipid-based formulations, palm oil has proven to offer dynamic behaviour in providing versatility in drug design, form and delivery. However, the knowledge and application of palm oil and its fractions in lipid-based formulation are scarce and interspersed. Therefore, this study aims to focus on the research and outcomes of using palm oil in lipid-based formulations and drug delivery systems, due to the importance of establishing its capabilities and benefits.

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Section: Drug Delivery System Of a Lipid-based Formulation Using Psupporting

confidence: 60%

Section: Drug Delivery System Of a Lipid-based Formulation Using Pmentioning

confidence: 99%

Palm Oil in Lipid-Based Formulations and Drug Delivery Systems

Goon¹,

Kadir²,

Latip³

et al. 2019

Biomolecules

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“…In other words, the SNEDDS formulated from blends of a homolipid from Capra hircus remained isotropic after drug loading. This uniform structure is necessary to avoid postformulation drug partitioning upon phase separation [28]. Based on this assessment alone, preference should be given to ratios with lower surfactant concentrations to avoid adverse effects due to use of surfactant at high concentrations.…”

Section: Resultsmentioning

confidence: 99%

Development and Evaluation of Novel Self-Nanoemulsifying Drug Delivery Systems Based on a Homolipid from Capra hircus and Its Admixtures with Melon Oil for the Delivery of Indomethacin

Obitte

Ofokansi

Kenechukwu

2014

Journal of Pharmaceutics

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In this study, goat fat (Capra hircus) and melon oil were extracted and used to formulate self-nanoemulsifying drug delivery systems (SNEDDS) based on either goat fat alone or its admixture with melon oil by employing escalating ratios of oil(s), surfactant blend (1 : 1 Tween 60 and Tween 80), and cosurfactant (Span 85), with or without carbosil, a glidant, for the delivery of indomethacin. The formulations were encapsulated in hard gelatin capsules and then assessed using isotropicity test, aqueous dilution stability and precipitation propensity, absolute drug content, emulsification time, in vitro drug release, and anti-inflammatory activity. The SNEDDS exhibited low precipitation propensity and excellent stability on copious dilution, as well as high drug release in vitro and in vivo. The inhibition produced by the SNEDDS was comparable to that of indomethacin injection (positive control) for much of the 5 h test period, indicating a high degree of bioavailability of the administered SNEDDS. The absolute drug contents and emulsification times fell within narrow limits. This study has shown that a 1 : 1 ratio of melon oil and goat fat could confer favourable properties with respect to drug release and anti-inflammatory activity on SNEDDS for the delivery of indomethacin, thus encouraging further development of the formulations.

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“…The oil was bleached and deodorized using activated charcoal as reported in Obite et al [14]. A 2 %w/w mixture of activated charcoal and oil was heated in a beaker at 90 °C for one hour.…”

Section: Bleaching and Deodorization Of The Oilmentioning

confidence: 99%

African Breadfruit Seed Oil as Lipid Phase of Self-Emulsifying Drug Delivery System for Improved Gastrointestinal Fluid Solubility of Ibuprofen: Design and Evaluation

Omeh,

Momoh,

Asogwa

et al. 2024

AJOCS

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Introduction: Rain forest vegetations all over the world produce large quantity of economically important seed oils which, in most developing countries are utilized only as food condiments but hardly employed in pharmaceutical formulations. Objectives: The purpose of this work was to formulate ibuprofen-loaded self-emulsifying drug delivery system for the enhancement of the gastrointestinal fluid solubility of this poorly water soluble drug. Methods: The breadfruit seed oil was extracted by the soxhlet extraction technique and characterized for various physicochemical properties including acid, iodine, peroxide, saponification values and organoleptic properties. The super saturation solubility process, water titration studies and pseudo ternary phase diagrams were used to select and quantify the components of the emulsion systems. The liquid self-emulsifying drug delivery systems were converted to solid forms by adsorption onto a blend of miceocrystalline cellulose and Aerosil-200 powders. The resulting wet mass was dried and processed for encapsulation. Results: The percentage yield of the oil from the extraction process was 20.68 % while the acid, iodine, and saponification values were, 4.12 ± 1.24, 21.91 ± 0.88, and 302.45 ± 1.22 respectively. The ibuprofen exhibited higher solubility in the hydrolysed oil than in the crude form. Fourier transform infrared analysis did not reveal existence of component incompatibility. The optimized liquid and solid emulsions exhibited standard characteristics that were compatible to previous literature reports. The formulations also exhibited superior drug release properties over two control samples. Conclusion: It was concluded that Breadfruit seed oil has the potential to function as the lipid component of ibuprofen-loaded self-emulsifying drug delivery system formulated to enhance the aqueous solubility of the drug.

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Preliminary Studies on Two Vegetable Oil Based Self Emulsifying Drug Delivery System (SEDDS) for the Delivery of Metronidazole, A Poorly Water Soluble Drug

Cited by 9 publications

References 19 publications

Palm Oil in Lipid-Based Formulations and Drug Delivery Systems

Palm Oil in Lipid-Based Formulations and Drug Delivery Systems

Development and Evaluation of Novel Self-Nanoemulsifying Drug Delivery Systems Based on a Homolipid from Capra hircus and Its Admixtures with Melon Oil for the Delivery of Indomethacin

African Breadfruit Seed Oil as Lipid Phase of Self-Emulsifying Drug Delivery System for Improved Gastrointestinal Fluid Solubility of Ibuprofen: Design and Evaluation

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