Preliminary study on the effect of brazilin on biofilms of Staphylococcus aureus

Peng, Dan; Chen, Anlin; Shu, Bin; Min, Xun; Zhang, Tao; Dong, Zehua; Yang, Huan; Chen, Xianlian; Tian, Yuan; Chen, Zehui

doi:10.3892/etm.2018.6403

Cited by 6 publications

(7 citation statements)

References 45 publications

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“…Brazilin, isolated from Caesalpinia sappan L, suppresses the biofilm formation and destroys biofilm of S. aureus possibly by inhibiting extracellular polysaccharide secretion via modulation of icaA and icaR . Moreover, extracts of wheat bran and Brazilian peppertree also exhibit an inhibitory effect on biofilm formation by S.…”

Section: Biofilm Formationmentioning

confidence: 99%

Natural Products That Target Virulence Factors in Antibiotic-Resistant Staphylococcus aureus

Liu

Zhu

et al. 2019

J. Agric. Food Chem.

116

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The increase in the incidence of antibiotic-resistant Staphylococcus aureus (S. aureus) associated infections necessitates the urgent development of novel therapeutic strategies and antibacterial drugs. Antivirulence strategy is an especially compelling alternative strategy due to its low selective pressure for the development of drug resistance in bacteria. Plants and microorganisms are not only important food and medicinal resources but also serve as sources for the discovery of natural products that target bacterial virulence factors. This review discusses the mechanisms of the major virulence factors of S. aureus, including the accessory gene regulator quorum-sensing system, bacterial biofilm formation, α-hemolysin, sortase A, and staphyloxanthin. We also provide an overview of natural products isolated from plants and microorganisms with activity against the major virulence factors of S. aureus and their adjuvant effects on existing antibiotics to overcome antibiotic-resistant S. aureus. Finally, the limitations and solutions of these antivirulence compounds are discussed, which will help in the development of novel antibacterial drugs against antibiotic-resistant S. aureus.

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Section: Biofilm Formationmentioning

confidence: 99%

Natural Products That Target Virulence Factors in Antibiotic-Resistant Staphylococcus aureus

Liu

Zhu

et al. 2019

J. Agric. Food Chem.

116

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“…Several other plant-derived phenolic compounds have already been discussed in the work by Wu et al, including chalcone [106], resveratrol ( [107], phloretin [104], alfa-cyperone [87], curcumin [108], osthole [105], and brazilin [109]. Among these, resveratrol (Table 11) was active against α-hemolysin [107] and, used in combination with vancomycin, inhibited biofilm formation.…”

Section: Other Phenolic Compoundsmentioning

confidence: 99%

Plant Derived Natural Products against Pseudomonas aeruginosa and Staphylococcus aureus: Antibiofilm Activity and Molecular Mechanisms

et al. 2020

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Bacteria are social organisms able to build complex structures, such as biofilms, that are highly organized surface-associated communities of microorganisms, encased within a self- produced extracellular matrix. Biofilm is commonly associated with many health problems since its formation increases resistance to antibiotics and antimicrobial agents, as in the case of Pseudomonas aeruginosa and Staphylococcus aureus, two human pathogens causing major concern. P. aeruginosa is responsible for severe nosocomial infections, the most frequent of which is ventilator-associated pneumonia, while S. aureus causes several problems, like skin infections, septic arthritis, and endocarditis, to name just a few. Literature data suggest that natural products from plants, bacteria, fungi, and marine organisms have proven to be effective as anti-biofilm agents, inhibiting the formation of the polymer matrix, suppressing cell adhesion and attachment, and decreasing the virulence factors’ production, thereby blocking the quorum sensing network. Here, we focus on plant derived chemicals, and provide an updated literature review on the anti-biofilm properties of terpenes, flavonoids, alkaloids, and phenolic compounds. Moreover, whenever information is available, we also report the mechanisms of action.

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“…Different studies demonstrated its multiple biological properties, including immune system modulatory, antioxidant, anti-inflammatory, antiplatelet, antihepatotoxicity, and antitumor activities [62], as well as its antimicrobial activity [63]. In 2018, Peng and collaborators used a biofilm model of S. aureus to establish in vitro inhibitory effects of brazilin on biofilm formation [19]. Indeed, this molecule was able to inhibit and destroy S. aureus biofilm, to reduce the production of the extracellular polymeric matrix and to inhibit the QS system, thus supporting its use as a novel drug and treatment strategy for S. aureus biofilm-associated infections [19].…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

“…In 2018, Peng and collaborators used a biofilm model of S. aureus to establish in vitro inhibitory effects of brazilin on biofilm formation [19]. Indeed, this molecule was able to inhibit and destroy S. aureus biofilm, to reduce the production of the extracellular polymeric matrix and to inhibit the QS system, thus supporting its use as a novel drug and treatment strategy for S. aureus biofilm-associated infections [19].…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

“…Since this QS-regulated trait is easily observable by disc diffusion assay, C. violaceum is widely used as biosensor strain for screening anti-QS molecules. More specific and targeted screening methods for anti-QS activity include biofilm formation and eradication assays by crystal violet staining [18,19,20], quantification of QS-regulated virulence traits (e.g., pyocyanin production in P. aeruginosa , alpha-hemolysin secretion by S. aureus , protease production) as well as gene expression analysis of known QS-targets [21,22].…”

Section: Introductionmentioning

confidence: 99%

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Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens

Scoffone

Trespidi

Chiarelli

et al. 2019

IJMS

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Cystic fibrosis (CF) is an autosomal recessive genetic disorder which leads to the secretion of a viscous mucus layer on the respiratory epithelium that facilitates colonization by various bacterial pathogens. The problem of drug resistance has been reported for all the species able to colonize the lung of CF patients, so alternative treatments are urgently needed. In this context, a valid approach is to investigate new natural and synthetic molecules for their ability to counteract alternative pathways, such as virulence regulating quorum sensing (QS). In this review we describe the pathogens most commonly associated with CF lung infections: Staphylococcus aureus, Pseudomonas aeruginosa, species of the Burkholderia cepacia complex and the emerging pathogens Stenotrophomonas maltophilia, Haemophilus influenzae and non-tuberculous Mycobacteria. For each bacterium, the QS system(s) and the molecules targeting the different components of this pathway are described. The amount of investigations published in the last five years clearly indicate the interest and the expectations on antivirulence therapy as an alternative to classical antibiotics.

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Preliminary study on the effect of brazilin on biofilms of Staphylococcus aureus

Cited by 6 publications

References 45 publications

Natural Products That Target Virulence Factors in Antibiotic-Resistant Staphylococcus aureus

Natural Products That Target Virulence Factors in Antibiotic-Resistant Staphylococcus aureus

Plant Derived Natural Products against Pseudomonas aeruginosa and Staphylococcus aureus: Antibiofilm Activity and Molecular Mechanisms

Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens

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