Premature Infants 750–1,250 g Birth Weight Supplemented with a Novel Human Milk-Derived Cream Are Discharged Sooner

Hair, Amy B.; Bergner, Erynn M.; Lee, Martin L.; Moreira, Alvaro; Hawthorne, Keli M.; Rechtman, David J.; Abrams, Steven A.; Blanco, Cynthia L.

doi:10.1089/bfm.2015.0166

Cited by 25 publications

(24 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Finally, the trend seen toward fewer ventilator days as a function of less cow's milk in the diet is consistent with the findings reported in a study 11 of a HM cream based supplement to the EHMD. This study showed significantly earlier discharge of extremely premature infants at lower corrected gestational ages with use of the cream supplement as opposed to the EHMD without it.…”

Section: Discussionsupporting

confidence: 88%

Beyond Necrotizing Enterocolitis: Other Clinical Advantages of an Exclusive Human Milk Diet

Hair

Rechtman²,

Lee

et al. 2018

Breastfeeding Medicine

Self Cite

View full text Add to dashboard Cite

Objective: Articles previously published by Sullivan et al. and Cristofalo et al. were reanalyzed using the proportion of cow milk-based nutrition received to determine whether that affected clinical outcomes during hospitalization for infants birth weight 500–1250 g. Abrams et al. showed in the same cohort incidences of necrotizing enterocolitis (NEC), NEC requiring surgery and sepsis increased proportionally to the amount of dietary cow milk.Methods: The data from the two studies conducted under essentially the same protocol were combined yielding a cohort of 260 infants receiving a diet ranging from 0% to 100% cow milk. Data analysis utilized negative binomial regression which mitigates differences between subjects in terms of their time on study by incorporating that number into the statistical model. The percent of cow milk-based nutrition was the only predictor investigated.Results: For all outcomes the larger the amount of cow's milk in the diet the greater the number of days of that intervention required. A trend toward statistical significance was seen for ventilator days; however, only parenteral nutrition (PN) days and days to full feeds achieved statistical significance.Conclusions: Incorporation of any cow milk-based nutrition into the diet of extremely premature infants correlates with more days on PN and a longer time to achieve full feeds. There was a nonstatistically significant trend toward increased ventilator days. These represent additional clinical consequences of the use of any cow milk-based protein in feeding EP infants.

show abstract

Section: Discussionsupporting

confidence: 88%

Beyond Necrotizing Enterocolitis: Other Clinical Advantages of an Exclusive Human Milk Diet

Hair

Rechtman²,

Lee

et al. 2018

Breastfeeding Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Various caloric densities of this fortifier allow for individual adjustment based on growth or blood urea nitrogen (BUN). More recently, a novel HM derived cream supplement has been produced by the same company (59, 60).…”

Section: Current Human Milk Fortifiers and Supplementsmentioning

confidence: 99%

Fortification of Human Milk for Preterm Infants: Update and Recommendations of the European Milk Bank Association (EMBA) Working Group on Human Milk Fortification

et al. 2019

View full text Add to dashboard Cite

Evidence indicates that human milk (HM) is the best form of nutrition uniquely suited not only to term but also to preterm infants conferring health benefits in both the short and long-term. However, HM does not provide sufficient nutrition for the very low birth weight (VLBW) infant when fed at the usual feeding volumes leading to slow growth with the risk of neurocognitive impairment and other poor health outcomes such as retinopathy and bronchopulmonary dysplasia. HM should be supplemented (fortified) with the nutrients in short supply, particularly with protein, calcium, and phosphate to meet the high requirements of this group of babies. In this paper the European Milk Bank Association (EMBA) Working Group on HM Fortification discusses the existing evidence in this field, gives an overview of different fortification approaches and definitions, outlines the gaps in knowledge and gives recommendations for practice and suggestions for future research. EMBA recognizes that “Standard Fortification,” which is currently the most utilized regimen in neonatal intensive care units, still falls short in supplying sufficient protein for some VLBW infants. EMBA encourages the use of “Individualized Fortification” to optimize nutrient intake. “Adjustable Fortification” and “Targeted Fortification” are 2 methods of individualized fortification. The quality and source of human milk fortifiers constitute another important topic. There is work looking at human milk derived fortifiers, but it is still too early to draw precise conclusions about their use. The pros and cons are discussed in this Commentary in addition to the evidence around use of fortifiers post discharge.

show abstract

“…More recently, human milk-based additives have been formulated and studies show the advantages of their use, such as improved morbidity and mortality rates, less incidence of NEC, decreased hospital stays, and improvement of infant growth and weight gain. Nevertheless, the cost of the product and the ethical questions related to its commercialization make it difficult to use it in neonatal intensive care units (ICUs) [26–29]. Thus, considering the recent scientific breakthroughs, the hypothesis of this study is that HM voluntarily donated to the HMB may be lyophilized, in a simple and effortless way, and used as an additive of HM to increase the levels of nutrients.…”

Section: Introductionmentioning

confidence: 99%

Development of a human milk concentrate with human milk lyophilizate for feeding very low birth weight preterm infants: A preclinical experimental study

et al. 2019

View full text Add to dashboard Cite

Breast milk is considered the gold standard nutritional resource for very low birth weight (VLBW) infants in terms of nutrients and protective factors. If mother's milk is not available, the second choice is donated and fortified human milk (HM) from the Human Milk Bank (HMB). This study hypothesized that HM could be lyophilized and used as an additive to increase the levels of macronutrients and micronutrients available to VLBW infants. This study aimed to constitute a lyophilized HM concentrate and determine the osmolality and the concentration of macronutrients and micronutrients in HM samples at “baseline” and in “HM concentrates”, analyzed immediately (HMCI), and after 3 (HMC3m) and 6 (HMC6m) months of freezing. Osmolality was verified using the freezing point osmometric method. Macronutrient quantification was performed using the MIRIS Human Milk Analyzer. Micronutrients were determined by Flame Atomic Absorption Spectrophotometry and by the automated colorimetric method. Bayesian linear mixed effect models were adjusted using OpenBUGS to estimate mean differences and 95% credibility intervals (CrI) of osmolality and of macro- and micronutrients between the types of HM samples. A comparison of dosage values showed a significant increase between HM baseline and HMCI, HMC3m, and HMC6m. Comparing HM baseline and HMCI highlighted the increase in energy content and the concentration of carbohydrates and total lipids. The Ca and P contents increased and the levels of energy, total lipids, and Cu were reduced in HMC3m compared to HMCI. Ca, Mg, K, Zn, and P increased and the levels of energy, total lipids, and Cu were reduced in HMC6m, compared to HMCI. The present study confirms the possibility of formulation and utilization of the immediate concentrate. Partial stability of HM concentrates generated from freeze-drying of donated milk do not recommend storage.

show abstract

Premature Infants 750–1,250 g Birth Weight Supplemented with a Novel Human Milk-Derived Cream Are Discharged Sooner

Cited by 25 publications

References 28 publications

Beyond Necrotizing Enterocolitis: Other Clinical Advantages of an Exclusive Human Milk Diet

Beyond Necrotizing Enterocolitis: Other Clinical Advantages of an Exclusive Human Milk Diet

Fortification of Human Milk for Preterm Infants: Update and Recommendations of the European Milk Bank Association (EMBA) Working Group on Human Milk Fortification

Development of a human milk concentrate with human milk lyophilizate for feeding very low birth weight preterm infants: A preclinical experimental study

Contact Info

Product

Resources

About