Preliminary study on the distribution of selected elements in cancerous and non-cancerous kidney tissues

Kwiatek, Wojciech M.; Drewniak, Tomasz; Gajda, Mariusz; Gałka, Marek; Hanson, A.L.; Cichocki, T

doi:10.1016/s0946-672x(02)80018-9

Cited by 29 publications

(29 citation statements)

References 11 publications

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“…Information about concentration levels of trace elements in cancerous and non-cancerous tissue [15] may verify the hypothesis about influence of trace elements on cancer disease in human population.…”

Section: Discussionmentioning

confidence: 88%

Cancerous tissues analyzed by SRIXE

Kwiatek

Banaś

Gajda

et al. 2005

Journal of Alloys and Compounds

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Section: Discussionmentioning

confidence: 88%

Cancerous tissues analyzed by SRIXE

Kwiatek

Banaś

Gajda

et al. 2005

Journal of Alloys and Compounds

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“…The same study also observed that there was no variation of Cl, Cr, Mn, Cu, Br, and Pb between carcinoma tissues and the normal tissues. A different study, however, reported lower concentration of Cd, Cr, Ti, V, Cu, and Zn in cancerous kidney tissue than the noncancerous in the analysis, a fact this study attributed to the different metabolism and dynamics of cancer process compared to normal tissue [41]. Potassium being a major intracellular cation was observed to be in low concentration in carcinoma tissue than in normal tissue.…”

Section: Trace Metal Concentrations In Human Tissuesmentioning

confidence: 85%

Comparative Trace Elemental Analysis in Cancerous and Noncancerous Human Tissues Using PIXE

Mulware

2013

Journal of Biophysics

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The effect of high or low levels of trace metals in human tissues has been studied widely. There have been detectable significant variations in the concentrations of trace metals in normal and cancerous tissues suggesting that these variations could be a causative factor to various cancers. Even though essential trace metals play an important role such as stabilizers, enzyme cofactors, elements of structure, and essential elements for normal hormonal functions, their imbalanced toxic effects contribute to the rate of the reactive oxygen species (ROS) and formation of complexities in the body cells which may lead to DNA damage. The induction of oxidative-induced DNA damage by ROS may lead to isolated base lesions or single-strand breaks, complex lesions like double-strand breaks, and some oxidative generated clustered DNA lesions (OCDLs) which are linked to cell apoptosis and mutagenesis. The difference in published works on the level of variations of trace metals in different cancer tissues can be attributed to the accuracy of the analytical techniques, sample preparation methods, and inability of taking uniform samples from the affected tissues. This paper reviews comparative trace elemental concentrations of cancerous and noncancerous tissues using PIXE that has been reported in the published literature.

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“…Margalioth and coworkers [72] reported that the increase observed in copper level of cancerous kidney when compared to normal kidney tissues was found to be statistically insignificant, whereas the decrease observed in Zn concentration of the same kidney samples was found to be markedly significant (-73%). On the other hand, Kwiatek and coworkers [46] observed that the concentrations of metals such as Cd, Cr, Ti, V, Cu, Zn and Se except Fe were lower in the cancerous parts of the kidney samples in comparison with the non-cancerous parts and with the controls. The same authors described that this fact might be attributed to the different metabolism and dynamics of the cancer process, in compared to normal tissue.…”

Section: Kidneymentioning

confidence: 93%

Comprehensive Comparison of Trace Metal Concentrations in Cancerous and Non-Cancerous Human Tissues

Yaman

2006

CMC

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The roles of metals in the development and inhibition of cancer have a complex character and have risen many questions because of their essential and toxic effects on human health. Question of whether trace metal concentrations in tissues are increased or decreased in cancerous patients in comparison with non-cancerous patients has not been answered yet, due to the fact that the data known in this field is rare and have contradictory results. Although Zn and Cu concentrations in serum and tissues of cancerous patients have been extensively studied, the precise role of these metals in carcinogenesis is not clearly understood. On the other hand, the comprehensive review on trace metal concentrations in cancerous and non-cancerous tissues is uncommon. The differences in literature on the increases or decreases in trace metal concentrations of cancerous tissues in comparison with non-cancerous tissues may be attributed to a few reasons such as the tissue basis-dry or wet weight, different sensitivities and basis of analysis methods that affect the accuracy, and the difficulties in taking of the sample representing the cancerous or non-cancerous area. In this study, the data published up to now have been reviewed. Comparison of results was done according to tissue and cancer types and trace metal species. The probable causes of differences in literature data were discussed. Especially, the published studies in recent years needed such a review.

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Preliminary study on the distribution of selected elements in cancerous and non-cancerous kidney tissues

Cited by 29 publications

References 11 publications

Cancerous tissues analyzed by SRIXE

Cancerous tissues analyzed by SRIXE

Comparative Trace Elemental Analysis in Cancerous and Noncancerous Human Tissues Using PIXE

Comprehensive Comparison of Trace Metal Concentrations in Cancerous and Non-Cancerous Human Tissues

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