Premature Hair Graying: A Probable Coronary Risk Factor

Gould, Lawrence; Reddy, C.V.R.; Oh, K.C.; Kim, S.G.; Becker, William H.

doi:10.1177/000331977802901103

Cited by 36 publications

(35 citation statements)

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“…In the present study there was a huge societal misconception that gray hair sufferers were older of their age. Similar findings were reported previously [17]. This fact has been reported to have a far-reaching effect to the sufferers in the society from social stigma to difficulties in getting spouses and marriage [2].…”

Section: Resultssupporting

confidence: 90%

“…The pattern of scalp regional graying development did not essentially differ between sexes but more males (75.5%) had hair graying initially involving the parietal areas than in the females whose regional graying patterns were mostly equally distributed all over the scalp regions. behaviors such as smoking and sedentary life style were reported by a huge proportion of participants [8,15,16] whereas some other studies established a weak association or no association at all [17]. The consequential psychological effects to the sufferers were enormous among the participants of the present study.…”

Section: Resultscontrasting

confidence: 58%

“…Loss of self-esteem and worries over a possibility of worse underlying metabolic conditions such as diabetes cholesterolemia, coronary artery disease and osteopenia affected a huge number of the participants. Several studies have reported results that indicate a putative association between PHG and other hidden ill-health conditions [1,11,18,19] whereas other findings have disputed this view [9,17]. This equivocal hypothesis of PHG as ill-health indicator calls for the need of more studies in order to devise possible preventative approaches if a positive association is firmly established.…”

Section: Resultsmentioning

confidence: 99%

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Premature Hair Graying: Profiling the Scalp Anatomical Patterns of Occurrence in Tanzania

Russa¹,

Haonga²,

Mboneko³

2017

IJAR

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Introduction: Premature hair graying (PHG) is a relatively common condition affecting up to 50% of the young people before age 30. Hair graying has adverse effects on self esteem, socio-cultural acceptance and may lead to social stigma and discrimination. Studies have linked PHG with a variety of underlying ill-health conditions such as myocardial infarction, cancer, osteopenia, stroke and cirrhosis. In Tanzania and indeed in Africa at large, PHG is rarely studied. The present study aimed to describe the pattern of onset and anatomical distribution of premature hair graying among the young adult sufferers.

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Section: Resultssupporting

confidence: 90%

Section: Resultscontrasting

confidence: 58%

Section: Resultsmentioning

confidence: 99%

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Premature Hair Graying: Profiling the Scalp Anatomical Patterns of Occurrence in Tanzania

Russa¹,

Haonga²,

Mboneko³

2017

IJAR

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“…Our findings also supported these observations and detailed them. Afterwards, subsequent studies with various sample sizes were performed in different patient populations including CAD, myocardial infarction in black or white men or women (5)(6)(7)(8)(9)(10)(11). Several of these reports also showed association between premature hair whitening and myocardial infarction, although many are relatively outdated and have some methodological limitations, especially in determining the extent of CAD and intensity of hair whitening.…”

Section: Discussionmentioning

confidence: 99%

The degree of premature hair graying as an independent risk marker for coronary artery disease: a predictor of biological age rather than chronological age

