Premature myocardial infarction: Clinical profile and angiographic findings

Pineda, Javier; Marı́n, Francisco; Roldán, Vanessa; Valencia, José; Marco, Pascual; Sogorb, Francisco

doi:10.1016/j.ijcard.2007.02.038

Cited by 71 publications

(62 citation statements)

References 21 publications

(56 reference statements)

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“…Pineda et al [23] reported hypertension in 28.5% of patients aged ≤ 45 years and in 49.5% of patients aged > 45 years with MI. A similar dependency, but with a higher prevalence of hypertension in both age groups, was observed by Yunyun et al [24].…”

Section: Risk Factors For Myocardial Infarctionmentioning

confidence: 96%

“…Pineda et al [23] reported hyperlipidaemia in 73.6% of patients with premature MI. This condition was less prevalent in patients who experienced MI after the age of 45 years (59.5%).…”

Section: Risk Factors For Myocardial Infarctionmentioning

confidence: 97%

“…The prevalence of smoking among young individuals with MI ranges from 64.5% to 93.7%, depending on the study population [21][22][23][24][25].…”

Section: Risk Factors For Myocardial Infarctionmentioning

confidence: 99%

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Risk factors, prognosis, and secondary prevention of myocardial infarction in young adults in Poland

2016

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Section: Risk Factors For Myocardial Infarctionmentioning

confidence: 96%

“…Pineda et al [23] reported hyperlipidaemia in 73.6% of patients with premature MI. This condition was less prevalent in patients who experienced MI after the age of 45 years (59.5%).…”

Section: Risk Factors For Myocardial Infarctionmentioning

confidence: 97%

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Risk factors, prognosis, and secondary prevention of myocardial infarction in young adults in Poland

2016

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“…Forty‐five years as the upper limit of defining young adults has been used in various studies and appears to be a reasonable boundary 1, 2, 3, 4, 5, 6, 7, 8, 9, 10. The same age definition has been, therefore, used in the current study on clinical characteristics and outcomes of ACS in young adults.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, there is a paucity of studies on ACS in the young adults defined as previously described,1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and the records of these analyses are often dated. The most known of these studies is based on the Get With the Guidelines‐Coronary Artery Disease registry data 1.…”

Section: Introductionmentioning

confidence: 99%

Acute Coronary Syndrome: The Risk to Young Women

Ricci

Cenko

Vasiljević

et al. 2017

JAHA

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BackgroundAlthough acute coronary syndrome (ACS) mainly occurs in patients >50 years, younger patients can be affected as well. We used an age cutoff of 45 years to investigate clinical characteristics and outcomes of “young” patients with ACS.Methods and ResultsBetween October 2010 and April 2016, 14 931 patients with ACS were enrolled in the ISACS‐TC (International Survey of Acute Coronary Syndromes in Transitional Countries) registry. Of these patients, 1182 (8%) were aged ≤45 years (mean age, 40.3 years; 15.8% were women). The primary end point was 30‐day all‐cause mortality. Percentage diameter stenosis of ≤50% was defined as insignificant coronary disease. ST‐segment–elevation myocardial infarction was the most common clinical manifestation of ACS in the young cases (68% versus 59.6%). Young patients had a higher incidence of insignificant coronary artery disease (11.4% versus 10.1%) and lesser extent of significant disease (single vessel, 62.7% versus 46.6%). The incidence of 30‐day death was 1.3% versus 6.9% for the young and older patients, respectively. After correction for baseline and clinical differences, age ≤45 years was a predictor of survival in men (odds ratio, 0.24; 95% confidence interval, 0.10–0.58), but not in women (odds ratio, 1.35; 95% confidence interval, 0.50–3.62). This pattern of reversed risk among sexes held true after multivariable correction for in‐hospital medications and reperfusion therapy. Moreover, younger women had worse outcomes than men of a similar age (odds ratio, 6.03; 95% confidence interval, 2.07–17.53).Conclusion ACS at a young age is characterized by less severe coronary disease and high prevalence of ST‐segment–elevation myocardial infarction. Women have higher mortality than men. Young age is an independent predictor of lower 30‐day mortality in men, but not in women.Clinical Trial RegistrationURL: http://clinicaltrials.gov/. Unique identifier: NCT01218776.

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Acute ST‐elevation Myocardial Infarction in Young Patients: 15 Years of Experience in a Single Center

Chua¹,

Hung

Shyu

et al. 2010

Clinical Cardiology

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Background: There have been few studies done regarding young patients with ST-elevation myocardial infarction (STEMI). The purpose of this study was to investigate the clinical characteristics and coronary angiographic features in young patients with STEMI. Methods: We collected data on 849 consecutive patients with STEMI from 1992 to 2006. Baseline clinical characteristics, coronary anatomy, and outcome were compared in young (≤45 yrs) and older patients (>45 yrs). Results: Young patients presented 11.6% of all patients with STEMI. These patients were predominantly male (92.9% vs 80.3%, P < 0.001), more likely to smoke (75.8% vs 47.2%, P < 0.001), obese (48.2% vs 27.9%, P = 0.002), have higher triglyceride levels (176.9 ± 153.8 mg/dL vs 140.7 ± 112.7 mg/dL, P = 0.005), and lower high-density lipoprotein cholesterol (37.1 ± 7.9 mg/dL vs 42.8 ± 14.3 mg/dL, P = 0.005) than older patients. Also, younger patients had a shorter hospital stay (7.1 ± 4.9 d vs 8.5 ± 6.7 d, P = 0.04), less in-hospital morbidity (29.3% vs 39.7%, P = 0.02), and mortality (3.0% vs 12.3%, P = 0.002). Killip class III or IV could predict in-hospital morbidity and mortality in young patients. Both groups had similar rates of repeated percutaneous coronary intervention (PCI; 45.5% vs 41.5%, P = 0.23) and reinfarction (6.1% vs 3.2%, P = 0.32). Mortality rate during follow-up was significantly lower in younger patients (3.0% vs 19.6%, P < 0.001). Conclusion: Cigarette smoking, obesity, and dyslipidemia were the most important modifiable risk factors in young patients with STEMI. These patients had a better outcome than older patients without differences in repeated PCI and reinfarction between them. Only Killip class III or IV could predict in-hospital morbidity and mortality in young patients with STEMI.

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Premature myocardial infarction: Clinical profile and angiographic findings

Cited by 71 publications

References 21 publications

Risk factors, prognosis, and secondary prevention of myocardial infarction in young adults in Poland

Risk factors, prognosis, and secondary prevention of myocardial infarction in young adults in Poland

Acute Coronary Syndrome: The Risk to Young Women

Acute ST‐elevation Myocardial Infarction in Young Patients: 15 Years of Experience in a Single Center

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