Premature Induction of Glucokinase in the Neonatal Rat by Thyroid Hormone

Partridge, Nicola C.; Hoh, C. H.; Weaver, P. K.; Oliver, I.T.

doi:10.1111/j.1432-1033.1975.tb03905.x

Cited by 43 publications

(21 citation statements)

References 17 publications

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“…A transient increase in the plasma thyroxine level between 12 and 20 days of age has been observed by Partridge et al (40). A similar pattern was observed in this study (table IV).…”

Section: Thyroxinesupporting

confidence: 79%

“…The second increase in creatine kinase activ ity (31) occurs simultaneously with a rise in plasma thyroxine levels (28,40). A transient increase in the plasma thyroxine level between 12 and 20 days of age has been observed by Partridge et al (40).…”

Section: Thyroxinementioning

confidence: 92%

“…thyroxine levels show that thiourea is very effective in suppressing the thyroid, when the treatment is started before the transient in crease of the plasma thyroxine level (40). Both body weight and enzyme activity are reduced especially at young ages, when the thyroxine levels of the control rats are high.…”

Section: Effect O F Glucocorticoid Antagonists and Inhibitors O F Thementioning

confidence: 93%

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Effect of Hormones on the Development of Creatine Kinase Activity in Rat Skeletal Muscle

Kloosterboer¹,

Faassen²,

Vries³

et al. 1979

Neonatology

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Various approaches have been used in order to determine whether or not a certain hormone is a stimulus for the development of the muscle-specific enzyme, creatine kinase. Both thyroxine and glucocorticoids can be considered as naturally occurring stimuli for the synthesis of creatine kinase. The maximum increase of creatine kinase activity after stimulation by glucocorticoids (about 25%) occurs between 5 and 7 days after birth. A single injection of thyroxine has virtually no effect during this period. However, when a pretreatment with thyroxine is given, cortisone acetate administration increases creatine kinase activity to about 155%. The effect of cortisone acetate is due to de novo synthesis of creatine kinase. The augmentation of the effect of cortisone acetate by thyroxine is dependent on DNA synthesis. Thyroxine administration apparently causes the formation of more competent muscle cells. The effects of both hormones are age-dependent. Thyroxine and cortisone acetate administration to fetuses can prematurely evoke the MM isoenzyme of creatine kinase. Both hormones probably play a role in the activation of the M gene during embryonic development. Sex hormones are able to influence neither creatine kinase activity nor muscle growth. However, castration of male rats immediately after birth causes an impairment of growth at older ages. The androgen production by the testes immediately after birth seems to be of main importance for body growth and development. It can be concluded from these results that creatine kinase in muscle is under multiple hormonal control, just as is observed for a number of enzymes in other tissues.

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“…A transient increase in the plasma thyroxine level between 12 and 20 days of age has been observed by Partridge et al (40). A similar pattern was observed in this study (table IV).…”

Section: Thyroxinesupporting

confidence: 79%

Section: Thyroxinementioning

confidence: 92%

Section: Effect O F Glucocorticoid Antagonists and Inhibitors O F Thementioning

confidence: 93%

See 1 more Smart Citation

Effect of Hormones on the Development of Creatine Kinase Activity in Rat Skeletal Muscle

Kloosterboer¹,

Faassen²,

Vries³

et al. 1979

Neonatology

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show abstract

“…Precocious appearance of the enzyme is induced by intubation of glucose; the resulting activities are enhanced by prior treatment of the animals with triiodothyronine (T3) [4,5]. The factors that regulate synthesis of glucokinase in neonatal rat liver are complex [6] and it would be advantageous to be able to study its synthesis in a liver preparation in isolation from extra-hepatic influences.…”

Section: Introductionmentioning

confidence: 99%

De novo synthesis of glucokinase in hepatocytes isolated from neonatal rats

Wakelam

Walker

1980

FEBS Letters

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“…The synthesis of many proteins by the liver is regulated by hormones and initiation of the expression of some proteins during development is dependent on hormone alterations (Greengard, 1970;Partridge et al, 1975). The interaction between endocrine events and the developmental maturity of the liver is important in determining exactly when a particular protein is first expressed (Scott and Yeoh, 1984).…”

mentioning

confidence: 99%