Premature ovarian insufficiency: a syndrome or diagnosis

Татарчук, Т. Ф; Косей, Н. В.; Тутченко, Т. Н.

doi:10.18370/2309-4117.2017.34.16-22

Cited by 5 publications

(1 citation statement)

References 49 publications

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“…Despite the achievements of modern science, the mechanisms of stress-dependent hormonal implementation at the level of target organs are not sufficiently studied [11,12]. There is no evidence of chronic stress effect on premature ovarian insufficiency [13,14]. Original research…”

Section: ключові словаmentioning

confidence: 99%

Features of women’s reproductive dysfunctions associated with prolonged stressful situations

Horbatiuk

Shatkovska

Григоренко

et al. 2019

ZMJ

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The number of appeals of migrant women and servicewomen for specialized gynecological care has increased during the years of the armed conflict in Eastern Ukraine. The aim of the work was a comprehensive study of the hormonal function of pituitary gland, ovaries, thyroid gland and adrenal glands in women of reproductive age with various types of menstrual cycle disorders caused by a prolonged stressful situation. Materials and methods. With the help of immune-enzyme analysis the authors have conducted a study of pituitary hormones (FSH, LH, prolactin), ovarian hormones (estradiol, progesterone, free T), thyroid hormones (TSH, FТ 4) and thyroid peroxidase antibodies, as well as adrenal glands hormones (ACTH, cortisol (urine), DHEA-s) of 74 migrant women and servicewomen with menstrual disorders caused by a stressful situation. According to complaints, women were divided into 2 subgroups: with amenorrhea 34 (45.9 %) and abnormal uterine bleeding-40 (54.1 %). Results. Women with stressed amenorrhea had a significant 2 times (P < 0.05) increase in FSH; 1.9 times-LH; 1.6 timesprolactin (which is not typical for classical hyperprolactinemia) and 3.2 times decrease in estradiol, 3.9 times-progesterone in comparison to the control group. Dysfunction of the thyroid gland was recorded, in particular 2 times decrease in FT 4 and 1.7 times increase in thyroperoxidase antibodies relative to the control. A significant 1.6 times increase in ACTH, 1.8 times increase in cortisol (urine) and 1.6 times increase in DHEA-s were detected compared with the control. Women with abnormal uterine bleeding had a significant 1.5 times (P < 0.05) increase in prolactin, 1.3 times increase in estradiol, and a 2.5 times decrease in progesterone compared to the control women group. 90.5 % of women of reproductive age with menstrual cycle disorders caused by the influence of prolonged stress factor had hormonal disorders of the ovaries, adrenal glands and thyroid gland. Conclusions. In women with stress-related amenorrhea there is a violation of the relationship in the hypothalamic-pituitary system while maintaining the negative feedback loops of the pituitary-ovarian axis or ovarian depletion; post-traumatic stress disorders have a significant pathological effect on the reproductive system of women who have experienced such suffering.

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Section: ключові словаmentioning

confidence: 99%

Features of women’s reproductive dysfunctions associated with prolonged stressful situations

Horbatiuk

Shatkovska

Григоренко

et al. 2019

ZMJ

View full text Add to dashboard Cite

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Clinical manifestations of decreased ovarian reserve in premenopausal women: a cross-sectional study

Салимова

Danusevich

Nadeliaeva

et al. 2022

Ekologiya cheloveka (Human Ecology)

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The objective of the study was to estimate the prevalence and clinical manifestation of decreased ovarian reserve in women of reproductive age from Eastern Siberia Methods and Results: During a cross-sectional study, performed in 2017-2019 in Irkutsk Region and Buryat Republic (Russia), we invited 1119 women aged 18 to 40 yrs, who underwent an annual preventive medical examination at their place of work. Of 1119 women, 907 women aged 31,78 5,13 years were included in the study. We used clinical, instrumental, and laboratory research methods and statistical analysis. Of the 907 women included in the study, 117 participants 12.9% had a follicle number per ovary of less than 5 and were diagnosed as patients with decreased ovarian reserve (DOR). According to the laboratory study, 56 out of 117 (47.8%) AMH was below 1.2 ng/ml. The average value of which was 0.53 0.43 ng/ml. In women with reduced AMH levels, a shortening of the menstrual cycle and high parity were observed. Also, in 4 of 117 (3,4%) patients with a reduced number of antral follicles, premature ovarian failure was diagnosed. Conclusion: Determination of ovarian reserve by one AFC parameter may be useful for determining the risk group of women with premature ovarian insufficiency.

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Ceruloplasmin and complement C3 are markers of diminished ovarian reserve in premenopausal women

Салимова

Atalyan

Nadeliaeva

et al. 2023

Fundamentalʹnaâ i kliničeskaâ medicina

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Aim. To establish cut-off values for the concentrations of complement C3 and ceruloplasmin, diagnostic markers of reduced antral follicle count (AFC) and anti-Müllerian hormone (AMH) which both indicate diminished ovarian reserve, in women of reproductive age.Materials and Methods. Here we enrolled 864 women (18-40 years of age, average age 31.70 ± 5.14 years) who underwent an annual medical examination in 2017–2019 in the Irkutsk Region and the Republic of Buryatia. Reduced AFC was defined as ≤ 5 antral follicles in each ovary at pelvic ultrasound examination whilst reduced AMH was defined as < 1.2 ng/mL. In total, 112 women had reduced ovarian reserve and 752 were included into the control group. In addition to AMH, we also measured serum prolactin, gonadotropins, inhibin B, estradiol, complement C3, and ceruloplasmin using enzyme-linked immunosorbent assay. The cut-off values were determined by plotting a receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC).Results. The cut-off level of complement C3 was 894 (867; 1355.5) mg/mL [AUC: 0.769 (0.635; 0.904)] in women with reduced AFC (≤ 5) and 981.5 (916.5; 1467.5) mg/mL [AUC: 0.62 (0.493; 0.746)] in women with reduced AMH (< 1.2 ng/mL). The cut-off level of ceruloplasmin was 1.745 (1.625; 1.975) mg/mL [AUC: 0.859 (0.759; 0.96)] in women with reduced AFC (≤ 5) and 1.975 (1.665; 2.15) mg/mL, [AUC: 0.662 (0.542; 0.782)] in women with reduced AMH (< 1.2 ng/mL).Conclusion. We have established the cut-off values for the serum complement C3 and ceruloplasmin in women with reduced AFC and AMH, indicators defining diminished ovarian reserve in women of reproductive age.

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Premature ovarian insufficiency: a syndrome or diagnosis

Cited by 5 publications

References 49 publications

Features of women’s reproductive dysfunctions associated with prolonged stressful situations

Features of women’s reproductive dysfunctions associated with prolonged stressful situations

Clinical manifestations of decreased ovarian reserve in premenopausal women: a cross-sectional study

Ceruloplasmin and complement C3 are markers of diminished ovarian reserve in premenopausal women

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