Preliminary study of personality traits in Chinese lung cancer patients: Modification by neurotensin receptor 1 polymorphisms

Ma, Hongyu; Cong, Zhengtu; Zhang, Hongyu; Tao, Jiangang; Yang, Chao; Song, Zhijie

doi:10.1111/appy.12268

Cited by 2 publications

(4 citation statements)

References 6 publications

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“…Amplification of gene fragments containing the SNPs rs6090453, rs6011914, and rs2427422 by polymerase chain reaction and subsequent identification of genotypes by restriction fragment length polymorphism analysis were carried out as described in our previous studies ( 22 , 34 – 38 ).…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, the genes of the NT system may contribute to defense mechanisms by regulating dopamine neurotransmission. Moreover, our team has already demonstrated an association between NTR1 gene single nucleotide polymorphisms (SNPs) and personality traits assessed by the Tridimensional Personality Questionnaire (TPQ) in Chinese Han subjects ( 22 , 34 ). Therefore, we decided to test the hypothesis that the NTR1 SNPs were associated with defenses.…”

Section: Introductionmentioning

confidence: 99%

“…The results would provide empirical evidence for the biological factors of defense mechanism. The three SNPs investigated (rs6090453, rs6011914, and rs2427422, Figure 1 ) were selected due to our previous research on personality traits ( 22 , 34 ), copying styles ( 35 ), anxiety ( 36 ), schizophrenia ( 37 ), and alcohol dependence ( 38 ).…”

Section: Introductionmentioning

confidence: 99%

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Association of Neurotensin Receptor 1 Gene Polymorphisms With Defense Mechanisms in Healthy Chinese

Zhang³

et al. 2021

Front. Psychiatry

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Aims: In the central nerve system, neurotensin (NT), and neurotensin receptor 1 (NTR1) modulate the dopamine system. Gene variations in the dopamine system have been demonstrated to influence certain defense mechanisms, but no studies have investigated possible effect of NTR1 gene polymorphisms in the biological determination of these defenses. The present study therefore examined this link.Methods: In 412 healthy Han Chinese, single nucleotide polymorphisms rs6090453C/G, rs6011914C/G, and rs2427422A/G of the NTR1 gene were genotyped, and the defense mechanisms were measured by the self-reporting Defense Style Questionnaire 88.Results: Significant male-specific differences in the projective identification among the rs6090453 genotypes (p = 0.003); in the intermediate defense, reaction formation, and projective identification among the rs6011914 genotypes (p = 0.011, 0.010, and 0.011, respectively); and in the projective identification among the rs2427422 genotypes (p = 0.005) were found when the level of significance was adjusted by the Bonferroni correction. There was no significant difference in any of the defense scores among genotypes of any single nucleotide polymorphism in the total cohort or female subjects (all p > 0.017). The distributions of genotypes between the low and high score subgroups showed significant differences in the rs2427422 genotype distributions for help-rejecting complaining, regression, and projective identification (p = 0.010, 0.022, and 0.044, respectively). Significant differences were found between males and females in 10 defense mechanisms (all P < 0.05).Conclusions: The gene variations in the NTR1 polymorphisms were involved in the biological mechanisms of intermediate defense mechanisms, and this effect was influenced by sex.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of Neurotensin Receptor 1 Gene Polymorphisms With Defense Mechanisms in Healthy Chinese

Zhang³

et al. 2021

Front. Psychiatry

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“…22,[24][25][26][27] In this framework, individual personality plays an important role as well. [28][29][30] Personality refers to an individual's enduring and pervasive personal motivation, emotion, interpersonal style, attitudes, and behaviors that are stable over a long time after young adulthood. In relation to cancer, the personality traits have already been investigated.…”

Section: Introductionmentioning

confidence: 99%

Personality (at Intrapsychic and Interpersonal Level) Associated With Quality of Life in Patients With Cancer (Lung and Colon)

et al. 2019

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The objective of this study was to determine the association of quality of life (QoL) and intrapsychic and interpersonal behaviors (Structural Analysis of Social Behavior [SASB]) of patients with cancer (lung: n = 88; age 62.8 ± 10.1; colon: n = 56; age 60.1 ± 11.4). Personality described by SASB clusters (Cls): SASB-Questionnaire; QoL tests: FACT_G and QLQ-C30. Patients with lung cancer (n = 88; age 62.8 ± 10.1) and colon cancer (n = 56; age 60.1 ± 11.4; all stages of severity). Multiple regression analyses. Multiple linear regression: dependent variable: FACT_G; covariates: physical functioning, cognitive functioning, SASB-Cl3-50°, SASB-Cl6-50°. Analysis of variance and t test confirm validity of the model ( P < .001). SASB-Cl3 with FACT_G ( P = .034); SASB-Cl6 with FACT_G ( P = .002); age with FACT_G ( P = .018); physical functioning with FACT_G ( P < .001); cognitive functioning with FACT_G ( P < .001). Personality traits such as self-critical and oppressive behaviors, low capacity for self-esteem, physical and cognitive functioning, and age (a higher age determines a better QoL) strongly determine QoL in patients with lung and colon cancer. This may suggest areas of therapeutic intervention.

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Preliminary study of personality traits in Chinese lung cancer patients: Modification by neurotensin receptor 1 polymorphisms

Cited by 2 publications

References 6 publications

Association of Neurotensin Receptor 1 Gene Polymorphisms With Defense Mechanisms in Healthy Chinese

Association of Neurotensin Receptor 1 Gene Polymorphisms With Defense Mechanisms in Healthy Chinese

Personality (at Intrapsychic and Interpersonal Level) Associated With Quality of Life in Patients With Cancer (Lung and Colon)

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