Preliminary study on pre-treatment physical activity and quality of life in infertility

Prémusz, Viktória; Makai, Alexandra; Gács, Boróka; Nagy, Á.; Perjés, Beatrix; Ács, Pongrác; Lampek, Kinga; Várnagy, Ákos

doi:10.31382/eqol.191201

Cited by 5 publications

(6 citation statements)

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“…For the purpose of measuring the level of infertility-related stress, FPI was applied and moderately high Global stress (183.33 ± 28.19) was explored. In the five domains of the questionnaire we found similar values as in the pilot study [ 71 ]. Average stress by Rejection of childfree lifestyle (23.25 ± 6.04), moderately high stress by Social concern (41.40 ± 9.84) and very high stress level by Sexual- (38.62 ± 7.77) and by Relationship concern (48.53 ± 9.68).…”

Section: Resultssupporting

confidence: 83%

Multicausal analysis on psychosocial and lifestyle factors among patients undergoing assisted reproductive therapy – with special regard to self-reported and objective measures of pre-treatment habitual physical activity

et al. 2021

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Background National, regional and global trends in prevalence of infertility indicate its public health importance, however it effects various life dimensions of individuals and couples as well. Lifestyle habits may counteract with these factors. The aim of the study was the multicausal analysis of psychosocial and lifestyle factors undergoing assisted reproductive therapy (ART) with special regard to pre-treatment habitual physical activity (PA). Methods In a cross-sectional, observational cohort study on ART patients (N = 60, age 34.6 ± 5.2 years, BMI 24.2 ± 4.9 kg/m2) with follow up on outcome measures a detailed description was given on PA patterns (ActriGraph GT3X, GPAQ-H) and on general and infertility related distress (BDI-13, FPI). Results Respondents reported normal mood state (BDI-13) but moderately high infertility-related distress (FPI) in Social- and very high distress in Sexual Concern. It was revealed that time spent with recreational PA (RPA) could counteract with infertility-related distress (Social Concern R = -0.378, p = 0.013; Relationship Concern R = -0.365, p = 0.019). In the presence of clinical pregnancy GPAQ-H RPA MET was significantly higher (p = 0.048), in the non-pregnant group cumulative values and work-related PA were higher. Correlations could be found between RPA time and the number of oocytes (R = 0.315, p = 0.045), matured oocytes (R = 0.339, p = 0.030) and embryos (R = 0.294, p = 0.062) by women who reached at least 150 min RPA (GPAQ-H). Multivariate linear regression revealed that the number of oocytes was positively influenced by the GPAQ-H recreation MET (R2 = 0.367; F = 10.994, p = 0.004; B = 0.005, p = 0.004, B Constant = 4.604). Regarding the number of embryos (R2 = 0.757, F = 17.692, p < 0.001, B Constant = 1.342) positive relationship was found with GPAQ-H RPA MET (B = 0.004, p < 0.001) and negative with BMI (B = -0.167, p = 0.038). It was disclosed (R2 = 0.958, F = 408.479, p < 0.001) that higher Very Vigorous Activity (ActiGraph) was accompanied with higher hCG (B = 63.703, p ≤ 0.001). However, time spent with moderate PA (GPAQ-H) (B = 0.002, SE = 0.001, Wald = 3.944, p = 0.047, OR = 1.002) was significantly associated with live births. Conclusions Amount of PA alone did not have a positive effect on outcome of ART. Type and intensity seemed to be more significant. Existing differences in response to infertility due to recreational PA suggest the importance of the development of a specific intervention. The robust overestimation of PA in self-reports highlights the need to improve physical literacy of women undergoing ART.

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Section: Resultssupporting

confidence: 83%

Multicausal analysis on psychosocial and lifestyle factors among patients undergoing assisted reproductive therapy – with special regard to self-reported and objective measures of pre-treatment habitual physical activity

et al. 2021

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“…In our study, a cross-sectional design was used, and a fertility-specific scale, the FertiQoL, was applied for concurrent validity, which is one of the most frequently used scales to examine psychometric properties of infertility-specific patient-reported outcomes [ 22 ] besides the Fertility Problem Inventory (FPI) [ 66 ] and Copenhagen Multicentre Psychosocial Infertility-fertility Problem Stress Scale (COMPI-FPSS) [ 70 ]. There was already research experience using FertiQoL [ 26 , 30 ], FPI [ 27 , 29 ], and COMPI-FPSS [ 67 ] in the Hungarian sample.…”

Section: Discussionmentioning

confidence: 99%

“…Fertility-related quality of life (QoL) was measured with the Hungarian version of the Fertility Quality of Life Questionnaire (FertiQoL) [ 28 , 30 , 47 , 48 ]. FertiQoL is an internationally validated instrument to measure QoL in individuals experiencing fertility problems in diverse life areas.…”

Section: Methodsmentioning

confidence: 99%

“…In Hungary, some studies were conducted about the psychosocial burden [ 26 , 27 , 28 , 29 ] and lifestyle habits [ 29 , 30 , 31 ] of ART patients, but their main focus was on the prognostic value of outcome measures. The psychosocial care of ART patients in Hungary is only sporadically solved; there is no routine screening for early vulnerability detection.…”