Kocaman

Çetin²,

Durakoğlugil³

et al. 2012

Anadolu Kardiyol Derg

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The degree of premature hair graying as an independent risk marker for coronary artery disease: a predictor of biological age rather than chronological ageKoroner arter hastalığı için bağımsız bir risk öngörücüsü olarak saçın erken beyazlama düzeyi: Zamansal yaştan çok biyolojik yaşın öngörücüsü ABSTRACTObjective: Age is the most important and uncorrectable coronary risk factor at the moment. The concept of measuring aging biologically rather than only chronologically may be of importance in clinical practice. Hair graying is the most apparent sign of biological aging in humans, yet its mechanism is largely unknown. Today, it is known that cardiovascular risk factors (CVRFs), especially in combination, cause premature atherosclerosis. In our opinion, premature hair graying or whitening may represent early atherosclerotic changes as a surrogate of host response to the CVRFs. In this study, we planned to investigate the relationship of hair graying with CVRFs and coronary atherosclerotic burden in order to determine whether it is an independent marker for coronary artery disease (CAD). Methods: The current study has a cross-sectional observational design. Two hundred and thirteen men who underwent coronary angiography with a suspicion of CAD were enrolled in the study. The patients were evaluated in terms of age, demographical properties and the CVRFs. Hair whitening score (HWS) was defined according to extent of gray/white hairs (1: pure black; 2: black>white; 3: black=white; 4: white>black; 5: pure white). Coronary atherosclerotic burden was assessed by the Gensini score. Analyses were performed in age-matched normal coronary arteries (NCA) and CAD groups. Linear and logistic regression analyses were used for the multivariate analyses of independent variables associated with hair greying. Results: The CVRFs were higher in CAD group. Hair whitening score (2.7±1.3 vs. 3.3±1.2, p=0.002), hair losing score (1.2±0.9 vs. 1.5±1.0, p=0.038) and xanthelasma rate (24% vs. 45%, p=0.013) were also significantly different between NCA and CAD groups. Age (p<0001), Gensini score (p<0.001) and coronary severity score (p=0.001) were higher in the categories of increased HWS. In multiple logistic regression analysis, only diabetes mellitus (OR: 3.240, 95% CI: [1.017-10.319], p=0.047), low-density lipoprotein cholesterol, (OR: 1.014, 95%CI: [1.001-1.027], p=0.029) and HWS (OR: 1.513, 95% CI: [1.054-2.173], p=0.025) were independently related to presence of CAD. Age (p<0.001), family history of CAD (p=0.004), hyperlipidemia (p=0.02) and serum creatinine levels (p=0.019) were found as independent predictors of hair graying. Conclusion: In our study, we found that the degree of gray/white hairs is related to extent of CAD. Our findings also suggested that hair graying is a risk marker for CAD independent of age and other traditional risk factors. Biological age may be important in determining total risk of patients. During assessment of cumulative CVRF effects on human body, presence of biological aging signs may be useful in identi...

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“…All of these pathological microenvironments can be produced by CVRFs (11), which can induce premature vascular aging and atherosclerosis. In prior studies, premature hair graying has also been reported to be associated with CVRFs (12)(13)(14)(15), CAD and myocardial infarction (16)(17)(18)(19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 97%

Premature Hair Whitening is an Independent Predictor of Carotid Intima-media Thickness in Young and Middle-aged Men

Kocaman¹,

Çetin²,

Durakoğlugil

et al. 2013

Intern. Med.

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Objective Premature graying or whitening of the hair may possibly represent premature atherosclerotic changes as a surrogate marker of different host responses to cardiovascular risk factors (CVRFs). This study was undertaken to test whether carotid artery intima-media thickness (CIMT) as a validated surrogate marker of the severity and extent of coronary artery disease (CAD) is higher in subjects with prominent signs of hair whitening, independent of chronological age and other CVRFs. Methods The current study was conducted in young and middle-aged patients (<55 years age) without a history of cardiovascular disease. Two hundred and two eligible patients consecutively admitted to our outpatient clinic for CVRF management were included. A gray/white-hair scale was used to determine the percentage of hair whitening. Results In the groups determined according to the degree of hair whitening, age (p<0.001), waist circumference (p=0.011), the presence of hypertension (p=0.003), the uric acid levels (p=0.008), the C -reactive protein levels (p=0.002) and CIMT (p<0.001) were significantly different. When we performed multivariate analyses to determine the independent predictors of CIMT and hair whitening, CIMT was found to be related to age, waist circumference, the levels of uric acid, bilirubin and gamma-glutamyl transpeptidase, the presence of a family history of CAD and hair whitening, while hair whitening was found to be related to age, hypertension, the bilirubin level and CIMT. Conclusion Our findings suggest that premature hair whitening intensity is independently related to CIMT. In cumulative assessments of CVRFs on the human body, the presence of premature hair whitening may be useful in identifying individuals with an increased risk of cardiovascular disease.

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Premature Hair Graying: A Probable Coronary Risk Factor

Cited by 36 publications

References 0 publications

Premature Hair Graying: Profiling the Scalp Anatomical Patterns of Occurrence in Tanzania

Premature Hair Graying: Profiling the Scalp Anatomical Patterns of Occurrence in Tanzania

The degree of premature hair graying as an independent risk marker for coronary artery disease: a predictor of biological age rather than chronological age

Premature Hair Whitening is an Independent Predictor of Carotid Intima-media Thickness in Young and Middle-aged Men

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