2021
DOI: 10.1371/journal.pone.0258851
|View full text |Cite
|
Sign up to set email alerts
|

Premature cognitive decline in specific domains found in young veterans with mTBI coincide with elder normative scores and advanced-age subjects with early-stage Parkinson’s disease

Abstract: Importance Epidemiologists report a 56% increased risk of veterans with (+) mild traumatic brain injury (mTBI) developing Parkinson’s disease (PD) within 12-years post-injury. The most relevant contributors to this high risk of PD in veterans (+) mTBI is unknown. As cognitive problems often precede PD diagnosis, identifying specific domains most involved with mTBI-related PD onset is critical. Objectives To discern which cognitive domains underlie the mTBI-PD risk relationship proposed in epidemiology studie… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

0
21
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
7
2

Relationship

3
6

Authors

Journals

citations
Cited by 16 publications
(21 citation statements)
references
References 45 publications
0
21
0
Order By: Relevance
“…Therefore, these studies establish a platform upon which to optimize mechanistic findings in Pink1 rat PD models for translation to the human PD patient. This would include the feasibility of initiating exercise when subclinical non-motor signs of PD may be present [ 85–89 ]. Finally, the Pink1 KO rat exhibits near 100% compliance at exercise intensities in the moderate range.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, these studies establish a platform upon which to optimize mechanistic findings in Pink1 rat PD models for translation to the human PD patient. This would include the feasibility of initiating exercise when subclinical non-motor signs of PD may be present [ 85–89 ]. Finally, the Pink1 KO rat exhibits near 100% compliance at exercise intensities in the moderate range.…”
Section: Discussionmentioning
confidence: 99%
“…Our study also shows DA loss paralleled severe TH loss in striatum, whereas in the SN, DA loss was much less and correlative with the magnitude of hypokinesia severity. These observations may be applicable to detecting PD in the prodromal period, wherein non-motor impairments, including specific executive function deficits [85] are underway during this period [14]. To this end, there was major DA loss in the nucleus accumbens, contrasting against increased DA in the VTA 7 days after lesion induction.…”
Section: Discussionmentioning
confidence: 99%
“…The Trail-Making Test (TMT) is a goal-directed task used to measure attention, cognitive flexibility, and working memory in humans [4,13]. Our primary goal was to explore whether a rodent task might detect premotor executive functioning deficits that would translate better to TMT outcomes in human PD than other animal testing paradigms [14][15].…”
Section: Introductionmentioning
confidence: 99%
“…Heavily restricting food intake to a degree where body mass is afffected could negatively impact cognition or drive some animals to seek the food reward more than others, thus adversely influencing the results [25]. Therefore, we administered an appetitive 5-T maze to 4-month-old PINK1 -/- rats with mitigated confounding variable to better reflect the premotor cognitive decline observed in early-stage PD human subjects [4, 19].…”
mentioning
confidence: 99%