Section: Introductionmentioning

confidence: 99%

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Introducing the Hungarian Version of the SCREENIVF Tool into the Clinical Routine Screening of Emotional Maladjustment

Prémusz

Ács

Bódis

et al. 2022

IJERPH

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Examining possible psychosocial maladjustments should be an integral part of fertility care. For the early detection of vulnerability, the present study aimed to adapt and test the reliability and validity of the Hungarian version of SCREENIVF against the Fertility Quality of Life Questionnaire (FertiQoL) in a cross-sectional on subfertile women (n = 60, age 34.6 ± 5.2 years, BMI 24.2 ± 4.9 kg/m2) at a university linked fertility clinic in South-Hungary. A confirmatory factor analysis (CFA) was conducted to investigate the construct validity. For the reliability testing, Cronbach alpha values were calculated. Spearman’s rank correlation tested the criterion validity. Discriminant validity was applied using Mann–Whitney U-test and Kruskal–Wallis test. The Edinburgh Framework and COSMIN checklist were applicable for the analysis using SPSS 27.0; significance was set at p < 0.05. The confirmatory factor analysis indicated a good fit; all dimensions were reliable (α ≥ 0.70). Cronbach’s alpha was excellent (0.825–0.904). Strong correlations were found between the total scale (FertiQoL) and anxiety (R = −0.507, p < 0.001), depression (R = 0.554, p < 0.001), and helplessness cognitions (R = −0.747, p < 0.001) and moderate or no correlation with acceptance cognitions (R = 0.317, p = 0.015) and social support (R = 0.230, p = 0.082). The Hungarian version of SCREENIVF proved a valid and reliable tool to measure psychological maladjustment before ART. A longitudinal, randomized, controlled trial involving the partners could further strengthen the results, which is among our long-term plans.

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“…The incidence of assisted reproductive therapies is increasing, but their success rates have not risen significantly in the last decade, which highlights the need for a detailed examination of lifestyle covariates, especially physical activity [ 51 , 52 ]. Our previous cohort study, [ 53 ] with a follow-up of primary and secondary outcomes [ 54 ], suggests that an abundance of pretreatment PA may support the course of IVF/ICSI and increase its success rate. Similar to the current study, a significant positive relationship with reproductive potential could only be described in women who achieved at least 150 min of recreational type of PA.…”

Section: Discussionmentioning

confidence: 99%

Pre-Treatment Physical Activity Could Positively Influence Pregnancy Rates in IVF despite the Induced Oxidative Stress: A Cohort Study on Salivary 8-Hydroxy-2′-deoxyguanosine

et al. 2022

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(1) Background: This study was designed to define whether pretreatment habitual physical activity (PA)-induced oxidative stress (OS) influences outcome measures by using 8-hydroxy-2′-deoxyguanosine (8-OHdG) in saliva samples of patients undergoing in vitro fertilization (IVF). (2) Method: In this cohort study, samples were obtained from 26 patients (age: 34.6 ± 5.5 years, BMI: 25.3 ± 5.1, infertility: 51.0 ± 28.7 months) before the treatment and a follow-up of outcome measures of IVF/ICSI. The 8-OHdG was evaluated by Abcam’s ELISA (ab201734), PA patterns by GPAQ-H and ActiGraph GT3X; (3) Results: The number of matured oocytes was positively influenced by the GPAQ-H recreation MET (R2 = 0.367, F = 10.994, p = 0.004; β = 0.005, p = 0.004, B Constant = 4.604) and a positive significant relationship (R2 = 0.757, F = 17.692, p < 0.001, B Constant = 1.342) was found with GPAQ-H recreational PA MET (β = 0.004, p < 0.001), and Grade 1 embryos and higher very vigorous activity (GT3X) were accompanied (R2 = 0.958, F = 408.479, p < 0.001) by higher ß-hCG levels (β = 63.703, p ≤ 0.001). Unanticipated positive correlation between 8-OHdG and ß-hCG level (R = 0.467, p = 0.028) was noticed, and there were significant differences in 8-OHdG in biochemical pregnancies (pregnant: 54.82 ± 35.56 ng/mL, non-pregnant: 30.06 ± 10.40 ng/mL, p = 0.022) as well. (4) Conclusions: Pretreatment PA could positively influence reproductive performance in IVF/ICSI despite the induced OS. However, a more sensitive biomarker and the recommended amount of activity should be further investigated.

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Preliminary study on pre-treatment physical activity and quality of life in infertility

Cited by 5 publications

References 19 publications

Multicausal analysis on psychosocial and lifestyle factors among patients undergoing assisted reproductive therapy – with special regard to self-reported and objective measures of pre-treatment habitual physical activity

Multicausal analysis on psychosocial and lifestyle factors among patients undergoing assisted reproductive therapy – with special regard to self-reported and objective measures of pre-treatment habitual physical activity

Introducing the Hungarian Version of the SCREENIVF Tool into the Clinical Routine Screening of Emotional Maladjustment

Pre-Treatment Physical Activity Could Positively Influence Pregnancy Rates in IVF despite the Induced Oxidative Stress: A Cohort Study on Salivary 8-Hydroxy-2′-deoxyguanosine

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