Premalignant and Malignant Perianal Lesions

Abbass, Mohammad Ali; Valente, Michael

doi:10.1055/s-0039-1687835

Cited by 14 publications

(8 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Abbass and Valente [20] described the treatment algorithm of perianal margin SCC as follows: (i) WLE with 1 cm clear margin should be performed in T1N0 lesions (<2 cm) without anal sphincter invasion. (ii) T2N0 lesions (between 2 and 5 cm) without lymph node involvement can be treated with WLE.…”

Section: Discussionmentioning

confidence: 99%

“…(iii) Lymph node-positive patients or T3, T4 patients, should be treated with combined modality CRT as mentioned above, as well as radiotherapy, including the pelvis and bilateral inguinal lymph nodes. In our series, we applied an algorithm similar to that of Abbass and Valente [20] and we applied chemoradiotherapy to tumors larger than 5 cm. In addition, we added adjuvant therapy in cases with perineural invasion.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Squamous cell skin carcinoma due to chronic sacrococcygeal diseases

et al. 2022

View full text Add to dashboard Cite

Introduction/Objective. Sacrococcygeal region squamous cell cancers (SCC) due to chronic sacrococcygeal diseases of skin are rare malignancies. The anatomical relation with the anus represents a challenge for diagnosis and surgical treatment. The oncological treatment algorithm is still controversial. Here, we investigated the clinicopathologic features of skin cancer of the sacrococcygeal region in a total of 10 cases from a surgical oncology reference center. Methods. We retrospectively analyzed the patients who underwent surgery for sacrococcygeal region skin SCC between January 2010 and July 2020. Results. All patients were male, and the mean age was 52.9?10.5 years. In the etiology, five patients had hidradenitis suppurativa, 2 had Human papillomavirus associated condyloma (Buschke-Lowenstein tumor), and 3 had pilonidal sinus disease. The mean time between the development of the lesion and malignancy diagnosis was 21.7?5.8 years. In the preoperative evaluation, three patients had bone invasion. None of the patients had anal sphincter or rectal invasion. Also, no patient had lymph node metastasis or distant metastasis. Wide local excision (WLE) was performed in all patients; 3 of them with bone resection. Adjuvant chemoradiotherapy was applied to five patients. In a 28.5?13.7 months follow-up, local recurrence occurred in 5 patients and WLE has performed again in these patients. Of these 5 patients, 2 eventually became metastatic. Finally, 3 patients died due to disease and 6 patients are still free of diseases. Conclusion. Sacrococcygeal region SCCs may rarely develop after a long interval from hidradenitis suppurativa, pilonidal sinus disease, and condyloma acuminata. Anal sphincter-sparing WLE can be applied, but sphincter dysfunction may occur. The disease is associated with a high risk of relapse and poor survival.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Squamous cell skin carcinoma due to chronic sacrococcygeal diseases

et al. 2022

View full text Add to dashboard Cite

show abstract

“…There is an ongoing debate as to whether "very large" or giant condyloma are the same, different, or on a continuum with Buschke Löwenstein tumor. 1,11 The lack of a definition of GPC makes it difficult to determine its real incidence and to compare the results of different treatments. A review of the literature shows only case reports or small case series, 5,12,13 and one of the largest series, covering the period from 1999 to 2011, reported 9 consecutive patients (6 PLHIV) with GPC (the sizes of the GPCs were not reported) treated by wide local excision and anoplasty.…”

Section: Discussionmentioning

confidence: 99%

Giant Perianal Condyloma Successfully Treated with Podophyllin at 25% in Solid Petrolatum

López

Rosa

Cipollone

et al. 2021

Journal of Coloproctology

View full text Add to dashboard Cite

Purpose Giant perianal condyloma (GPC) is a rare condition. The effective treatment is a multidisciplinary challenge; topical treatments are usually ineffective, and surgical resection has significant morbidity. Podophyllin at 25% in solid petrolatum (25%PSP) can be an effective treatment option for GPC. The aim of the present study was to assess its response and tolerability. Methods This retrospective, single-center case series evaluated the clinical response of 14 patients with GPC treated with 25%PSP in a public hospital in Buenos Aires between December 2015 and December 2019. After obtaining a full history and performing a physical exam, the lesions were measured and photographed. Biopsies were performed to exclude malignancy, as well as exams to rule out pregnancy. Podophyllin at 25% in solid petrolatum was administered topically in cases of GPC and washed off by the patients at home after 4 hours. The patients underwent at least 4 weekly visits, which included interval history, photodocumentation of the lesions, and provider-applied 25%PSP. The response rate was assessed by comparing measurements and the overall decrease in volume of the GPC based on photos from the first and last sessions. Adverse outcomes were noted. Results In total, 10 men, 3 women, and 1 transgender woman with GPC unresponsive to prior treatments and a mean age of 34.5 years were included. A total of 12 patients were immunosuppressed. All the perianal lesions were circumferential and measured between 8 cm and 20 cm. Overall, 7 patients had genital condyloma outside of the anus and perianus; the histology showed low-grade squamous intraepithelial lesions in all cases. While on treatment, 7 patients reported dermatitis, and 71% of the patients had ≥ 75% reduction in lesion size. Conclusions Podophyllin at 25% in solid petrolatum is an effective, well-tolerated topical treatment option for GPC.

show abstract

“…The perianal region is the hair-bearing skin that lies within a 5 cm radius of the anal verge and is composed of keratinized squamous epithelium. Squamous cell carcinomas (SCCs) in this region are less common than those of the anal canal and can have more favourable outcomes if treated early [1].…”

Section: Dear Editormentioning

confidence: 99%

“…Treatment includes both surgery and chemoradiotherapy dependent on the size, staging and sphincter involvement. Smaller lesions with no sphincter or lymph node involvement can be treated with wide local excision; however, excision of larger lesions can lead to large tissue defects and the risk of faecal incontinence if there is involvement of the anal sphincter [1,4].…”

Section: Staging Of Perianal Scc Is Based Upon the American Jointmentioning

confidence: 99%