Preliminary study in specific activity of molecular components in allergy: implications for diagnostics and relationship with disease severity

S, Kos; Sanders, Robert-Jan; Neele, Marjolein; O'Sullivan, N l; Ruikes-Mertens, Sanne; Phaff, Rita A.S.

doi:10.1515/cclm-2016-0726

Cited by 4 publications

(7 citation statements)

References 11 publications

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“…The smallest study examined 104 participants, 41 while the largest sample consisted of 2741 individuals. 40 Three studies used ImmunoCAP, 38 , 39 , 40 with one 40 using both the conventional 32 cut‐off of 0.35 kUA/l and the lower cut‐off of 0.1 kUA/l, while the two other studies 38 , 39 only used 0.35 kUA/l. The two remaining studies 41 , 42 used ISAC, and the conventional 32 cut‐off of 0.3 ISU.…”

Section: Resultsmentioning

confidence: 99%

“… 40 Three studies used ImmunoCAP, 38 , 39 , 40 with one 40 using both the conventional 32 cut‐off of 0.35 kUA/l and the lower cut‐off of 0.1 kUA/l, while the two other studies 38 , 39 only used 0.35 kUA/l. The two remaining studies 41 , 42 used ISAC, and the conventional 32 cut‐off of 0.3 ISU. Further details of the included studies are found in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The results were narratively synthesized. For consistency, data in the synthesis were limited to measurements with the conventional 32 , 33 , 34 cut‐off values of 0.35 kUA/l for ImmunoCAP and 0.3 ISU for ISAC. Meta‐analysis was not possible to perform, given the insufficient and disparate data.…”

Section: Methodsmentioning

confidence: 99%

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Prevalence of sensitization to molecular food allergens in Europe: A systematic review

Lisik

Ioannidou

Spolidoro

et al. 2022

Clinical & Translational All

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Background Recent reports indicate that the prevalence of food allergy is increasing, but accurate estimates remain a challenge due to cross‐reactivity and limited use of precise diagnostic methods. Molecular allergy diagnostics, in which sensitization to individual molecular allergens is measured, is emerging as a promising tool for evaluation of sensitization profiles. In this systematic review, we summarized estimates of prevalence of sensitization to molecular food allergens in the general population in Europe. Methods Following a protocol prospectively registered with the International Prospective Register of Systematic Reviews (PROSPERO; reference CRD42021266657), we searched seven databases with no restrictions on publication date or language. Two reviewers independently screened the literature, extracted data, and appraised the risk of bias in the included studies. The findings were synthesized narratively. Results From 4776 de‐duplicated records, five studies, with low to moderate overall risk of bias, were included. Forty‐six molecular allergens from 18 foods were investigated. Overall, the prevalence of sensitization was low, particularly for major allergens, and non‐existent for 10 molecular allergens (0% [95% CI 0–0.8]). The highest prevalence was seen for PR‐10 proteins, such as Cor a 1.04 (13.6% [95% CI 10.9–16.9]). Conclusions Available data, primarily from North‐western Europe, indicate that sensitization to molecular food allergens is overall low. The highest estimates were found for cross‐reactive PR‐10 proteins. There were not enough studies to discern regional differences or perform meta‐analysis, highlighting the need for more population‐representative studies in order to elucidate patterns of sensitization to molecular food allergens in Europe.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Prevalence of sensitization to molecular food allergens in Europe: A systematic review

Lisik

Ioannidou

Spolidoro

et al. 2022

Clinical & Translational All

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“…There was, however, improved correlation between disease severity and clinical outcome with the use of SA MC as a clinical predictor compared to sIgE measurement. 22…”

Section: Specific Activity Of Molecular Componentsmentioning

confidence: 99%

Challenges in Allergy Diagnostics and Solutions Worth Considering

Sanders

2018

EMJ Allergy Immunol

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The introduction of molecular components has led to exponential growth in the field of allergy diagnosis over the last two decades and allergy testing is now more complex and comprehensive. Most specialists who do not deal with the management of allergy patients on a daily basis may find it difficult to stay up-to-date with current developments in the field, which, in practice, may lead to unnecessary or nontargeted testing. The primary objective of this review is to briefly summarise the major differences in past immunoglobulin E testing compared to modern methods. The secondary objective is to give an overview of approaches that are, in the authors’ opinions, worth considering as concepts because they address two fundamental issues in allergy management: how to relate results of immunoglobulin E testing to severity of symptoms, and how to increase the pretest probability of an allergy and facilitate management of an allergic patient.

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“…A maioria das condições alérgicas é frequentemente subdiagnosticada, e este desconhecimento a respeito do quadro clinico do paciente alérgico, se torna um obstáculo inicial à escolha da medicação para tratamentos. Neste sentido, muitas pessoas vivem com limitação da qualidade de vida e não recebem o tratamento adequado (DENNIS et al, 2004, CARABALLO et al, 2016 (PEREIRA et al, 2005;ECKMAN et al, 2009;VALERIO et al, 2015 (CANONICA et al, 2013, LUPINEK et al, 2014, KOS et al, 2017…”

Section: Diagnóstico Da Alergiaunclassified

Desenvolvimento de imunoensaio para detecção de IgG4 específico ao alérgeno rBlo t 5 e tratamento de modelo experimental na asma aguda

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Preliminary study in specific activity of molecular components in allergy: implications for diagnostics and relationship with disease severity

Cited by 4 publications

References 11 publications

Prevalence of sensitization to molecular food allergens in Europe: A systematic review

Prevalence of sensitization to molecular food allergens in Europe: A systematic review

Challenges in Allergy Diagnostics and Solutions Worth Considering

Desenvolvimento de imunoensaio para detecção de IgG4 específico ao alérgeno rBlo t 5 e tratamento de modelo experimental na asma aguda

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