Premature Atherosclerosis Long After Kawasaki Disease

Noto, Nobutaka; Okada, Tomoo

doi:10.5772/32089

Cited by 1 publication

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although vasculitis can occur independently of T cell‐ and B cell‐mediated immunity, acquired immunity is undoubtedly associated with the vasculitides mediated by the innate immune system in humans. Regarding late KD vasculopathy and the premature development of atherosclerosis in patients with a prior history of KD , further studies are necessary to elucidate the mechanisms underlying these phenomena. They may result from persistent exposure to small amounts of vasculitis‐inducing molecules produced by endogenous microbes or from acquired immunity‐mediated vascular inflammation .…”

Section: Kd Aetiologymentioning

confidence: 99%

Kawasaki disease: a matter of innate immunity

Hara

Nakashima

Sakai

et al. 2016

Clinical and Experimental Immunology

120

125

View full text Add to dashboard Cite

SummaryKawasaki disease (KD) is an acute systemic vasculitis of childhood that does not have a known cause or aetiology. The epidemiological features (existence of epidemics, community outbreaks and seasonality), unique age distribution and clinical symptoms and signs of KD suggest that the disease is caused by one or more infectious environmental triggers. However, KD is not transmitted person-to-person and does not occur in clusters within households, schools or nurseries. KD is a self-limited illness that is not associated with the production of autoantibodies or the deposition of immune complexes, and it rarely recurs. Regarding the underlying pathophysiology of KD, innate immune activity (the inflammasome) is believed to play a role in the development of KD vasculitis, based on the results of studies with animal models and the clinical and laboratory findings of KD patients. Animal studies have demonstrated that innate immune pathogen-associated molecular patterns (PAMPs) can cause vasculitis independently of acquired immunity and have provided valuable insights regarding the underlying mechanisms of this phenomenon. To validate this concept, we recently searched for KD-specific PAMPs and identified such molecules with high specificity and sensitivity. These molecules have structures similar to those of microbe-associated molecular patterns (MAMPs), as shown by liquid chromatography-tandem mass spectrometry. We propose herein that KD is an innate immune disorder resulting from the exposure of a genetically predisposed individual to microbe-derived innate immune stimulants and that it is not a typical infectious disease.

show abstract

Section: Kd Aetiologymentioning

confidence: 99%