Premalignant and Early Squamous Cell Carcinoma

Butani, Anjali; Arbesfeld, David M.; Schwartz, Robert A.

doi:10.1016/j.cps.2006.03.001

Cited by 3 publications

(2 citation statements)

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“…These well‐known cosmeceutical actives can efficiently improve the signs of photoaged skin (e.g. xerosis, laxity, deep wrinkles, sebboroic keratoses, pigmented spots), including actinic keratoses, which are also considered to be pre‐malignant lesions . Nevertheless, the use of AHAs in dermatology and cosmetology is often limited because of the skin irritation promotion .…”

Section: Introductionmentioning

confidence: 99%

Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside‐based topical emulsions: the colloidal structure, stability and efficacy evaluation

Tasić‐Kostov

Pavlović

Lukić

et al. 2012

Intern J of Cosmetic Sci

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Cosmeceutical antioxidants may protect the skin against oxidative injury, involved in the pathogenesis of many skin disorders. However, an unsuitable topical delivery system with compromising safety profile can affect the efficacy of an antioxidant active. This study investigated the antioxidant potential of lactobionic acid (LA), a newer cosmeceutical active, per se (in solution) and incorporated into natural alkyl polyglucoside (APG) emulsifier-based system using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging and lipid peroxidation inhibition assays. The α-tocopherol was used as a reference compound. The physical stability (using rheology, polarization microscopy, pH and conductivity measurements) of an Alkyl glucoside-based emulsion was evaluated with and without the active (LA); colloidal structure was assessed using polarization and transmission electron microscopy, rheology, thermal and texture analysis. Additionally, the safety profile and moisturizing potential were investigated using the methods of skin bioengineering. Good physical stability and applicative characteristics were obtained although LA strongly influenced the colloidal structure of the vehicle. LA per se and in APG-based emulsion showed satisfying antioxidant activity that promotes it as mild multifunctional cosmeceutical efficient in the treatment and prevention of the photoaged skin. Employed assays were shown as suitable for the antioxidant activity evaluation of LA in APG-based emulsions, but not for α-tocopherol in the same vehicle.

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Section: Introductionmentioning

confidence: 99%

Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside‐based topical emulsions: the colloidal structure, stability and efficacy evaluation

Tasić‐Kostov

Pavlović

Lukić

et al. 2012

Intern J of Cosmetic Sci

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“…In Brazil, non‐melanoma skin cancer is the most prevalent neoplasm, 5 and AK is a common problem in the population, being one of the most common conditions treated by dermatologists. However, there are no reports concerning the rate of malignant transformation of AK lesions in the Brazilian population, with AK lesions generally being treated by the use of destructive modalities, such as cryosurgery and curettage 6 . On occasion, AK diagnosis may be difficult, particularly when evaluating small‐punch or superficial shave biopsies in which the overall global architectural pattern, including dermis section, of the lesion is not represented 7 …”

mentioning

confidence: 99%

Expression of apoptotic, cell proliferation regulatory, and structural proteins in actinic keratosis and their association with dermal elastosis

Silva¹,

Coelho²,

Bocca³

et al. 2007

J Cutan Pathol

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Borderline conditions in dermato-oncology

Seleznev

Tamrazova

Sergeev

et al. 2021

Medicinskij alfavit

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This review article provides an overview of the etiology, pathogenesis, clinical presentation, diagnosis, and treatment methods for actinic keratosis, keratoacanthoma, and Bowen’s disease. The provoking factors are described, where the main importance is attached to insolation, previous immunosuppression and immunodeficiency and trauma. The pathogenesis of these diseases is described in the form of cascade models. Various clinical forms and their main dermatoscopic features, suitable for digital processing in automated diagnostic systems, are presented. A stepwise approach to the treatment of these nosologies is described, and a preliminary prognosis is assessed based on the duration of progression and the likelihood of transformation into squamous cell carcinoma. Given the fact that dermato-oncologists have not yet come to a consensus on the classification of the described diseases, in this article they are considered as a borderline, thereby demonstrating a fine line of transition from a precancerous state to cancer in situ.

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Premalignant and Early Squamous Cell Carcinoma

Cited by 3 publications

References 0 publications

Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside‐based topical emulsions: the colloidal structure, stability and efficacy evaluation

Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside‐based topical emulsions: the colloidal structure, stability and efficacy evaluation

Expression of apoptotic, cell proliferation regulatory, and structural proteins in actinic keratosis and their association with dermal elastosis

Borderline conditions in dermato-oncology

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